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Target Description

Type Detail
Target ID T71KM2
Protein Name TGF-beta receptor type-1
Uniprot ID P36897
Protein Name Alias TGFR-1;  EC 2.7.11.30;  Activin A receptor type II-like protein kinase of 53kD;  Activin receptor-like kinase 5;  ALK-5;  ALK5;  Serine/threonine-protein kinase receptor R4;  SKR4;  TGF-beta type I receptor;  Transforming growth factor-beta receptor type I;  TGF-beta receptor type I;  TbetaR-I
Gene ID 7046
Gene Symbol TGFBR1
Gene Alias ALK5;  SKR4
TTD T53389: Clinical Trial target
Pfam PF00069 ; PF08515 ; PF01064
GO
0010862:positive regulation of pathway-restricted SMAD protein phosphorylation

0005923:bicellular tight junction

0009986:cell surface

0060043:regulation of cardiac muscle cell proliferation

0048663:neuron fate commitment

0016579:protein deubiquitination

0060017:parathyroid gland development

0009952:anterior/posterior pattern specification

2001237:negative regulation of extrinsic apoptotic signaling pathway

0032924:activin receptor signaling pathway

0048538:thymus development

0000186:activation of MAPKK activity

0043542:endothelial cell migration

0010718:positive regulation of epithelial to mesenchymal transition

0071363:cellular response to growth factor stimulus

0060412:ventricular septum morphogenesis

0008584:male gonad development

0007179:transforming growth factor beta receptor signaling pathway

0042060:wound healing

0060982:coronary artery morphogenesis

0050431:transforming growth factor beta binding

0006355:regulation of transcription, DNA-templated

0004674:protein serine/threonine kinase activity

0007399:nervous system development

0035556:intracellular signal transduction

0005024:transforming growth factor beta-activated receptor activity

0005524:ATP binding

0018107:peptidyl-threonine phosphorylation

0001837:epithelial to mesenchymal transition

0048185:activin binding

1905007:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

0043062:extracellular structure organization

0046872:metal ion binding

0048179:activin receptor complex

0006915:apoptotic process

0060037:pharyngeal system development

0001822:kidney development

0002088:lens development in camera-type eye

0001937:negative regulation of endothelial cell proliferation

0060391:positive regulation of SMAD protein signal transduction

0004672:protein kinase activity

1905075:positive regulation of tight junction disassembly

0008284:positive regulation of cell population proliferation

0048844:artery morphogenesis

0071560:cellular response to transforming growth factor beta stimulus

0051897:positive regulation of protein kinase B signaling

0051272:positive regulation of cellular component movement

0003223:ventricular compact myocardium morphogenesis

0048705:skeletal system morphogenesis

0051491:positive regulation of filopodium assembly

0048701:embryonic cranial skeleton morphogenesis

0005025:transforming growth factor beta receptor activity, type I

0016020:membrane

0030199:collagen fibril organization

0007507:heart development

0032331:negative regulation of chondrocyte differentiation

0010468:regulation of gene expression

0007050:cell cycle arrest

0051496:positive regulation of stress fiber assembly

0030307:positive regulation of cell growth

0060317:cardiac epithelial to mesenchymal transition

0016361:activin receptor activity, type I

0060021:roof of mouth development

0005886:plasma membrane

0005768:endosome

0008354:germ cell migration

0048762:mesenchymal cell differentiation

0010717:regulation of epithelial to mesenchymal transition

0005634:nucleus

0060978:angiogenesis involved in coronary vascular morphogenesis

2001235:positive regulation of apoptotic signaling pathway

0010628:positive regulation of gene expression

1905223:epicardium morphogenesis

0007165:signal transduction

0031396:regulation of protein ubiquitination

0060389:pathway-restricted SMAD protein phosphorylation

0046332:SMAD binding

0006468:protein phosphorylation

0001938:positive regulation of endothelial cell proliferation

0001824:blastocyst development

0009791:post-embryonic development

0018105:peptidyl-serine phosphorylation

0030512:negative regulation of transforming growth factor beta receptor signaling pathway

0042118:endothelial cell activation

0001501:skeletal system development

0003222:ventricular trabecula myocardium morphogenesis

0001701:in utero embryonic development

0045893:positive regulation of transcription, DNA-templated

0030335:positive regulation of cell migration

0043235:receptor complex

0043393:regulation of protein binding

0005114:type II transforming growth factor beta receptor binding

0045121:membrane raft

0070723:response to cholesterol

0070411:I-SMAD binding

0048870:cell motility
PDB 1TBI ; 3KFD ; 5E8W ; 5E8X ; 4X2J ; 3HMM ; 5E8Z ; 2X7O ; 5QIL ; 1IAS ; 4X0M ; 3TZM ; 5QTZ ; 5FRI ; 1PY5 ; 1VJY ; 5E90 ; 1B6C ; 5E8S ; 5QU0 ; 2PJY ; 6B8Y ; 5QIM ; 2L5S ; 3KCF ; 5E8T ; 4X2F ; 1RW8 ; 3FAA ; 5USQ ; 4X2N ; 4X2K ; 5E8U ; 4X2G ; 2WOU ; 6MAC ; 2WOT ; 3GXL ; 5QIK
Drugbank DB03921 ; DB07152 ; DB08450 ; DB04434 ; DB04480 ; DB12010 ; DB07267
KEGG hsa:7046

Related Compounds  (Total: 2)

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C0739
Name: (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione
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C1114
Name: Baicalein


Related Herbs  (Total: 31)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H1225 Huai Mi槐米 NASophora japonica
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0472 Shu Da Huang熟大黄 NARheum palmatum
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H0527 Tao桃 PeachPrunus persica
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H0784 Chi Shao赤芍 Red peony rootPaeonia obovata
H1227 Huai Zhi槐枝 NASophora japonica
H0429 Shao Yao芍药 Red peony rootPaeonia obovata
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale


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