HIT-result

Target Description

Type	Detail
Target ID	T41SFE
Protein Name	Histone acetyltransferase p300
Uniprot ID	Q09472
Protein Name Alias	p300 HAT; EC 2.3.1.48; E1A-associated protein p300; Histone butyryltransferase p300; EC 2.3.1.-; Histone crotonyltransferase p300; EC 2.3.1.-; Protein 2-hydroxyisobutyryltransferase p300; EC 2.3.1.-; Protein lactyltransferas p300; EC 2.3.1.-; Protein propionyltransferase p300; EC 2.3.1.-
Gene ID	2033
Gene Symbol	EP300
Gene Alias	P300
TTD	T25956: Clinical Trial target
Pfam	PF00439 ; PF06001 ; PF00569 ; PF09030 ; PF02172 ; PF08214 ; PF02135
GO	0006283:transcription-coupled nucleotide-excision repair 0001102:RNA polymerase II activating transcription factor binding 0003684:damaged DNA binding 0061418:regulation of transcription from RNA polymerase II promoter in response to hypoxia 0035257:nuclear hormone receptor binding 0007519:skeletal muscle tissue development 0016579:protein deubiquitination 0008134:transcription factor binding 1901796:regulation of signal transduction by p53 class mediator 0030522:intracellular receptor signaling pathway 0003682:chromatin binding 0003713:transcription coactivator activity 0018076:N-terminal peptidyl-lysine acetylation 0106226:peptide 2-hydroxyisobutyryltransferase activity 0010485:H4 histone acetyltransferase activity 0001756:somitogenesis 0007219:Notch signaling pathway 0006475:internal protein amino acid acetylation 0030324:lung development 0140069:histone butyryltransferase activity 0050681:androgen receptor binding 0061921:peptidyl-lysine propionylation 0061920:protein propionyltransferase activity 0001085:RNA polymerase II transcription factor binding 0007623:circadian rhythm 0042771:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 0140066:peptidyl-lysine crotonylation 0005694:chromosome 0032481:positive regulation of type I interferon production 0006355:regulation of transcription, DNA-templated 0140068:histone crotonyltransferase activity 0032993:protein-DNA complex 0007399:nervous system development 0051091:positive regulation of DNA-binding transcription factor activity 0006977:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 0045747:positive regulation of Notch signaling pathway 1905636:positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding 0097677:STAT family protein binding 0060765:regulation of androgen receptor signaling pathway 0030220:platelet formation 0140067:peptidyl-lysine butyrylation 0001666:response to hypoxia 0010821:regulation of mitochondrion organization 0140065:peptide butyryltransferase activity 0034644:cellular response to UV 0002223:stimulatory C-type lectin receptor signaling pathway 0036268:swimming 0051059:NF-kappaB binding 0050821:protein stabilization 0006915:apoptotic process 0030851:granulocyte differentiation 0007221:positive regulation of transcription of Notch receptor target 0051726:regulation of cell cycle 0001966:thigmotaxis 0004468:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor 0045815:positive regulation of gene expression, epigenetic 0030511:positive regulation of transforming growth factor beta receptor signaling pathway 0043967:histone H4 acetylation 0051092:positive regulation of NF-kappaB transcription factor activity 0031648:protein destabilization 0000122:negative regulation of transcription by RNA polymerase II 0060325:face morphogenesis 0006473:protein acetylation 0048156:tau protein binding 1900034:regulation of cellular response to heat 0010484:H3 histone acetyltransferase activity 0008013:beta-catenin binding 0016407:acetyltransferase activity 0016573:histone acetylation 0032092:positive regulation of protein binding 0045721:negative regulation of gluconeogenesis 0007507:heart development 0043627:response to estrogen 0006110:regulation of glycolytic process 0045444:fat cell differentiation 0043969:histone H2B acetylation 0035264:multicellular organism growth 0010742:macrophage derived foam cell differentiation 0005654:nucleoplasm 0033613:activating transcription factor binding 0000123:histone acetyltransferase complex 0002209:behavioral defense response 0003677:DNA binding 0002039:p53 binding 0008270:zinc ion binding 0045944:positive regulation of transcription by RNA polymerase II 0035855:megakaryocyte development 0005634:nucleus 0010976:positive regulation of neuron projection development 0030183:B cell differentiation 0045652:regulation of megakaryocyte differentiation 0010506:regulation of autophagy 0018394:peptidyl-lysine acetylation 0005667:transcription regulator complex 1901224:positive regulation of NIK/NF-kappaB signaling 0008022:protein C-terminus binding 0006990:positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response 0097157:pre-mRNA intronic binding 1904837:beta-catenin-TCF complex assembly 0018393:internal peptidyl-lysine acetylation 0005829:cytosol 0090043:regulation of tubulin deacetylation 0031490:chromatin DNA binding 0007611:learning or memory 0045893:positive regulation of transcription, DNA-templated 0004402:histone acetyltransferase activity 0016746:transferase activity, transferring acyl groups 0031333:negative regulation of protein-containing complex assembly 0009887:animal organ morphogenesis 0043923:positive regulation by host of viral transcription 0016032:viral process
PDB	5BT3 ; 6GYT ; 6PF1 ; 6V8K ; 3IO2 ; 2MZD ; 6FGN ; 5NU5 ; 5KJ2 ; 6K4N ; 3P57 ; 3I3J ; 3T92 ; 4PZS ; 6V8N ; 5XZC ; 4BHW ; 3BIY ; 5LPK ; 1L3E ; 2K8F ; 2MH0 ; 6PGU ; 4PZR ; 5LKZ ; 5LKU ; 1P4Q ; 5LKT ; 6GYR ; 6FGS ; 6V90 ; 4PZT ; 5LKX ; 6DS6 ; 5LPM ; 6V8B
Drugbank	NA
KEGG	hsa:2033

Type

Detail

Target ID

T41SFE

Protein Name

Histone acetyltransferase p300

Uniprot ID

Q09472

Protein Name Alias

p300 HAT; EC 2.3.1.48; E1A-associated protein p300; Histone butyryltransferase p300; EC 2.3.1.-; Histone crotonyltransferase p300; EC 2.3.1.-; Protein 2-hydroxyisobutyryltransferase p300; EC 2.3.1.-; Protein lactyltransferas p300; EC 2.3.1.-; Protein propionyltransferase p300; EC 2.3.1.-

Gene ID

2033

Gene Symbol

EP300

Gene Alias

P300

TTD

T25956: Clinical Trial target

Pfam

PF00439 ; PF06001 ; PF00569 ; PF09030 ; PF02172 ; PF08214 ; PF02135

0006283:transcription-coupled nucleotide-excision repair

0001102:RNA polymerase II activating transcription factor binding

0003684:damaged DNA binding

0061418:regulation of transcription from RNA polymerase II promoter in response to hypoxia

0035257:nuclear hormone receptor binding

0007519:skeletal muscle tissue development

0016579:protein deubiquitination

0008134:transcription factor binding

1901796:regulation of signal transduction by p53 class mediator

0030522:intracellular receptor signaling pathway

0003682:chromatin binding

0003713:transcription coactivator activity

0018076:N-terminal peptidyl-lysine acetylation

0106226:peptide 2-hydroxyisobutyryltransferase activity

0010485:H4 histone acetyltransferase activity

0001756:somitogenesis

0007219:Notch signaling pathway

0006475:internal protein amino acid acetylation

0030324:lung development

0140069:histone butyryltransferase activity

0050681:androgen receptor binding

0061921:peptidyl-lysine propionylation

0061920:protein propionyltransferase activity

0001085:RNA polymerase II transcription factor binding

0007623:circadian rhythm

0042771:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

0140066:peptidyl-lysine crotonylation

0005694:chromosome

0032481:positive regulation of type I interferon production

0006355:regulation of transcription, DNA-templated

0140068:histone crotonyltransferase activity

0032993:protein-DNA complex

0007399:nervous system development

0051091:positive regulation of DNA-binding transcription factor activity

0006977:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

0045747:positive regulation of Notch signaling pathway

1905636:positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding

0097677:STAT family protein binding

0060765:regulation of androgen receptor signaling pathway

0030220:platelet formation

0140067:peptidyl-lysine butyrylation

0001666:response to hypoxia

0010821:regulation of mitochondrion organization

0140065:peptide butyryltransferase activity

0034644:cellular response to UV

0002223:stimulatory C-type lectin receptor signaling pathway

0036268:swimming

0051059:NF-kappaB binding

0050821:protein stabilization

0006915:apoptotic process

0030851:granulocyte differentiation

0007221:positive regulation of transcription of Notch receptor target

0051726:regulation of cell cycle

0001966:thigmotaxis

0004468:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor

0045815:positive regulation of gene expression, epigenetic

0030511:positive regulation of transforming growth factor beta receptor signaling pathway

0043967:histone H4 acetylation

0051092:positive regulation of NF-kappaB transcription factor activity

0031648:protein destabilization

0000122:negative regulation of transcription by RNA polymerase II

0060325:face morphogenesis

0006473:protein acetylation

0048156:tau protein binding

1900034:regulation of cellular response to heat

0010484:H3 histone acetyltransferase activity

0008013:beta-catenin binding

0016407:acetyltransferase activity

0016573:histone acetylation

0032092:positive regulation of protein binding

0045721:negative regulation of gluconeogenesis

0007507:heart development

0043627:response to estrogen

0006110:regulation of glycolytic process

0045444:fat cell differentiation

0043969:histone H2B acetylation

0035264:multicellular organism growth

0010742:macrophage derived foam cell differentiation

0005654:nucleoplasm

0033613:activating transcription factor binding

0000123:histone acetyltransferase complex

0002209:behavioral defense response

0003677:DNA binding

0002039:p53 binding

0008270:zinc ion binding

0045944:positive regulation of transcription by RNA polymerase II

0035855:megakaryocyte development

0005634:nucleus

0010976:positive regulation of neuron projection development

0030183:B cell differentiation

0045652:regulation of megakaryocyte differentiation

0010506:regulation of autophagy

0018394:peptidyl-lysine acetylation

0005667:transcription regulator complex

1901224:positive regulation of NIK/NF-kappaB signaling

0008022:protein C-terminus binding

0006990:positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response

0097157:pre-mRNA intronic binding

1904837:beta-catenin-TCF complex assembly

0018393:internal peptidyl-lysine acetylation

0005829:cytosol

0090043:regulation of tubulin deacetylation

0031490:chromatin DNA binding

0007611:learning or memory

0045893:positive regulation of transcription, DNA-templated

0004402:histone acetyltransferase activity

0016746:transferase activity, transferring acyl groups

0031333:negative regulation of protein-containing complex assembly

0009887:animal organ morphogenesis

0043923:positive regulation by host of viral transcription

0016032:viral process

PDB

5BT3 ; 6GYT ; 6PF1 ; 6V8K ; 3IO2 ; 2MZD ; 6FGN ; 5NU5 ; 5KJ2 ; 6K4N ; 3P57 ; 3I3J ; 3T92 ; 4PZS ; 6V8N ; 5XZC ; 4BHW ; 3BIY ; 5LPK ; 1L3E ; 2K8F ; 2MH0 ; 6PGU ; 4PZR ; 5LKZ ; 5LKU ; 1P4Q ; 5LKT ; 6GYR ; 6FGS ; 6V90 ; 4PZT ; 5LKX ; 6DS6 ; 5LPM ; 6V8B

Drugbank

KEGG

hsa:2033

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1250	Huang Qi Ti Qu Ye	黄芪提取液	Membranous milkvetch	Astragalus membranaceus
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0277	Nan Ban Lan Gen	南板蓝根	Indigowoad root	Baphicacanthus cusia
H0026	Jiang	姜	Soybean paste	Glycine max
H1051	Bai Guo	白果	Ginkgo nut	Ginkgo biloba
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1007	Dou You	豆油	Soybean oil	Glycine max
H0108	Ku Lian Pi	苦楝皮	Chinaberry-tree bark	Melia azedarach
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H0301	Ou	藕	Hindu lotus large rhizome	Nelumbo nucifera
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H1152	Bai Jie Zi	白芥子	White mustard seed	Sinapis alba
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0304	Ou Pian	藕片	Hindu lotus large rhizome	Nelumbo nucifera
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H0018	Ji Xue Teng Gan Gao	鸡血藤干膏	Suberect spatholobus stem	Spatholobus suberectus
H0995	Dong Chong Xia Cao	冬虫夏草	Aweto	Cordyceps sinensis
H1247	Huang Qi	黄芪	Membranous milkvetch	Astragalus membranaceus
H0252	Mian Da Ji	绵大戟	NA	Euphorbia pekinensis
H1164	He Geng	荷梗	Hindu lotus petiole	Nelumbo nucifera
H0302	Ou Fen	藕粉	Hindu lotus large rhizome	Nelumbo nucifera
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H0140	Lian Zi	莲子	Hindu lotus seed	Nelumbo nucifera
H0019	Ji Xue Teng Gao	鸡血藤膏	Suberect spatholobus stem	Spatholobus suberectus
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0278	Nan Ban Lan Gen Jin Gao Fen	南板蓝根浸膏粉	Indigowoad root	Baphicacanthus cusia
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H0109	Ku Lian Zi	苦楝子	NA	Melia azedarach
H0897	Chuan Lian	川楝	Chinaberry	Melia azedarach
H1169	He Ye	荷叶	Hindu lotus leaf	Nelumbo nucifera
H0141	Lian Zi Xin	莲子心	Hindu lotus plumule	Nelumbo nucifera
H0981	Dian Ji Xue Teng Gao Fen	滇鸡血藤膏粉	Suberect spatholobus stem	Spatholobus suberectus
H0017	Ji Xue Teng	鸡血藤	Suberect spatholobus stem	Spatholobus suberectus
H1021	E Da Xia	莪大夏	NA	Oxytropis falcata
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1055	Bai Guo Ren	白果仁	ginkgo	Ginkgo biloba
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0750	Yin Xing Ye	银杏叶	Folium ginkgo	Ginkgo biloba
H0231	Mao Gao Cai	茅膏菜	Lunate peltate sundew	Drosera peltata var. lunata
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H1249	Huang Qi Jin Gao	黄芪浸膏	Membranous milkvetch	Astragalus membranaceus
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H0705	Yan Hu Lu Ba	盐胡芦巴	Fenugreek	Trigonella foenum-graecum
H1248	Huang Qi Gan Jin Gao	黄芪干浸膏	Membranous milkvetch	Astragalus membranaceus
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max
H0405	Shan Dou Gen	山豆根	Tonkin sophora root	Sophora subprostrata

Target Description

Related Compounds (Total: 7)

Related Herbs (Total: 64)