Target Description

Type Detail
Target ID T28HOM
Protein Name Leptin
Uniprot ID P41159
Protein Name Alias Obese protein;  Obesity factor
Gene ID 3952
Gene Symbol LEP
Gene Alias OB;  OBS
TTD T79485: Research target
Pfam PF02024
GO
0035630:bone mineralization involved in bone maturation

0006629:lipid metabolic process

1904651:positive regulation of fat cell apoptotic process

0060612:adipose tissue development

0045906:negative regulation of vasoconstriction

0050796:regulation of insulin secretion

0001934:positive regulation of protein phosphorylation

0032099:negative regulation of appetite

0061037:negative regulation of cartilage development

0001542:ovulation from ovarian follicle

0043410:positive regulation of MAPK cascade

0042445:hormone metabolic process

0032735:positive regulation of interleukin-12 production

0001936:regulation of endothelial cell proliferation

1900015:regulation of cytokine production involved in inflammatory response

0032760:positive regulation of tumor necrosis factor production

0005576:extracellular region

0051897:positive regulation of protein kinase B signaling

0033686:positive regulation of luteinizing hormone secretion

0033210:leptin-mediated signaling pathway

0007565:female pregnancy

0032869:cellular response to insulin stimulus

0042531:positive regulation of tyrosine phosphorylation of STAT protein

0050810:regulation of steroid biosynthetic process

0060587:regulation of lipoprotein lipid oxidation

0019953:sexual reproduction

0010507:negative regulation of autophagy

0032755:positive regulation of interleukin-6 production

0006909:phagocytosis

0006006:glucose metabolic process

0046325:negative regulation of glucose import

0042307:positive regulation of protein import into nucleus

0032310:prostaglandin secretion

0042102:positive regulation of T cell proliferation

0035556:intracellular signal transduction

0032814:regulation of natural killer cell activation

0098868:bone growth

0001666:response to hypoxia

0030217:T cell differentiation

0051726:regulation of cell cycle

0045471:response to ethanol

0090335:regulation of brown fat cell differentiation

0007260:tyrosine phosphorylation of STAT protein

0042755:eating behavior

0003677:DNA binding

0051428:peptide hormone receptor binding

0046850:regulation of bone remodeling

0021954:central nervous system neuron development

0032868:response to insulin

1990051:activation of protein kinase C activity

0005829:cytosol

0001525:angiogenesis

0032757:positive regulation of interleukin-8 production

0046427:positive regulation of receptor signaling pathway via JAK-STAT

0006111:regulation of gluconeogenesis

0008217:regulation of blood pressure

0005179:hormone activity

0006114:glycerol biosynthetic process

0035360:positive regulation of peroxisome proliferator activated receptor signaling pathway

0008343:adult feeding behavior

0035904:aorta development

0032008:positive regulation of TOR signaling

0043066:negative regulation of apoptotic process

0071298:cellular response to L-ascorbic acid

0030073:insulin secretion

0002021:response to dietary excess

0051541:elastin metabolic process

0000122:negative regulation of transcription by RNA polymerase II

0046881:positive regulation of follicle-stimulating hormone secretion

0030300:regulation of intestinal cholesterol absorption

0120162:positive regulation of cold-induced thermogenesis

0050892:intestinal absorption

0071300:cellular response to retinoic acid

0008206:bile acid metabolic process

0070093:negative regulation of glucagon secretion

0050901:leukocyte tethering or rolling

2000379:positive regulation of reactive oxygen species metabolic process

0038108:negative regulation of appetite by leptin-mediated signaling pathway

0010888:negative regulation of lipid storage

2000486:negative regulation of glutamine transport

0032355:response to estradiol

0046628:positive regulation of insulin receptor signaling pathway

0032817:regulation of natural killer cell proliferation

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0008203:cholesterol metabolic process

0042269:regulation of natural killer cell mediated cytotoxicity

0008340:determination of adult lifespan

0007623:circadian rhythm

0006635:fatty acid beta-oxidation

0042593:glucose homeostasis

0014823:response to activity

0005615:extracellular space

0045765:regulation of angiogenesis

0033197:response to vitamin E

1900745:positive regulation of p38MAPK cascade

0050999:regulation of nitric-oxide synthase activity

0044320:cellular response to leptin stimulus

0006112:energy reserve metabolic process

0048639:positive regulation of developmental growth

1990460:leptin receptor binding

0001890:placenta development

0003300:cardiac muscle hypertrophy

2000491:positive regulation of hepatic stellate cell activation

PDB 1AX8
Drugbank NA
KEGG hsa:3952

Related Compounds  (Total: 14)

Go to browser
C0055
Name: Estradiol
Go to browser
C0210
Name: Melatonin
Go to browser
C0255
Name: Norepinephrine
Go to browser
C0327
Name: Propranolol
Go to browser
C0363
Name: Resveratrol


Related Herbs  (Total: 164)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0603 Wu Tong Ye Jin Gao梧桐叶浸膏 Parasol treesFirmiana simplex
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0521 Tai Pan Zu Zhi Fen胎盘组织粉 NAHuman placenta
H1228 Huang Bai黄柏 Amur corktreePhellodendron amurense
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0043 Jie Zi芥子 India mustard seedBrassica juncea
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H0418 Shan Yin Chen山茵陈 Capillary wormwoodArtemisia capillaris
H0142 Liang Jiang良姜 NAAlpinia officinarum
H0365 Rou Dou Kou肉豆蔻 Common nutmegMyristica fragrans
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0720 Yang Jin Hua洋金花 Hindu datura flowerDatura metel
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H1231 Huang Bai Tan黄柏炭 Amur corktreePhellodendron amurense
H0297 Niu Xi牛膝 Twotooth achyranthesAchyranthes bidentata
H1176 Hei Hu Jiao黑胡椒 Black pepperPiper nigrum
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0732 Ye Mu Dan野牡丹 Common melastomaMelastoma candidum
H0547 Cang Qing Guo藏青果 MyrobalanTerminalia chebula
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H1241 Huang Lian黄连 Coptis deltoideaCoptis chinensis
H1181 Hei Zhi Ma黑芝麻 Oriental sesameSesamum indicum
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H1115 Guan Huang Bai关黄柏 Amur cork treePhellodendron amurense
H0760 Yu Huang Lian萸黄连 Coptis deltoideaCoptis chinensis
H0960 Dang Shen Qing Gao党参清膏 Root of hairy asiabellCodonopsis pilosula
H1004 Bai Cha白茶 White teaCamellia sinensis
H1068 Bai He Liu Jin Gao百合流浸膏 LilyLilium brownii
H0416 Shan Shen山参 NAPanax ginseng
H0652 Xiang Yuan Pi香橼皮 Wilson citronCitrus medica
H0296 Niu Teng牛藤 twotooth achyranthes rootAchyranthes bidentata
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0077 Jiu EthanolVinum
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H1208 Hu Ma Ren胡麻仁 white seed of oriental sesameSesamum indicum
H1207 Hu Ma胡麻 white seed of oriental sesameSesamum indicum
H0341 Qing Feng Teng青风藤 OrientvineSinomenium acutum
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H1230 Huang Bai Fen黄柏粉 Amur corktreePhellodendron amurense
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0709 Chang Shan常山 Antifebrile dichroaDichroa febrifuga
H0293 Niu Jiao Tan牛角炭 Buffalo hornBubalus bubalis
H1171 He Zi Rou诃子肉 Medicine terminaliaTerminalia chebula
H0082 Jiu Huang Lian酒黄连 Coptis deltoideaCoptis chinensis
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0318 Pu Tao(1)蒲桃 SyzygiumSyzygium jambos
H0522 Tai Zi Shen太子参 Heterophylly falsestarwort rootRadix pseudostellariae
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H0958 Dang Shen党参 Pilose asiabellCodonopsis pilosula
H1242 Huang Lian Gan Jin Gao黄连干浸膏 Coptis deltoideaCoptis chinensis
H0938 Da Suan大蒜 GarlicAllium sativum
H0291 Niu Jiao Fen牛角粉 Buffalo hornBubalus bubalis
H0615 Wu Zhi Mao Tao五指毛桃 five-finger fig rootFicus simplicissima
H0351 Quan Shen拳参 BistortPolygonum bistorta
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0405 Shan Dou Gen山豆根 Tonkin sophora rootSophora subprostrata
H0356 Ren Gong She Xiang人工麝香 AbelmuskMoschus moschiferus
H0085 Jiu Yu Rou酒萸肉 Asiatic cornelian cherryCornus officinalis
H0704 Yan Guan Huang Bai盐关黄柏 Amur cork treePhellodendron amurense
H0332 Qiao Mai荞麦 Common buckwheatFagopyrum esculentum
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H0427 Shan Zhu Yu山茱萸 Asiatic cornelian cherryCornus officinalis
H0987 Bai Bu Jin Gao百部浸膏 Tuber stemonaStemona tuberosa
H0661 Xiao Hei Dou小黑豆 Black turtle beanPhaseolus vulgaris
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0125 Lai Fu莱菔 Garden radishRaphanus sativus
H0679 Xing Ren杏仁 Apricot seedPrunus armeniaca
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0029 Jiang Huang Lian姜黄连 Coptis deltoideaCoptis chinensis
H0643 Xiang Jiao橡胶 RubberMusa paradisiaca var. sapientum
H0520 Tai Pan Fen胎盘粉 Fetus powderHuman placenta
H0881 Chuan Qiang Huo川羌活 Incised notopterygiumNotopterygium incisum
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0357 Ren Shen人参 GinsengPanax ginseng
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0275 Mu Zei木贼 Common scouring rushEquisetum hiemale
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H1033 Fang Ji防己 Fourstamen stephaniaStephania tetrandra
H0236 Mao She Xiang Jin Gao毛麝香浸膏 AbelmuskMoschus moschiferus
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0216 Man Jing Ye蔓荆叶 Threeleaf chastetree leafVitex trifolia
H0292 Niu Jiao Jian Fen牛角尖粉 Buffalo hornBubalus bubalis
H1077 Bai Hu Jiao白胡椒 white pepperPiper nigrum
H0925 Da Fu Zi大腹子 Areca palmAreca catechu
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H0967 Di Er Cao地耳草 Japanese stJohn’swortHypericum japonicum
H0585 Tu Yin Chen Hao土茵陈蒿 Capillary wormwoodArtemisia capillaris
H0408 Bing Lang槟榔 BetenutpalmAreca catechu
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0706 Yan Hu Suo延胡索 YanhusuoCorydalis yanhusuo
H0235 Mao She Xiang毛麝香 AbelmuskMoschus moschiferus
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H0962 Dao Dou刀豆 Sword jackbeanCanavalia gladiata
H1170 He Zi诃子 Medicine terminaliaTerminalia chebula
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0745 Yin Chen Hao茵陈蒿 Capillary wormwoodArtemisia capillaris
H0437 She Xiang麝香 AbelmuskMoschus moschiferus
H0217 Man Jing Zi蔓荆子 Threeleaf chastetree fruitVitex trifolia
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H0256 Ming Dang Shen明党参 Medicinal changiumChangium smyrnioides
H0126 Lai Fu Zi莱菔子 Garden radish seedRaphanus sativus
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H1212 Hu Ye Gan Jin Gao槲叶干浸膏 NAQuercus dentata
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0872 Chuan Huang Lian川黄连 rhizome of chinese goldthreadCoptis chinensis
H0746 Yin Chen Hao Gan Jin Gao茵陈蒿干浸膏 Capillary wormwoodArtemisia capillaris
H1243 Huang Lian Xu黄连须 Coptis deltoideaCoptis chinensis
H0682 Xiong Huang Lian雄黄连 Coptis deltoideaCoptis chinensis
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0331 Qiang Huo羌活 Incised notopterygiumNotopterygium incisum
H0489 Shui Niu Jiao Nong Suo Fen水牛角浓缩粉 Buffalo hornBubalus bubalis
H0224 Man Tuo Luo Ye曼陀罗叶 Hindu datura leafDatura metel
H0982 Bai Bu Gan Gao百部干膏 Tuber stemonaStemona tuberosa
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0827 Zhu Hong Jun竹红菌 Bambusa hypocrella*Hypocrella bambusae
H0977 Bai Bu百部 Tuber stemonaStemona tuberosa
H0087 Ju Gu Ye枸骨叶 FOLIUM iLICIS cORNUTAEIlex cornuta
H1029 Fang Er Cha方儿茶 khair in hindiSenegalia catechu
H0488 Shui Niu Jiao Gan Jin Gao水牛角干浸膏 Buffalo hornBubalus bubalis
H0225 Man Tuo Luo Zi曼陀罗子 Hindu datura seedDatura metel
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0214 Bei He Huan北合欢 AlbiziaAlbizia julibrissin
H0991 Bai Bu Liu Jin Gao百部流浸膏 Tuber stemonaStemona tuberosa
H0785 Ze Xi Huang Lian择细黄连 Coptis deltoideaCoptis chinensis
H0651 Xiang Yuan香橼 Wilson citronCitrus medica
H0466 Cai Fu Zi菜菔子 Semen raphaniRaphanus sativus
H0006 Bai Qu Cai白屈菜 Greater celandineChelidonium majus
H0633 Xia Tian Wu夏天无 Decumbent corydalisCorydalis decumbens
H0487 Shui Niu Jiao水牛角 Buffalo hornBubalus bubalis
H1061 Bai He百合 LilyLilium brownii
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H1204 Hu Jiao胡椒 Black pepperPiper nigrum
H0464 Shi Liu Zi石榴子 NAPunica granatum