HIT-result

Target Description

Type	Detail
Target ID	T86D6K
Protein Name	Polyunsaturated fatty acid lipoxygenase ALOX15
Uniprot ID	P16050
Protein Name Alias	12/15-lipoxygenase; Arachidonate 12-lipoxygenase, leukocyte-type; 12-LOX; EC 1.13.11.31; Arachidonate 15-lipoxygenase; 15-LOX; 15-LOX-1; EC 1.13.11.33; Arachidonate omega-6 lipoxygenase; Hepoxilin A3 synthase Alox15; EC 1.13.11.-; Linoleate 13S-lipoxygenase; EC 1.13.11.12
Gene ID	246
Gene Symbol	ALOX15
Gene Alias	LOG15
TTD	T16042: Patented target
Pfam	PF00305 ; PF01477
GO	0031234:extrinsic component of cytoplasmic side of plasma membrane 0006646:phosphatidylethanolamine biosynthetic process 0005811:lipid droplet 0016702:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 0016020:membrane 0004052:arachidonate 12(S)-lipoxygenase activity 0050727:regulation of inflammatory response 0010811:positive regulation of cell-substrate adhesion 0005829:cytosol 0047977:hepoxilin-epoxide hydrolase activity 0043651:linoleic acid metabolic process 0051122:hepoxilin biosynthetic process 0006629:lipid metabolic process 0006691:leukotriene metabolic process 0019372:lipoxygenase pathway 0016165:linoleate 13S-lipoxygenase activity 0005886:plasma membrane 0030282:bone mineralization 0043277:apoptotic cell clearance 0050473:arachidonate 15-lipoxygenase activity 0002820:negative regulation of adaptive immune response 0005506:iron ion binding 0034116:positive regulation of heterotypic cell-cell adhesion 2001303:lipoxin A4 biosynthetic process 1901074:regulation of engulfment of apoptotic cell 0034440:lipid oxidation 0019369:arachidonic acid metabolic process 0071277:cellular response to calcium ion 0019221:cytokine-mediated signaling pathway 0070374:positive regulation of ERK1 and ERK2 cascade 0001503:ossification 0042060:wound healing 0006954:inflammatory response 0042759:long-chain fatty acid biosynthetic process 0019395:fatty acid oxidation 0035358:regulation of peroxisome proliferator activated receptor signaling pathway 0034976:response to endoplasmic reticulum stress 0005546:phosphatidylinositol-4,5-bisphosphate binding 0035963:cellular response to interleukin-13 0051120:hepoxilin A3 synthase activity 0030838:positive regulation of actin filament polymerization
PDB	2ABT
Drugbank	DB02709 ; DB14011 ; DB14009 ; DB09061 ; DB08492
KEGG	hsa:246

Type

Detail

Target ID

T86D6K

Protein Name

Polyunsaturated fatty acid lipoxygenase ALOX15

Uniprot ID

P16050

Protein Name Alias

12/15-lipoxygenase; Arachidonate 12-lipoxygenase, leukocyte-type; 12-LOX; EC 1.13.11.31; Arachidonate 15-lipoxygenase; 15-LOX; 15-LOX-1; EC 1.13.11.33; Arachidonate omega-6 lipoxygenase; Hepoxilin A3 synthase Alox15; EC 1.13.11.-; Linoleate 13S-lipoxygenase; EC 1.13.11.12

Gene ID

246

Gene Symbol

ALOX15

Gene Alias

LOG15

TTD

T16042: Patented target

Pfam

PF00305 ; PF01477

0031234:extrinsic component of cytoplasmic side of plasma membrane

0006646:phosphatidylethanolamine biosynthetic process

0005811:lipid droplet

0016702:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

0016020:membrane

0004052:arachidonate 12(S)-lipoxygenase activity

0050727:regulation of inflammatory response

0010811:positive regulation of cell-substrate adhesion

0005829:cytosol

0047977:hepoxilin-epoxide hydrolase activity

0043651:linoleic acid metabolic process

0051122:hepoxilin biosynthetic process

0006629:lipid metabolic process

0006691:leukotriene metabolic process

0019372:lipoxygenase pathway

0016165:linoleate 13S-lipoxygenase activity

0005886:plasma membrane

0030282:bone mineralization

0043277:apoptotic cell clearance

0050473:arachidonate 15-lipoxygenase activity

0002820:negative regulation of adaptive immune response

0005506:iron ion binding

0034116:positive regulation of heterotypic cell-cell adhesion

2001303:lipoxin A4 biosynthetic process

1901074:regulation of engulfment of apoptotic cell

0034440:lipid oxidation

0019369:arachidonic acid metabolic process

0071277:cellular response to calcium ion

0019221:cytokine-mediated signaling pathway

0070374:positive regulation of ERK1 and ERK2 cascade

0001503:ossification

0042060:wound healing

0006954:inflammatory response

0042759:long-chain fatty acid biosynthetic process

0019395:fatty acid oxidation

0035358:regulation of peroxisome proliferator activated receptor signaling pathway

0034976:response to endoplasmic reticulum stress

0005546:phosphatidylinositol-4,5-bisphosphate binding

0035963:cellular response to interleukin-13

0051120:hepoxilin A3 synthase activity

0030838:positive regulation of actin filament polymerization

PDB

2ABT

Drugbank

DB02709 ; DB14011 ; DB14009 ; DB09061 ; DB08492

KEGG

hsa:246

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0530	Tao Ren Shuang	桃仁霜	Peach kernel	Prunus persica
H1225	Huai Mi	槐米	NA	Sophora japonica
H1016	Du Zhong Tan	杜仲炭	Eucommia	Eucommia ulmoides
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H0155	Ban Xia	半夏	Ternate pinellia	Pinellia ternata
H1015	Du Zhong	杜仲	Eucommia	Eucommia ulmoides
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H1254	Huang Qin Tan	黄芩炭	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0529	Tao Ren	桃仁	Peach kernel	Prunus persica
H1017	Du Zhong Ye	杜仲叶	Eucommia leaf	Eucommia ulmoides
H0605	Wu Wei Zi	五味子	Chinese magnoliavine	Schisandra chinensis
H0429	Shao Yao	芍药	Red peony root	Paeonia obovata
H0784	Chi Shao	赤芍	Red peony root	Paeonia obovata
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H0531	Tao Zhi	桃枝	Peach juvenile branch	Prunus persica
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H1251	Huang Qin	黄芩	Root of Baikal skullcaap	Scutellaria baicalensis
H1253	Huang Qin Jin Gao Fen	黄芩浸膏粉	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0310	Pian Qin	片芩	Scutellaria amoena	Scutellaria baicalensis
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H0527	Tao	桃	Peach	Prunus persica
H0164	Ban Zhi Lian	半枝莲	Barbed skullcap	Scutellaria barbata
H1252	Huang Qin Jin Gao	黄芩浸膏	Extract of root of Baikal skullcaap	Scutellaria baicalensis

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 28)