Target Description

Type Detail
Target ID T87C5Q
Protein Name Polyunsaturated fatty acid lipoxygenase ALOX12
Uniprot ID P18054
Protein Name Alias EC 1.13.11.-;  Arachidonate (12S)-lipoxygenase;  12S-LOX;  12S-lipoxygenase;  EC 1.13.11.31;  Arachidonate (15S)-lipoxygenase;  EC 1.13.11.33;  Linoleate (13S)-lipoxygenase;  Lipoxin synthase 12-LO;  EC 3.3.2.-;  Platelet-type lipoxygenase 12
Gene ID 239
Gene Symbol ALOX12
Gene Alias 12LO;  LOG12
TTD T35527: Research target
Pfam PF00305 ; PF01477
GO
0019395:fatty acid oxidation

0006629:lipid metabolic process

0004052:arachidonate 12(S)-lipoxygenase activity

0051122:hepoxilin biosynthetic process

0005829:cytosol

0061436:establishment of skin barrier

1905956:positive regulation of endothelial tube morphogenesis

0048661:positive regulation of smooth muscle cell proliferation

0043536:positive regulation of blood vessel endothelial cell migration

0016165:linoleate 13S-lipoxygenase activity

0016020:membrane

0034440:lipid oxidation

0005506:iron ion binding

0042383:sarcolemma

0090331:negative regulation of platelet aggregation

0010628:positive regulation of gene expression

0033559:unsaturated fatty acid metabolic process

0019372:lipoxygenase pathway

0019369:arachidonic acid metabolic process

0047977:hepoxilin-epoxide hydrolase activity

1901751:leukotriene A4 metabolic process

0070062:extracellular exosome

2001303:lipoxin A4 biosynthetic process

0042554:superoxide anion generation

0043651:linoleic acid metabolic process

0050473:arachidonate 15-lipoxygenase activity

0043065:positive regulation of apoptotic process

0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

0010656:negative regulation of muscle cell apoptotic process

0016702:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

0005886:plasma membrane

2001306:lipoxin B4 biosynthetic process

0042759:long-chain fatty acid biosynthetic process

0051901:positive regulation of mitochondrial depolarization

2001301:lipoxin biosynthetic process

0007568:aging

0071396:cellular response to lipid

0005737:cytoplasm

0051121:hepoxilin metabolic process

PDB 3D3L ; 2ABU
Drugbank NA
KEGG hsa:239

Related Compounds  (Total: 3)

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C0713
Name: Baicalein
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C1114
Name: Baicalein
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C1228
Name: Chenodiol


Related Herbs  (Total: 27)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H1225 Huai Mi槐米 NASophora japonica
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H1227 Huai Zhi槐枝 NASophora japonica
H0155 Ban Xia半夏 Ternate pinelliaPinellia ternata
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H0429 Shao Yao芍药 Red peony rootPaeonia obovata
H0784 Chi Shao赤芍 Red peony rootPaeonia obovata
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H0527 Tao PeachPrunus persica
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis