HIT-result

Target Description

Type	Detail
Target ID	T06URY
Protein Name	Transcription factor Sp1
Uniprot ID	P08047
Protein Name Alias	NA
Gene ID	6667
Gene Symbol	SP1
Gene Alias	TSFP1
TTD	T61544: Clinical Trial target
Pfam	PF00096
GO	0005634:nucleus 0043923:positive regulation by host of viral transcription 0045766:positive regulation of angiogenesis 0046872:metal ion binding 0070491:repressing transcription factor binding 0001103:RNA polymerase II repressing transcription factor binding 1902004:positive regulation of amyloid-beta formation 0042826:histone deacetylase binding 0071837:HMG box domain binding 0043536:positive regulation of blood vessel endothelial cell migration 0008022:protein C-terminus binding 0003700:DNA-binding transcription factor activity 0043425:bHLH transcription factor binding 0003690:double-stranded DNA binding 0001228:DNA-binding transcription activator activity, RNA polymerase II-specific 1990837:sequence-specific double-stranded DNA binding 0042803:protein homodimerization activity 0000976:transcription regulatory region sequence-specific DNA binding 0019216:regulation of lipid metabolic process 0010628:positive regulation of gene expression 0032993:protein-DNA complex 0000791:euchromatin 0005654:nucleoplasm 0017053:transcription repressor complex 0045893:positive regulation of transcription, DNA-templated 0045944:positive regulation of transcription by RNA polymerase II 0000987:cis-regulatory region sequence-specific DNA binding 0042795:snRNA transcription by RNA polymerase II 0035035:histone acetyltransferase binding 0006357:regulation of transcription by RNA polymerase II 0033194:response to hydroperoxide 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0000977:RNA polymerase II transcription regulatory region sequence-specific DNA binding 0008134:transcription factor binding 1905564:positive regulation of vascular endothelial cell proliferation 1904828:positive regulation of hydrogen sulfide biosynthetic process 0043565:sequence-specific DNA binding 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0048511:rhythmic process 0003677:DNA binding 0032869:cellular response to insulin stimulus 0005737:cytoplasm 0006355:regulation of transcription, DNA-templated 0000785:chromatin 0016032:viral process
PDB	1SP2 ; 1VA3 ; 6PV2 ; 6PV3 ; 6UCO ; 1VA2 ; 1SP1 ; 6PV0 ; 6UCP ; 6PV1 ; 1VA1
Drugbank	NA
KEGG	hsa:6667

Type

Detail

Target ID

T06URY

Protein Name

Transcription factor Sp1

Uniprot ID

P08047

Protein Name Alias

Gene ID

6667

Gene Symbol

SP1

Gene Alias

TSFP1

TTD

T61544: Clinical Trial target

Pfam

PF00096

0005634:nucleus

0043923:positive regulation by host of viral transcription

0045766:positive regulation of angiogenesis

0046872:metal ion binding

0070491:repressing transcription factor binding

0001103:RNA polymerase II repressing transcription factor binding

1902004:positive regulation of amyloid-beta formation

0042826:histone deacetylase binding

0071837:HMG box domain binding

0043536:positive regulation of blood vessel endothelial cell migration

0008022:protein C-terminus binding

0003700:DNA-binding transcription factor activity

0043425:bHLH transcription factor binding

0003690:double-stranded DNA binding

0001228:DNA-binding transcription activator activity, RNA polymerase II-specific

1990837:sequence-specific double-stranded DNA binding

0042803:protein homodimerization activity

0000976:transcription regulatory region sequence-specific DNA binding

0019216:regulation of lipid metabolic process

0010628:positive regulation of gene expression

0032993:protein-DNA complex

0000791:euchromatin

0005654:nucleoplasm

0017053:transcription repressor complex

0045893:positive regulation of transcription, DNA-templated

0045944:positive regulation of transcription by RNA polymerase II

0000987:cis-regulatory region sequence-specific DNA binding

0042795:snRNA transcription by RNA polymerase II

0035035:histone acetyltransferase binding

0006357:regulation of transcription by RNA polymerase II

0033194:response to hydroperoxide

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0000977:RNA polymerase II transcription regulatory region sequence-specific DNA binding

0008134:transcription factor binding

1905564:positive regulation of vascular endothelial cell proliferation

1904828:positive regulation of hydrogen sulfide biosynthetic process

0043565:sequence-specific DNA binding

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0048511:rhythmic process

0003677:DNA binding

0032869:cellular response to insulin stimulus

0005737:cytoplasm

0006355:regulation of transcription, DNA-templated

0000785:chromatin

0016032:viral process

PDB

1SP2 ; 1VA3 ; 6PV2 ; 6PV3 ; 6UCO ; 1VA2 ; 1SP1 ; 6PV0 ; 6UCP ; 6PV1 ; 1VA1

Drugbank

KEGG

hsa:6667

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0189	Lv Cha	绿茶	Green tea	Folium camelliae sinensis
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H1029	Fang Er Cha	方儿茶	khair in hindi	Senegalia catechu
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0819	Zhi Zi Jin Gao	栀子浸膏	Cape jasmine fruit	Gardenia jasminoides
H0424	Shan Zhi	山栀	Cape jasmine	Gardenia jasminoides
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0692	Xue Ren Shen	血人参	NA	Lespedeza bicolor
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H1004	Bai Cha	白茶	White tea	Camellia sinensis
H0818	Zhi Zi	栀子	Cape jasmine fruit	Gardenia jasminoides
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0637	Cha Ye	茶叶	Common tea	Camellia sinensis
H1034	Fei Yang Cao	飞杨草	NA	Euphorbia hirta
H0721	Yang Mei Gen	杨梅根	Myrica rubra sieb. et zucc	Myrica rubra
H0166	Long Kui	龙葵	Black nightshade	Solanum nigrum

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 24)