HIT-result

Target Description

Type	Detail
Target ID	T81X6W
Protein Name	Endoplasmin
Uniprot ID	P14625
Protein Name Alias	94 kDa glucose-regulated protein; GRP-94; Heat shock protein 90 kDa beta member 1; Tumor rejection antigen 1; gp96 homolog
Gene ID	7184
Gene Symbol	HSP90B1
Gene Alias	GRP94; TRA1
TTD	T81311: Clinical Trial target
Pfam	PF02518 ; PF00183
GO	0071682:endocytic vesicle lumen 0005634:nucleus 0070062:extracellular exosome 0034976:response to endoplasmic reticulum stress 0005925:focal adhesion 0016887:ATPase activity 0005789:endoplasmic reticulum membrane 0005829:cytosol 0030433:ubiquitin-dependent ERAD pathway 0044267:cellular protein metabolic process 0034975:protein folding in endoplasmic reticulum 0030970:retrograde protein transport, ER to cytosol 0006457:protein folding 0001666:response to hypoxia 0033018:sarcoplasmic reticulum lumen 0043687:post-translational protein modification 0006898:receptor-mediated endocytosis 0005509:calcium ion binding 0002224:toll-like receptor signaling pathway 0005524:ATP binding 0005783:endoplasmic reticulum 0050750:low-density lipoprotein particle receptor binding 0048471:perinuclear region of cytoplasm 0030496:midbody 0051208:sequestering of calcium ion 0031247:actin rod assembly 0015031:protein transport 0051082:unfolded protein binding 0036500:ATF6-mediated unfolded protein response 0016020:membrane 0003723:RNA binding 0032991:protein-containing complex 0042470:melanosome 0062023:collagen-containing extracellular matrix 0005576:extracellular region 0043666:regulation of phosphoprotein phosphatase activity 0019221:cytokine-mediated signaling pathway 0071318:cellular response to ATP 0019903:protein phosphatase binding 0043066:negative regulation of apoptotic process 0005788:endoplasmic reticulum lumen
PDB	4NH9
Drugbank	DB03758 ; DB03719 ; DB08465 ; DB02103 ; DB00615 ; DB08464 ; DB02935 ; DB02424 ; DB09130
KEGG	hsa:7184

Type

Detail

Target ID

T81X6W

Protein Name

Endoplasmin

Uniprot ID

P14625

Protein Name Alias

94 kDa glucose-regulated protein; GRP-94; Heat shock protein 90 kDa beta member 1; Tumor rejection antigen 1; gp96 homolog

Gene ID

7184

Gene Symbol

HSP90B1

Gene Alias

GRP94; TRA1

TTD

T81311: Clinical Trial target

Pfam

PF02518 ; PF00183

0071682:endocytic vesicle lumen

0005634:nucleus

0070062:extracellular exosome

0034976:response to endoplasmic reticulum stress

0005925:focal adhesion

0016887:ATPase activity

0005789:endoplasmic reticulum membrane

0005829:cytosol

0030433:ubiquitin-dependent ERAD pathway

0044267:cellular protein metabolic process

0034975:protein folding in endoplasmic reticulum

0030970:retrograde protein transport, ER to cytosol

0006457:protein folding

0001666:response to hypoxia

0033018:sarcoplasmic reticulum lumen

0043687:post-translational protein modification

0006898:receptor-mediated endocytosis

0005509:calcium ion binding

0002224:toll-like receptor signaling pathway

0005524:ATP binding

0005783:endoplasmic reticulum

0050750:low-density lipoprotein particle receptor binding

0048471:perinuclear region of cytoplasm

0030496:midbody

0051208:sequestering of calcium ion

0031247:actin rod assembly

0015031:protein transport

0051082:unfolded protein binding

0036500:ATF6-mediated unfolded protein response

0016020:membrane

0003723:RNA binding

0032991:protein-containing complex

0042470:melanosome

0062023:collagen-containing extracellular matrix

0005576:extracellular region

0043666:regulation of phosphoprotein phosphatase activity

0019221:cytokine-mediated signaling pathway

0071318:cellular response to ATP

0019903:protein phosphatase binding

0043066:negative regulation of apoptotic process

0005788:endoplasmic reticulum lumen

PDB

4NH9

Drugbank

DB03758 ; DB03719 ; DB08465 ; DB02103 ; DB00615 ; DB08464 ; DB02935 ; DB02424 ; DB09130

KEGG

hsa:7184

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0707	Yuan Hua	芫花	Lilac daphne	Daphne genkwa
H0146	Liao Ge Wang	了哥王	NA	Wikstroemia indica
H0708	Yuan Hua Gen	芫花根	Lilac daphne root	Daphne genkwa
H0711	Yuan Hua Zhi Tiao	芫花枝条	stem of lilac daphne	Daphne genkwa
H0710	Yuan Hua Tiao	芫花条	stem of lilac daphne	Daphne genkwa
H0918	Cu Yuan Hua	醋芫花	Lilac daphne	Daphne genkwa
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H0185	Luo Shi Teng	络石藤	Chinese star jasmine	Trachelospermum jasminoides
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0289	Niu Bang Zi	牛蒡子	Great burdock fruit	Arctium lappa
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H0139	Lian Qiao	连翘	Weeping forsythia	Forsythia suspensa
H0614	Wu Zhao Long	五爪龙	Cairo morningglory	Ipomoea cairica
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0731	Ye Mei Gui Guo	野玫瑰果	Rosehips	Rosa canina
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 18)