HIT-result

Target Description

Type	Detail
Target ID	T84FV7
Protein Name	Zinc finger protein SNAI2
Uniprot ID	O43623
Protein Name Alias	Neural crest transcription factor Slug; Protein snail homolog 2
Gene ID	6591
Gene Symbol	SNAI2
Gene Alias	SLUG; SLUGH
TTD	NA
Pfam	PF00096
GO	2001240:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 0005634:nucleus 0060429:epithelium development 0032331:negative regulation of chondrocyte differentiation 0014032:neural crest cell development 0043565:sequence-specific DNA binding 0030335:positive regulation of cell migration 0006355:regulation of transcription, DNA-templated 0071364:cellular response to epidermal growth factor stimulus 0010957:negative regulation of vitamin D biosynthetic process 0061314:Notch signaling involved in heart development 0010839:negative regulation of keratinocyte proliferation 0005737:cytoplasm 0000977:RNA polymerase II transcription regulatory region sequence-specific DNA binding 0032642:regulation of chemokine production 0001837:epithelial to mesenchymal transition 2000810:regulation of bicellular tight junction assembly 0003198:epithelial to mesenchymal transition involved in endocardial cushion formation 0007605:sensory perception of sound 0000785:chromatin 0043518:negative regulation of DNA damage response, signal transduction by p53 class mediator 0070888:E-box binding 0003180:aortic valve morphogenesis 0033629:negative regulation of cell adhesion mediated by integrin 0001649:osteoblast differentiation 0035921:desmosome disassembly 1902230:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 0070563:negative regulation of vitamin D receptor signaling pathway 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 2000811:negative regulation of anoikis 0007219:Notch signaling pathway 0000122:negative regulation of transcription by RNA polymerase II 0003273:cell migration involved in endocardial cushion formation 0045667:regulation of osteoblast differentiation 0090090:negative regulation of canonical Wnt signaling pathway 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0005654:nucleoplasm 0001227:DNA-binding transcription repressor activity, RNA polymerase II-specific 0046872:metal ion binding 1990837:sequence-specific double-stranded DNA binding 0043473:pigmentation
PDB	NA
Drugbank	NA
KEGG	hsa:6591

Type

Detail

Target ID

T84FV7

Protein Name

Zinc finger protein SNAI2

Uniprot ID

O43623

Protein Name Alias

Neural crest transcription factor Slug; Protein snail homolog 2

Gene ID

6591

Gene Symbol

SNAI2

Gene Alias

SLUG; SLUGH

TTD

Pfam

PF00096

2001240:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

0005634:nucleus

0060429:epithelium development

0032331:negative regulation of chondrocyte differentiation

0014032:neural crest cell development

0043565:sequence-specific DNA binding

0030335:positive regulation of cell migration

0006355:regulation of transcription, DNA-templated

0071364:cellular response to epidermal growth factor stimulus

0010957:negative regulation of vitamin D biosynthetic process

0061314:Notch signaling involved in heart development

0010839:negative regulation of keratinocyte proliferation

0005737:cytoplasm

0000977:RNA polymerase II transcription regulatory region sequence-specific DNA binding

0032642:regulation of chemokine production

0001837:epithelial to mesenchymal transition

2000810:regulation of bicellular tight junction assembly

0003198:epithelial to mesenchymal transition involved in endocardial cushion formation

0007605:sensory perception of sound

0000785:chromatin

0043518:negative regulation of DNA damage response, signal transduction by p53 class mediator

0070888:E-box binding

0003180:aortic valve morphogenesis

0033629:negative regulation of cell adhesion mediated by integrin

0001649:osteoblast differentiation

0035921:desmosome disassembly

1902230:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

0070563:negative regulation of vitamin D receptor signaling pathway

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

2000811:negative regulation of anoikis

0007219:Notch signaling pathway

0000122:negative regulation of transcription by RNA polymerase II

0003273:cell migration involved in endocardial cushion formation

0045667:regulation of osteoblast differentiation

0090090:negative regulation of canonical Wnt signaling pathway

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0005654:nucleoplasm

0001227:DNA-binding transcription repressor activity, RNA polymerase II-specific

0046872:metal ion binding

1990837:sequence-specific double-stranded DNA binding

0043473:pigmentation

PDB

Drugbank

KEGG

hsa:6591

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0006	Bai Qu Cai	白屈菜	Greater celandine	Chelidonium majus
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 8)