Target Description

Type Detail
Target ID T28HCY
Protein Name Presenilin-1
Uniprot ID P49768
Protein Name Alias PS-1;  EC 3.4.23.-;  Protein S182
Gene ID 5663
Gene Symbol PSEN1
Gene Alias AD3;  PS1;  PSNL1
TTD T93105: Clinical Trial target
Pfam PF01080
GO
0021904:dorsal/ventral neural tube patterning

0016235:aggresome

0002286:T cell activation involved in immune response

0035556:intracellular signal transduction

0010975:regulation of neuron projection development

0048143:astrocyte activation

0006816:calcium ion transport

0006509:membrane protein ectodomain proteolysis

0070765:gamma-secretase complex

0005790:smooth endoplasmic reticulum

0010468:regulation of gene expression

0048538:thymus development

0002265:astrocyte activation involved in immune response

0007611:learning or memory

0001921:positive regulation of receptor recycling

0060828:regulation of canonical Wnt signaling pathway

0005783:endoplasmic reticulum

0030018:Z disc

0050808:synapse organization

0032092:positive regulation of protein binding

0016021:integral component of membrane

0051208:sequestering of calcium ion

0010629:negative regulation of gene expression

0008021:synaptic vesicle

0003407:neural retina development

0006979:response to oxidative stress

1904646:cellular response to amyloid-beta

0043085:positive regulation of catalytic activity

0098712:L-glutamate import across plasma membrane

0000045:autophagosome assembly

1990535:neuron projection maintenance

0032469:endoplasmic reticulum calcium ion homeostasis

0043198:dendritic shaft

0007613:memory

0004175:endopeptidase activity

0070851:growth factor receptor binding

0043066:negative regulation of apoptotic process

0048167:regulation of synaptic plasticity

0005813:centrosome

0051117:ATPase binding

1904797:negative regulation of core promoter binding

0016324:apical plasma membrane

0035333:Notch receptor processing, ligand-dependent

0005262:calcium channel activity

0000139:Golgi membrane

0042307:positive regulation of protein import into nucleus

0042982:amyloid precursor protein metabolic process

0005887:integral component of plasma membrane

0043005:neuron projection

0010628:positive regulation of gene expression

0048471:perinuclear region of cytoplasm

0042987:amyloid precursor protein catabolic process

0045821:positive regulation of glycolytic process

0045121:membrane raft

0050435:amyloid-beta metabolic process

0031901:early endosome membrane

0048854:brain morphogenesis

0051402:neuron apoptotic process

0035253:ciliary rootlet

0043406:positive regulation of MAP kinase activity

0032760:positive regulation of tumor necrosis factor production

0005739:mitochondrion

0030165:PDZ domain binding

0005743:mitochondrial inner membrane

0005791:rough endoplasmic reticulum

0032436:positive regulation of proteasomal ubiquitin-dependent protein catabolic process

0001568:blood vessel development

0051966:regulation of synaptic transmission, glutamatergic

0030426:growth cone

0006839:mitochondrial transport

0005634:nucleus

0048666:neuron development

1905908:positive regulation of amyloid fibril formation

0034205:amyloid-beta formation

0001756:somitogenesis

0043524:negative regulation of neuron apoptotic process

0042325:regulation of phosphorylation

0030326:embryonic limb morphogenesis

0009791:post-embryonic development

0042327:positive regulation of phosphorylation

0005938:cell cortex

0051444:negative regulation of ubiquitin-protein transferase activity

0060075:regulation of resting membrane potential

0009986:cell surface

0007220:Notch receptor processing

0021795:cerebral cortex cell migration

0005640:nuclear outer membrane

0006486:protein glycosylation

0048013:ephrin receptor signaling pathway

0051563:smooth endoplasmic reticulum calcium ion homeostasis

0031965:nuclear membrane

0043312:neutrophil degranulation

0002038:positive regulation of L-glutamate import across plasma membrane

0016020:membrane

0000776:kinetochore

0099056:integral component of presynaptic membrane

0045893:positive regulation of transcription, DNA-templated

0000122:negative regulation of transcription by RNA polymerase II

0042383:sarcolemma

0098609:cell-cell adhesion

0004190:aspartic-type endopeptidase activity

0031293:membrane protein intracellular domain proteolysis

0050673:epithelial cell proliferation

0002244:hematopoietic progenitor cell differentiation

0001708:cell fate specification

0021870:Cajal-Retzius cell differentiation

0008013:beta-catenin binding

0043589:skin morphogenesis

0015871:choline transport

0005789:endoplasmic reticulum membrane

0001764:neuron migration

0021549:cerebellum development

0001947:heart looping

0043011:myeloid dendritic cell differentiation

0005765:lysosomal membrane

0042500:aspartic endopeptidase activity, intramembrane cleaving

0050852:T cell receptor signaling pathway

0090647:modulation of age-related behavioral decline

2001234:negative regulation of apoptotic signaling pathway

0035577:azurophil granule membrane

0005886:plasma membrane

0007175:negative regulation of epidermal growth factor-activated receptor activity

0050820:positive regulation of coagulation

0048705:skeletal system morphogenesis

0060999:positive regulation of dendritic spine development

0015031:protein transport

0016080:synaptic vesicle targeting

0032991:protein-containing complex

2000059:negative regulation of ubiquitin-dependent protein catabolic process

0043065:positive regulation of apoptotic process

0005794:Golgi apparatus

0050771:negative regulation of axonogenesis

0016485:protein processing

0030054:cell junction

0045296:cadherin binding

0005654:nucleoplasm

0043025:neuronal cell body

0000186:activation of MAPKK activity

0031594:neuromuscular junction

0006974:cellular response to DNA damage stimulus

PDB 2KR6 ; 5FN5 ; 5FN3 ; 5FN2 ; 6IYC ; 4UIS ; 6IDF ; 5A63 ; 5FN4
Drugbank NA
KEGG hsa:5663

Related Compounds  (Total: 3)

Go to browser
C0363
Name: Resveratrol
Go to browser
C0855
Name: Acetylcysteine
Go to browser
C1265
Name: Curcumin


Related Herbs  (Total: 35)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0416 Shan Shen山参 NAPanax ginseng
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0142 Liang Jiang良姜 NAAlpinia officinarum
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0938 Da Suan大蒜 GarlicAllium sativum
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0357 Ren Shen人参 GinsengPanax ginseng
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum