HIT-result

Target Description

Type	Detail
Target ID	T37PX5
Protein Name	Zinc finger protein GLI1
Uniprot ID	P08151
Protein Name Alias	Glioma-associated oncogene; Oncogene GLI
Gene ID	2735
Gene Symbol	GLI1
Gene Alias	GLI
TTD	T40890: Patented target
Pfam	PF00096
GO	0009954:proximal/distal pattern formation 0000976:transcription regulatory region sequence-specific DNA binding 0021696:cerebellar cortex morphogenesis 0007224:smoothened signaling pathway 0008589:regulation of smoothened signaling pathway 0090090:negative regulation of canonical Wnt signaling pathway 0045740:positive regulation of DNA replication 0005930:axoneme 0003682:chromatin binding 0046872:metal ion binding 0005829:cytosol 0097546:ciliary base 0009611:response to wounding 0030850:prostate gland development 0000977:RNA polymerase II transcription regulatory region sequence-specific DNA binding 0007283:spermatogenesis 0005654:nucleoplasm 0043565:sequence-specific DNA binding 0030324:lung development 0060045:positive regulation of cardiac muscle cell proliferation 0005737:cytoplasm 0003677:DNA binding 0048546:digestive tract morphogenesis 0001649:osteoblast differentiation 0045893:positive regulation of transcription, DNA-templated 2000345:regulation of hepatocyte proliferation 0045880:positive regulation of smoothened signaling pathway 0007418:ventral midline development 0021983:pituitary gland development 0030335:positive regulation of cell migration 0021938:smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation 0045944:positive regulation of transcription by RNA polymerase II 0009913:epidermal cell differentiation 0005634:nucleus 0008284:positive regulation of cell population proliferation 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0097421:liver regeneration 1902808:positive regulation of cell cycle G1/S phase transition 0008017:microtubule binding 0060032:notochord regression 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0009953:dorsal/ventral pattern formation 0097542:ciliary tip 0060070:canonical Wnt signaling pathway 0045667:regulation of osteoblast differentiation 0006357:regulation of transcription by RNA polymerase II
PDB	4KMD ; 5OM0 ; 4BLB ; 2GLI
Drugbank	NA
KEGG	hsa:2735

Type

Detail

Target ID

T37PX5

Protein Name

Zinc finger protein GLI1

Uniprot ID

P08151

Protein Name Alias

Glioma-associated oncogene; Oncogene GLI

Gene ID

2735

Gene Symbol

GLI1

Gene Alias

GLI

TTD

T40890: Patented target

Pfam

PF00096

0009954:proximal/distal pattern formation

0000976:transcription regulatory region sequence-specific DNA binding

0021696:cerebellar cortex morphogenesis

0007224:smoothened signaling pathway

0008589:regulation of smoothened signaling pathway

0090090:negative regulation of canonical Wnt signaling pathway

0045740:positive regulation of DNA replication

0005930:axoneme

0003682:chromatin binding

0046872:metal ion binding

0005829:cytosol

0097546:ciliary base

0009611:response to wounding

0030850:prostate gland development

0000977:RNA polymerase II transcription regulatory region sequence-specific DNA binding

0007283:spermatogenesis

0005654:nucleoplasm

0043565:sequence-specific DNA binding

0030324:lung development

0060045:positive regulation of cardiac muscle cell proliferation

0005737:cytoplasm

0003677:DNA binding

0048546:digestive tract morphogenesis

0001649:osteoblast differentiation

0045893:positive regulation of transcription, DNA-templated

2000345:regulation of hepatocyte proliferation

0045880:positive regulation of smoothened signaling pathway

0007418:ventral midline development

0021983:pituitary gland development

0030335:positive regulation of cell migration

0021938:smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

0045944:positive regulation of transcription by RNA polymerase II

0009913:epidermal cell differentiation

0005634:nucleus

0008284:positive regulation of cell population proliferation

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0097421:liver regeneration

1902808:positive regulation of cell cycle G1/S phase transition

0008017:microtubule binding

0060032:notochord regression

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0009953:dorsal/ventral pattern formation

0097542:ciliary tip

0060070:canonical Wnt signaling pathway

0045667:regulation of osteoblast differentiation

0006357:regulation of transcription by RNA polymerase II

PDB

4KMD ; 5OM0 ; 4BLB ; 2GLI

Drugbank

KEGG

hsa:2735

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0199	Bei Dou Gen	北豆根	Chinese cinquefoil	Menispermum dauricum
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0968	Di Feng Pi	地枫皮	Difengpi anisetree	Illicium difengpi
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0728	Ye Jiang	野姜	NA	Zingiber cassumunar
H0214	Bei He Huan	北合欢	Albizia	Albizia julibrissin
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0532	Teng Huang	藤黄	Gamboge tree resin	Garcinia morella
H0416	Shan Shen	山参	NA	Panax ginseng
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena

Target Description

Related Compounds (Total: 8)

Related Herbs (Total: 41)