HIT-result

Target Description

Type	Detail
Target ID	T71KM2
Protein Name	TGF-beta receptor type-1
Uniprot ID	P36897
Protein Name Alias	TGFR-1; EC 2.7.11.30; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I
Gene ID	7046
Gene Symbol	TGFBR1
Gene Alias	ALK5; SKR4
TTD	T53389: Clinical Trial target
Pfam	PF00069 ; PF08515 ; PF01064
GO	0010862:positive regulation of pathway-restricted SMAD protein phosphorylation 0005923:bicellular tight junction 0009986:cell surface 0060043:regulation of cardiac muscle cell proliferation 0048663:neuron fate commitment 0016579:protein deubiquitination 0060017:parathyroid gland development 0009952:anterior/posterior pattern specification 2001237:negative regulation of extrinsic apoptotic signaling pathway 0032924:activin receptor signaling pathway 0048538:thymus development 0000186:activation of MAPKK activity 0043542:endothelial cell migration 0010718:positive regulation of epithelial to mesenchymal transition 0071363:cellular response to growth factor stimulus 0060412:ventricular septum morphogenesis 0008584:male gonad development 0007179:transforming growth factor beta receptor signaling pathway 0042060:wound healing 0060982:coronary artery morphogenesis 0050431:transforming growth factor beta binding 0006355:regulation of transcription, DNA-templated 0004674:protein serine/threonine kinase activity 0007399:nervous system development 0035556:intracellular signal transduction 0005024:transforming growth factor beta-activated receptor activity 0005524:ATP binding 0018107:peptidyl-threonine phosphorylation 0001837:epithelial to mesenchymal transition 0048185:activin binding 1905007:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation 0043062:extracellular structure organization 0046872:metal ion binding 0048179:activin receptor complex 0006915:apoptotic process 0060037:pharyngeal system development 0001822:kidney development 0002088:lens development in camera-type eye 0001937:negative regulation of endothelial cell proliferation 0060391:positive regulation of SMAD protein signal transduction 0004672:protein kinase activity 1905075:positive regulation of tight junction disassembly 0008284:positive regulation of cell population proliferation 0048844:artery morphogenesis 0071560:cellular response to transforming growth factor beta stimulus 0051897:positive regulation of protein kinase B signaling 0051272:positive regulation of cellular component movement 0003223:ventricular compact myocardium morphogenesis 0048705:skeletal system morphogenesis 0051491:positive regulation of filopodium assembly 0048701:embryonic cranial skeleton morphogenesis 0005025:transforming growth factor beta receptor activity, type I 0016020:membrane 0030199:collagen fibril organization 0007507:heart development 0032331:negative regulation of chondrocyte differentiation 0010468:regulation of gene expression 0007050:cell cycle arrest 0051496:positive regulation of stress fiber assembly 0030307:positive regulation of cell growth 0060317:cardiac epithelial to mesenchymal transition 0016361:activin receptor activity, type I 0060021:roof of mouth development 0005886:plasma membrane 0005768:endosome 0008354:germ cell migration 0048762:mesenchymal cell differentiation 0010717:regulation of epithelial to mesenchymal transition 0005634:nucleus 0060978:angiogenesis involved in coronary vascular morphogenesis 2001235:positive regulation of apoptotic signaling pathway 0010628:positive regulation of gene expression 1905223:epicardium morphogenesis 0007165:signal transduction 0031396:regulation of protein ubiquitination 0060389:pathway-restricted SMAD protein phosphorylation 0046332:SMAD binding 0006468:protein phosphorylation 0001938:positive regulation of endothelial cell proliferation 0001824:blastocyst development 0009791:post-embryonic development 0018105:peptidyl-serine phosphorylation 0030512:negative regulation of transforming growth factor beta receptor signaling pathway 0042118:endothelial cell activation 0001501:skeletal system development 0003222:ventricular trabecula myocardium morphogenesis 0001701:in utero embryonic development 0045893:positive regulation of transcription, DNA-templated 0030335:positive regulation of cell migration 0043235:receptor complex 0043393:regulation of protein binding 0005114:type II transforming growth factor beta receptor binding 0045121:membrane raft 0070723:response to cholesterol 0070411:I-SMAD binding 0048870:cell motility
PDB	1TBI ; 3KFD ; 5E8W ; 5E8X ; 4X2J ; 3HMM ; 5E8Z ; 2X7O ; 5QIL ; 1IAS ; 4X0M ; 3TZM ; 5QTZ ; 5FRI ; 1PY5 ; 1VJY ; 5E90 ; 1B6C ; 5E8S ; 5QU0 ; 2PJY ; 6B8Y ; 5QIM ; 2L5S ; 3KCF ; 5E8T ; 4X2F ; 1RW8 ; 3FAA ; 5USQ ; 4X2N ; 4X2K ; 5E8U ; 4X2G ; 2WOU ; 6MAC ; 2WOT ; 3GXL ; 5QIK
Drugbank	DB03921 ; DB07152 ; DB08450 ; DB04434 ; DB04480 ; DB12010 ; DB07267
KEGG	hsa:7046

Type

Detail

Target ID

T71KM2

Protein Name

TGF-beta receptor type-1

Uniprot ID

P36897

Protein Name Alias

TGFR-1; EC 2.7.11.30; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I

Gene ID

7046

Gene Symbol

TGFBR1

Gene Alias

ALK5; SKR4

TTD

T53389: Clinical Trial target

Pfam

PF00069 ; PF08515 ; PF01064

0010862:positive regulation of pathway-restricted SMAD protein phosphorylation

0005923:bicellular tight junction

0009986:cell surface

0060043:regulation of cardiac muscle cell proliferation

0048663:neuron fate commitment

0016579:protein deubiquitination

0060017:parathyroid gland development

0009952:anterior/posterior pattern specification

2001237:negative regulation of extrinsic apoptotic signaling pathway

0032924:activin receptor signaling pathway

0048538:thymus development

0000186:activation of MAPKK activity

0043542:endothelial cell migration

0010718:positive regulation of epithelial to mesenchymal transition

0071363:cellular response to growth factor stimulus

0060412:ventricular septum morphogenesis

0008584:male gonad development

0007179:transforming growth factor beta receptor signaling pathway

0042060:wound healing

0060982:coronary artery morphogenesis

0050431:transforming growth factor beta binding

0006355:regulation of transcription, DNA-templated

0004674:protein serine/threonine kinase activity

0007399:nervous system development

0035556:intracellular signal transduction

0005024:transforming growth factor beta-activated receptor activity

0005524:ATP binding

0018107:peptidyl-threonine phosphorylation

0001837:epithelial to mesenchymal transition

0048185:activin binding

1905007:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

0043062:extracellular structure organization

0046872:metal ion binding

0048179:activin receptor complex

0006915:apoptotic process

0060037:pharyngeal system development

0001822:kidney development

0002088:lens development in camera-type eye

0001937:negative regulation of endothelial cell proliferation

0060391:positive regulation of SMAD protein signal transduction

0004672:protein kinase activity

1905075:positive regulation of tight junction disassembly

0008284:positive regulation of cell population proliferation

0048844:artery morphogenesis

0071560:cellular response to transforming growth factor beta stimulus

0051897:positive regulation of protein kinase B signaling

0051272:positive regulation of cellular component movement

0003223:ventricular compact myocardium morphogenesis

0048705:skeletal system morphogenesis

0051491:positive regulation of filopodium assembly

0048701:embryonic cranial skeleton morphogenesis

0005025:transforming growth factor beta receptor activity, type I

0016020:membrane

0030199:collagen fibril organization

0007507:heart development

0032331:negative regulation of chondrocyte differentiation

0010468:regulation of gene expression

0007050:cell cycle arrest

0051496:positive regulation of stress fiber assembly

0030307:positive regulation of cell growth

0060317:cardiac epithelial to mesenchymal transition

0016361:activin receptor activity, type I

0060021:roof of mouth development

0005886:plasma membrane

0005768:endosome

0008354:germ cell migration

0048762:mesenchymal cell differentiation

0010717:regulation of epithelial to mesenchymal transition

0005634:nucleus

0060978:angiogenesis involved in coronary vascular morphogenesis

2001235:positive regulation of apoptotic signaling pathway

0010628:positive regulation of gene expression

1905223:epicardium morphogenesis

0007165:signal transduction

0031396:regulation of protein ubiquitination

0060389:pathway-restricted SMAD protein phosphorylation

0046332:SMAD binding

0006468:protein phosphorylation

0001938:positive regulation of endothelial cell proliferation

0001824:blastocyst development

0009791:post-embryonic development

0018105:peptidyl-serine phosphorylation

0030512:negative regulation of transforming growth factor beta receptor signaling pathway

0042118:endothelial cell activation

0001501:skeletal system development

0003222:ventricular trabecula myocardium morphogenesis

0001701:in utero embryonic development

0045893:positive regulation of transcription, DNA-templated

0030335:positive regulation of cell migration

0043235:receptor complex

0043393:regulation of protein binding

0005114:type II transforming growth factor beta receptor binding

0045121:membrane raft

0070723:response to cholesterol

0070411:I-SMAD binding

0048870:cell motility

PDB

1TBI ; 3KFD ; 5E8W ; 5E8X ; 4X2J ; 3HMM ; 5E8Z ; 2X7O ; 5QIL ; 1IAS ; 4X0M ; 3TZM ; 5QTZ ; 5FRI ; 1PY5 ; 1VJY ; 5E90 ; 1B6C ; 5E8S ; 5QU0 ; 2PJY ; 6B8Y ; 5QIM ; 2L5S ; 3KCF ; 5E8T ; 4X2F ; 1RW8 ; 3FAA ; 5USQ ; 4X2N ; 4X2K ; 5E8U ; 4X2G ; 2WOU ; 6MAC ; 2WOT ; 3GXL ; 5QIK

Drugbank

DB03921 ; DB07152 ; DB08450 ; DB04434 ; DB04480 ; DB12010 ; DB07267

KEGG

hsa:7046

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0527	Tao	桃	Peach	Prunus persica
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0784	Chi Shao	赤芍	Red peony root	Paeonia obovata
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H1251	Huang Qin	黄芩	Root of Baikal skullcaap	Scutellaria baicalensis
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0531	Tao Zhi	桃枝	Peach juvenile branch	Prunus persica
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0310	Pian Qin	片芩	Scutellaria amoena	Scutellaria baicalensis
H1253	Huang Qin Jin Gao Fen	黄芩浸膏粉	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0429	Shao Yao	芍药	Red peony root	Paeonia obovata
H0529	Tao Ren	桃仁	Peach kernel	Prunus persica
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H1252	Huang Qin Jin Gao	黄芩浸膏	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H1225	Huai Mi	槐米	NA	Sophora japonica
H1254	Huang Qin Tan	黄芩炭	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H1015	Du Zhong	杜仲	Eucommia	Eucommia ulmoides
H1017	Du Zhong Ye	杜仲叶	Eucommia leaf	Eucommia ulmoides
H1016	Du Zhong Tan	杜仲炭	Eucommia	Eucommia ulmoides
H0530	Tao Ren Shuang	桃仁霜	Peach kernel	Prunus persica
H0164	Ban Zhi Lian	半枝莲	Barbed skullcap	Scutellaria barbata

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 31)