Target Description

Type Detail
Target ID T74D4Y
Protein Name CASP8 and FADD-like apoptosis regulator
Uniprot ID O15519
Protein Name Alias Caspase homolog;  CASH;  Caspase-eight-related protein;  Casper;  Caspase-like apoptosis regulatory protein;  CLARP;  Cellular FLICE-like inhibitory protein;  c-FLIP;  FADD-like antiapoptotic molecule 1;  FLAME-1;  Inhibitor of FLICE;  I-FLICE;  MACH-related inducer of toxicity;  MRIT;  Usurpin
Gene ID 8837
Gene Symbol CFLAR
Gene Alias CASH;  CASP8AP1;  CLARP;  MRIT
TTD T14306: Research target
Pfam PF01335
GO
1901740:negative regulation of myoblast fusion

1903427:negative regulation of reactive oxygen species biosynthetic process

0008047:enzyme activator activity

0060544:regulation of necroptotic process

0097200:cysteine-type endopeptidase activity involved in execution phase of apoptosis

0043066:negative regulation of apoptotic process

0007519:skeletal muscle tissue development

0097342:ripoptosome

2000347:positive regulation of hepatocyte proliferation

0014866:skeletal myofibril assembly

0072126:positive regulation of glomerular mesangial cell proliferation

0005829:cytosol

0097153:cysteine-type endopeptidase activity involved in apoptotic process

0071456:cellular response to hypoxia

0033574:response to testosterone

0031265:CD95 death-inducing signaling complex

0044877:protein-containing complex binding

0010667:negative regulation of cardiac muscle cell apoptotic process

0043403:skeletal muscle tissue regeneration

2001237:negative regulation of extrinsic apoptotic signaling pathway

0006915:apoptotic process

1903944:negative regulation of hepatocyte apoptotic process

0031264:death-inducing signaling complex

0014842:regulation of skeletal muscle satellite cell proliferation

0071549:cellular response to dexamethasone stimulus

0071732:cellular response to nitric oxide

0014732:skeletal muscle atrophy

0005737:cytoplasm

0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process

0071392:cellular response to estradiol stimulus

0032869:cellular response to insulin stimulus

1902041:regulation of extrinsic apoptotic signaling pathway via death domain receptors

1903845:negative regulation of cellular response to transforming growth factor beta stimulus

0002020:protease binding

0045121:membrane raft

0070374:positive regulation of ERK1 and ERK2 cascade

1903055:positive regulation of extracellular matrix organization

0071364:cellular response to epidermal growth factor stimulus

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0010976:positive regulation of neuron projection development

0042060:wound healing

0051092:positive regulation of NF-kappaB transcription factor activity

0005123:death receptor binding

0010803:regulation of tumor necrosis factor-mediated signaling pathway

0016032:viral process

1902042:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

0097199:cysteine-type endopeptidase activity involved in apoptotic signaling pathway

PDB 3H13 ; 2N5R ; 3H11
Drugbank NA
KEGG hsa:8837

Related Compounds  (Total: 7)

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C0363
Name: Resveratrol
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C0477
Name: Valproic Acid
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C0485
Name: Wogonin
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C0914
Name: Apigenin
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C1095
Name: saponin


Related Herbs  (Total: 223)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H0713 Che Qian Cao车前草 all-grass of rippleseed plantainPlantago depressa
H0613 Wu Yue Ai五月艾 ArtemisiaArtemisia princeps
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H0071 Bai Ye柏叶 Chinese arborvitae twigPlatycladus orientalis
H0802 Zhi Geng枳梗 NACitrus aurantium
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H1090 Gao Ben藁本 Chinese ligusticumLigusticum sinense
H1021 E Da Xia莪大夏 NAOxytropis falcata
H0357 Ren Shen人参 GinsengPanax ginseng
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H0818 Zhi Zi栀子 Cape jasmine fruitGardenia jasminoides
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H0074 Jing Jie Tan荆芥炭 NASchizonepetae herba
H1219 Hua Sheng Mi花生米 NAArachis hypogaea
H0727 Ye Gan Cao野甘草 Sweet broomwortScoparia dulcis
H0424 Shan Zhi山栀 Cape jasmineGardenia jasminoides
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0457 Shi Er石耳 Rock-EarsUmbilicaria esculenta
H0029 Jiang Huang Lian姜黄连 Coptis deltoideaCoptis chinensis
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0957 Dang Gui Teng当归藤 NAEmbelia parviflora
H0821 Chu Ling Dan Cao臭灵丹草 laggera pterodontaLaggera pterodonta
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium
H0142 Liang Jiang良姜 NAAlpinia officinarum
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0026 Jiang Soybean pasteGlycine max
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0659 Chai Hu Jin Gao柴胡浸膏 Chinese thorowaxBupleurum chinense
H0708 Yuan Hua Gen芫花根 Lilac daphne rootDaphne genkwa
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H1249 Huang Qi Jin Gao黄芪浸膏 Membranous milkvetchAstragalus membranaceus
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0089 Ju Hong橘红 NACitri exocarpium rubrum
H1107 Gua Lou Ren Shuang瓜蒌仁霜 NATrichosanthes kirilowii
H1138 Bai Jiang Cao败酱草 All - grass of dahurian patriniaThlaspi arvense
H0183 Luo Hua Sheng Zhi Ye落花生枝叶 Peanut branch-leafArachis hypogaea
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0185 Luo Shi Teng络石藤 Chinese star jasmineTrachelospermum jasminoides
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H1225 Huai Mi槐米 NASophora japonica
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0300 Nv Zhen Zi女贞子 Glossy privet fruitLigustrum lucidum
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H0568 Tu Er Cao兔耳草 LagotisLagotis brevituba
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0638 Xiang Bei象贝 FritillariaFritillaria thunbergii
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0920 Da Ban Bian Lian大半边莲 Asian lobeliaLobelia chinensis
H1133 Gui Jian Yu鬼箭羽 Winged euonymusEuonymus alatus
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H0901 Chun Gen Teng春根藤 Twig and leaf of creeping psychotriaPsychotria serpens
H0247 Mi Meng Hua密蒙花 Pale butterflybushBuddleja officinalis
H0855 Chuan Bei Mu川贝母 Fritillaria unibracteataFritillaria cirrhosa
H1227 Huai Zhi槐枝 NASophora japonica
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1247 Huang Qi黄芪 Membranous milkvetchAstragalus membranaceus
H0887 Chuan Xin Lian Gan Jin Gao穿心莲干浸膏 Common andrographisAndrographis paniculata
H1105 Gua Lou Pi瓜蒌皮 NATrichosanthes kirilowii
H0691 Xue Lian Hua雪莲花 Snow lotusSaussurea involucrata
H0696 Ya Jiao Ai鸭脚艾 Ghostplant wormwoodArtemisia lactiflora
H0692 Xue Ren Shen血人参 NALespedeza bicolor
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0974 Di Jin Cao地锦草 Humifuse euphorbiaEuphorbia humifusa
H0663 Xiao Ji小蓟 Setose thistleCirsium setosum
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0744 Yin Chai Hu银柴胡 Lanceolate starwortStellaria dichotoma var. lanceolata
H0551 Cang Zhu苍术 Swordlike atractylodesAtractylodes lancea
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H1218 Hua Sheng花生 NAArachis hypogaea
H0668 Xiao Ye Huang Yang小叶黄杨 Small-leaved boxBuxus microphylla
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H0711 Yuan Hua Zhi Tiao芫花枝条 stem of lilac daphneDaphne genkwa
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0353 Que Mei Teng Gen雀梅藤根 Hedge sageretiaSageretia thea
H0785 Ze Xi Huang Lian择细黄连 Coptis deltoideaCoptis chinensis
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H0580 Tu Si Rou菟丝肉 Dodder seedCuscuta australis
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0581 Tu Si Zi菟丝子 Dodder seedCuscuta australis
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H1030 Fang Feng防风 Divaricate saposhnikoviaSaposhnikovia divaricata
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0193 Ma Bian Cao马鞭草 European verbenaVerbena officinalis
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H0871 Chuan Duan川断 TeaselsDipsacus asper
H0100 Juan Bai卷柏 Tamariskoid spikemossSelaginella tamariscina
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H0918 Cu Yuan Hua醋芫花 Lilac daphneDaphne genkwa
H1242 Huang Lian Gan Jin Gao黄连干浸膏 Coptis deltoideaCoptis chinensis
H0152 Ling Zhi Jin Gao灵芝浸膏 NAGanoderma lucidum
H0665 Chai Hu Shao柴胡梢 Chinese thorowaxBupleurum chinense
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0889 Chuan Xin Lian Jin Gao穿心莲浸膏 Common andrographisAndrographis paniculata
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H1248 Huang Qi Gan Jin Gao黄芪干浸膏 Membranous milkvetchAstragalus membranaceus
H0218 Man Jiu Jie蔓九节 Creeping ninenodePsychotria serpens
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H0094 Gou Qi枸杞 Chinese wolfberry fruitLycium chinense
H1007 Dou You豆油 Soybean oilGlycine max
H0805 Zhi Ke Gan Jin Gao枳壳干浸膏 Seville ora nge unripe fruitCitrus aurantium
H0237 Mei Gui Hua玫瑰花 Rugose rose flowerRosa rugosa
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0583 Tu Si Zi Teng菟丝子藤 Dodder seedCuscuta australis
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H0130 Lei Gong Teng雷公藤 Common threewingnutTripterygium wilfordii
H0826 Chu Mu Dan臭牡丹 rose glorybowerClerodendrum bungei
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0819 Zhi Zi Jin Gao栀子浸膏 Cape jasmine fruitGardenia jasminoides
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H0664 Xiao Ji Tan小蓟炭 ThistleCirsium arvense
H0279 Nan Gua南瓜 CushawCucurbita moschata
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0760 Yu Huang Lian萸黄连 Coptis deltoideaCoptis chinensis
H0729 Ye Ju Hua野菊花 Indian wild chrysanthemum flowerChrysanthemum indicum
H0891 Chuan Xin Lian Ye穿心莲叶 Powder of green chiretta leavesAndrographis herba
H0682 Xiong Huang Lian雄黄连 Coptis deltoideaCoptis chinensis
H0370 Ru Xiang乳香 OlibanumBoswellia carterii
H1106 Gua Lou Ren瓜蒌仁 NATrichosanthes kirilowii
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H0886 Chuan Xin Lian穿心莲 Common andrographisAndrographis paniculata
H0872 Chuan Huang Lian川黄连 rhizome of chinese goldthreadCoptis chinensis
H0095 Gou Qi Zi枸杞子 Chinese wolfberry fruitLycium chinense
H0859 Chuan Bei Mu Liu Jin Gao川贝母流浸膏 Fritillaria unibracteataFritillaria cirrhosa
H1243 Huang Lian Xu黄连须 Coptis deltoideaCoptis chinensis
H0710 Yuan Hua Tiao芫花条 stem of lilac daphneDaphne genkwa
H0524 Tan Xiang檀香 SandalwoodSantalum album
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0714 Yan Tai Chai Hu烟台柴胡 Chinese thorowaxBupleurum chinense
H1241 Huang Lian黄连 Coptis deltoideaCoptis chinensis
H0816 Chu Ling Dan臭灵丹 laggera pterodontaLaggera pterodonta
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0498 Si Ji Cai四季菜 Ghostplant wormwoodArtemisia lactiflora
H0546 Tian Shan Xue Lian Hua天山雪莲花 NASaussurea involucrata
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0082 Jiu Huang Lian酒黄连 Coptis deltoideaCoptis chinensis
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0214 Bei He Huan北合欢 AlbiziaAlbizia julibrissin
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H0707 Yuan Hua芫花 Lilac daphneDaphne genkwa
H0284 Nan She Teng南蛇藤 Oriental bittersweetCelastrus orbiculatus
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H0072 Jing Jie荆芥 Fineleaf schizonepetaSchizonepeta tenuifolia
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0496 Shui Ze Lan水泽兰 NALycopus lucidus
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H1250 Huang Qi Ti Qu Ye黄芪提取液 Membranous milkvetchAstragalus membranaceus
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0642 Xiang Jia Pi香加皮 Chinese silkvine root-barkPeriploca sepium
H0890 Chuan Xin Lian Nong Suo Ye穿心莲浓缩液 Common andrographisAndrographis paniculata
H0975 Di Mian Cao地绵草 NAEuphorbia humifusa
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0153 Ling Zhi(1)灵芝 Lucid ganodermaGanoderma lucidum
H0073 Jing Jie Sui荆芥穗 NASchizonepetae spica
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0650 Chai Hu柴胡 Chinese thorowaxBupleurum chinense
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H1128 Bai Jiang败酱 Whiteflower patriniaPatrinia villosa
H1112 Gua Lou Ren(1)栝楼仁 NATrichosanthes kirilowii
H1141 Guo Gang Long Jin Gao过岗龙浸膏 NAEntada phaseoloides
H1140 Guo Gang Long过岗龙 NAEntada phaseoloides
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H0527 Tao PeachPrunus persica
H1104 Gua Lou瓜蒌 NATrichosanthes kirilowii
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H0113 Ban Bian Lian半边莲 Chinese lobeliaLobelia chinensis
H1111 Gua Lou Gen栝楼根 NATrichosanthes kirilowii
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0690 Xue Lian雪莲 Snow lotusSaussurea involucrata
H1108 Gua Lou Shi栝蒌实 NATrichosanthes kirilowii
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0416 Shan Shen山参 NAPanax ginseng
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H0539 Tian Hua Fen天花粉 Mongolian snakegourd rootTrichosanthes kirilowii
H0204 Ma Ren麻仁 NACannabis sativa