HIT-result

Type	Detail
Target ID	T74D4Y
Protein Name	CASP8 and FADD-like apoptosis regulator
Uniprot ID	O15519
Protein Name Alias	Caspase homolog; CASH; Caspase-eight-related protein; Casper; Caspase-like apoptosis regulatory protein; CLARP; Cellular FLICE-like inhibitory protein; c-FLIP; FADD-like antiapoptotic molecule 1; FLAME-1; Inhibitor of FLICE; I-FLICE; MACH-related inducer of toxicity; MRIT; Usurpin
Gene ID	8837
Gene Symbol	CFLAR
Gene Alias	CASH; CASP8AP1; CLARP; MRIT
TTD	T14306: Research target
Pfam	PF01335
GO	1901740:negative regulation of myoblast fusion 1903427:negative regulation of reactive oxygen species biosynthetic process 0008047:enzyme activator activity 0060544:regulation of necroptotic process 0097200:cysteine-type endopeptidase activity involved in execution phase of apoptosis 0043066:negative regulation of apoptotic process 0007519:skeletal muscle tissue development 0097342:ripoptosome 2000347:positive regulation of hepatocyte proliferation 0014866:skeletal myofibril assembly 0072126:positive regulation of glomerular mesangial cell proliferation 0005829:cytosol 0097153:cysteine-type endopeptidase activity involved in apoptotic process 0071456:cellular response to hypoxia 0033574:response to testosterone 0031265:CD95 death-inducing signaling complex 0044877:protein-containing complex binding 0010667:negative regulation of cardiac muscle cell apoptotic process 0043403:skeletal muscle tissue regeneration 2001237:negative regulation of extrinsic apoptotic signaling pathway 0006915:apoptotic process 1903944:negative regulation of hepatocyte apoptotic process 0031264:death-inducing signaling complex 0014842:regulation of skeletal muscle satellite cell proliferation 0071549:cellular response to dexamethasone stimulus 0071732:cellular response to nitric oxide 0014732:skeletal muscle atrophy 0005737:cytoplasm 0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process 0071392:cellular response to estradiol stimulus 0032869:cellular response to insulin stimulus 1902041:regulation of extrinsic apoptotic signaling pathway via death domain receptors 1903845:negative regulation of cellular response to transforming growth factor beta stimulus 0002020:protease binding 0045121:membrane raft 0070374:positive regulation of ERK1 and ERK2 cascade 1903055:positive regulation of extracellular matrix organization 0071364:cellular response to epidermal growth factor stimulus 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0010976:positive regulation of neuron projection development 0042060:wound healing 0051092:positive regulation of NF-kappaB transcription factor activity 0005123:death receptor binding 0010803:regulation of tumor necrosis factor-mediated signaling pathway 0016032:viral process 1902042:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 0097199:cysteine-type endopeptidase activity involved in apoptotic signaling pathway
PDB	3H13 ; 2N5R ; 3H11
Drugbank	NA
KEGG	hsa:8837

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Name: Resveratrol

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Name: Valproic Acid

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Name: Wogonin

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Name: Apigenin

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Name: saponin

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Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H1112	Gua Lou Ren(1)	栝楼仁	NA	Trichosanthes kirilowii
H0193	Ma Bian Cao	马鞭草	European verbena	Verbena officinalis
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H0816	Chu Ling Dan	臭灵丹	laggera pterodonta	Laggera pterodonta
H0198	Ma Huang Gao	麻黄膏	Chinese ephedra	Ephedra sinica
H0314	Pu Gong Ying	蒲公英	Mongolian dandelion	Taraxacum mongolicum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H1219	Hua Sheng Mi	花生米	NA	Arachis hypogaea
H0918	Cu Yuan Hua	醋芫花	Lilac daphne	Daphne genkwa
H1104	Gua Lou	瓜蒌	NA	Trichosanthes kirilowii
H1051	Bai Guo	白果	Ginkgo nut	Ginkgo biloba
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H1124	Guang Jin Qian Cao	广金钱草	Snowbellleaf tickclover	Desmodium styracifolium
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H1111	Gua Lou Gen	栝楼根	NA	Trichosanthes kirilowii
H0004	Huo Xiang	藿香	Patchouli	Pogostemon cablin
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0975	Di Mian Cao	地绵草	NA	Euphorbia humifusa
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H1140	Guo Gang Long	过岗龙	NA	Entada phaseoloides
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0887	Chuan Xin Lian Gan Jin Gao	穿心莲干浸膏	Common andrographis	Andrographis paniculata
H0707	Yuan Hua	芫花	Lilac daphne	Daphne genkwa
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0690	Xue Lian	雪莲	Snow lotus	Saussurea involucrata
H0310	Pian Qin	片芩	Scutellaria amoena	Scutellaria baicalensis
H0575	Tu Ku Shen	土苦参	all-grass of hooker winghead	Sophora flavescens
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0539	Tian Hua Fen	天花粉	Mongolian snakegourd root	Trichosanthes kirilowii
H1241	Huang Lian	黄连	Coptis deltoidea	Coptis chinensis
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H0300	Nv Zhen Zi	女贞子	Glossy privet fruit	Ligustrum lucidum
H1090	Gao Ben	藁本	Chinese ligusticum	Ligusticum sinense
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0353	Que Mei Teng Gen	雀梅藤根	Hedge sageretia	Sageretia thea
H0760	Yu Huang Lian	萸黄连	Coptis deltoidea	Coptis chinensis
H1252	Huang Qin Jin Gao	黄芩浸膏	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H1021	E Da Xia	莪大夏	NA	Oxytropis falcata
H0818	Zhi Zi	栀子	Cape jasmine fruit	Gardenia jasminoides
H0744	Yin Chai Hu	银柴胡	Lanceolate starwort	Stellaria dichotoma var. lanceolata
H0185	Luo Shi Teng	络石藤	Chinese star jasmine	Trachelospermum jasminoides
H0708	Yuan Hua Gen	芫花根	Lilac daphne root	Daphne genkwa
H0183	Luo Hua Sheng Zhi Ye	落花生枝叶	Peanut branch-leaf	Arachis hypogaea
H0246	Mi Ma Huang	蜜麻黄	Ephedra equisetin	Ephedra sinica
H0416	Shan Shen	山参	NA	Panax ginseng
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0891	Chuan Xin Lian Ye	穿心莲叶	Powder of green chiretta leaves	Andrographis herba
H0527	Tao	桃	Peach	Prunus persica
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H1138	Bai Jiang Cao	败酱草	All - grass of dahurian patrinia	Thlaspi arvense
H0279	Nan Gua	南瓜	Cushaw	Cucurbita moschata
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0003	Huo Ma Ren	火麻仁	Hemp fimble seed	Cannabis sativa
H0204	Ma Ren	麻仁	NA	Cannabis sativa
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H0802	Zhi Geng	枳梗	NA	Citrus aurantium
H0082	Jiu Huang Lian	酒黄连	Coptis deltoidea	Coptis chinensis
H1152	Bai Jie Zi	白芥子	White mustard seed	Sinapis alba
H0890	Chuan Xin Lian Nong Suo Ye	穿心莲浓缩液	Common andrographis	Andrographis paniculata
H0152	Ling Zhi Jin Gao	灵芝浸膏	NA	Ganoderma lucidum
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0804	Zhi Ke	枳壳	Seville ora nge unripe fruit	Citrus aurantium
H0805	Zhi Ke Gan Jin Gao	枳壳干浸膏	Seville ora nge unripe fruit	Citrus aurantium
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H0531	Tao Zhi	桃枝	Peach juvenile branch	Prunus persica
H1242	Huang Lian Gan Jin Gao	黄连干浸膏	Coptis deltoidea	Coptis chinensis
H0071	Bai Ye	柏叶	Chinese arborvitae twig	Platycladus orientalis
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0855	Chuan Bei Mu	川贝母	Fritillaria unibracteata	Fritillaria cirrhosa
H0650	Chai Hu	柴胡	Chinese thorowax	Bupleurum chinense
H0714	Yan Tai Chai Hu	烟台柴胡	Chinese thorowax	Bupleurum chinense
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0026	Jiang	姜	Soybean paste	Glycine max
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0424	Shan Zhi	山栀	Cape jasmine	Gardenia jasminoides
H1120	Guang Huo Xiang	广藿香	Patchouli	Pogostemon cablin
H0710	Yuan Hua Tiao	芫花条	stem of lilac daphne	Daphne genkwa
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max
H1253	Huang Qin Jin Gao Fen	黄芩浸膏粉	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H1030	Fang Feng	防风	Divaricate saposhnikovia	Saposhnikovia divaricata
H1106	Gua Lou Ren	瓜蒌仁	NA	Trichosanthes kirilowii
H0095	Gou Qi Zi	枸杞子	Chinese wolfberry fruit	Lycium chinense
H0100	Juan Bai	卷柏	Tamariskoid spikemoss	Selaginella tamariscina
H1183	Hong Dou	红豆	Hosie ormosia	Ormosia hosiei
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H0092	Ju Hua	菊花	Florists chrysanthemum flower	Chrysanthemum morifolium
H0072	Jing Jie	荆芥	Fineleaf schizonepeta	Schizonepeta tenuifolia
H0533	Teng Ku Shen	藤苦参	NA	Sophora flavescens
H0580	Tu Si Rou	菟丝肉	Dodder seed	Cuscuta australis
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0551	Cang Zhu	苍术	Swordlike atractylodes	Atractylodes lancea
H1133	Gui Jian Yu	鬼箭羽	Winged euonymus	Euonymus alatus
H1225	Huai Mi	槐米	NA	Sophora japonica
H0496	Shui Ze Lan	水泽兰	NA	Lycopus lucidus
H1128	Bai Jiang	败酱	Whiteflower patrinia	Patrinia villosa
H1007	Dou You	豆油	Soybean oil	Glycine max
H1254	Huang Qin Tan	黄芩炭	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0284	Nan She Teng	南蛇藤	Oriental bittersweet	Celastrus orbiculatus
H1017	Du Zhong Ye	杜仲叶	Eucommia leaf	Eucommia ulmoides
H0074	Jing Jie Tan	荆芥炭	NA	Schizonepetae herba
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0166	Long Kui	龙葵	Black nightshade	Solanum nigrum
H0530	Tao Ren Shuang	桃仁霜	Peach kernel	Prunus persica
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0237	Mei Gui Hua	玫瑰花	Rugose rose flower	Rosa rugosa
H0711	Yuan Hua Zhi Tiao	芫花枝条	stem of lilac daphne	Daphne genkwa
H0498	Si Ji Cai	四季菜	Ghostplant wormwood	Artemisia lactiflora
H1248	Huang Qi Gan Jin Gao	黄芪干浸膏	Membranous milkvetch	Astragalus membranaceus
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1108	Gua Lou Shi	栝蒌实	NA	Trichosanthes kirilowii
H1055	Bai Guo Ren	白果仁	ginkgo	Ginkgo biloba
H1218	Hua Sheng	花生	NA	Arachis hypogaea
H0247	Mi Meng Hua	密蒙花	Pale butterflybush	Buddleja officinalis
H0029	Jiang Huang Lian	姜黄连	Coptis deltoidea	Coptis chinensis
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0965	Deng Zhan Xi Xin	灯盏细辛	Shortscape fleabane	Erigeron breviscapus
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0664	Xiao Ji Tan	小蓟炭	Thistle	Cirsium arvense
H0638	Xiang Bei	象贝	Fritillaria	Fritillaria thunbergii
H0583	Tu Si Zi Teng	菟丝子藤	Dodder seed	Cuscuta australis
H0729	Ye Ju Hua	野菊花	Indian wild chrysanthemum flower	Chrysanthemum indicum
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H1105	Gua Lou Pi	瓜蒌皮	NA	Trichosanthes kirilowii
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0871	Chuan Duan	川断	Teasels	Dipsacus asper
H0568	Tu Er Cao	兔耳草	Lagotis	Lagotis brevituba
H0200	Ma Huang Gen	麻黄根	Chinese ephedra root	Ephedra sinica
H0758	Cheng Pi	橙皮	Bitter orange	Citrus aurantium
H0094	Gou Qi	枸杞	Chinese wolfberry fruit	Lycium chinense
H0713	Che Qian Cao	车前草	all-grass of rippleseed plantain	Plantago depressa
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0642	Xiang Jia Pi	香加皮	Chinese silkvine root-bark	Periploca sepium
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0613	Wu Yue Ai	五月艾	Artemisia	Artemisia princeps
H0750	Yin Xing Ye	银杏叶	Folium ginkgo	Ginkgo biloba
H0113	Ban Bian Lian	半边莲	Chinese lobelia	Lobelia chinensis
H0668	Xiao Ye Huang Yang	小叶黄杨	Small-leaved box	Buxus microphylla
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0005	Huo Xiang Ye	藿香叶	Patchouli	Pogostemon cablin
H1161	Hang Ju	杭菊	Chrysanthemum flower	Chrysanthemum morifolium
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H0859	Chuan Bei Mu Liu Jin Gao	川贝母流浸膏	Fritillaria unibracteata	Fritillaria cirrhosa
H0153	Ling Zhi(1)	灵芝	Lucid ganoderma	Ganoderma lucidum
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0692	Xue Ren Shen	血人参	NA	Lespedeza bicolor
H0665	Chai Hu Shao	柴胡梢	Chinese thorowax	Bupleurum chinense
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H0089	Ju Hong	橘红	NA	Citri exocarpium rubrum
H0219	Man Shan Hong	满山红	Dahurian rhododendron	Rhododendron dauricum
H0201	Ma Huang Jin Gao	麻黄浸膏	Chinese ephedra	Ephedra sinica
H1247	Huang Qi	黄芪	Membranous milkvetch	Astragalus membranaceus
H0957	Dang Gui Teng	当归藤	NA	Embelia parviflora
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0258	Mo Han Lian	墨旱莲	Yerbadetajo	Eclipta prostrata
H1010	Du Huo Xiang	杜藿香	Patchouli	Pogostemon cablin
H1015	Du Zhong	杜仲	Eucommia	Eucommia ulmoides
H0073	Jing Jie Sui	荆芥穗	NA	Schizonepetae spica
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0614	Wu Zhao Long	五爪龙	Cairo morningglory	Ipomoea cairica
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0974	Di Jin Cao	地锦草	Humifuse euphorbia	Euphorbia humifusa
H0821	Chu Ling Dan Cao	臭灵丹草	laggera pterodonta	Laggera pterodonta
H0315	Pu Gong Ying Jin Gao	蒲公英浸膏	Mongolian dandelion	Taraxacum mongolicum
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0727	Ye Gan Cao	野甘草	Sweet broomwort	Scoparia dulcis
H0663	Xiao Ji	小蓟	Setose thistle	Cirsium setosum
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0053	Jin Lian Hua	金莲花	Chinese globeflower	Trollius chinensis
H0872	Chuan Huang Lian	川黄连	rhizome of chinese goldthread	Coptis chinensis
H1141	Guo Gang Long Jin Gao	过岗龙浸膏	NA	Entada phaseoloides
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H1243	Huang Lian Xu	黄连须	Coptis deltoidea	Coptis chinensis
H0682	Xiong Huang Lian	雄黄连	Coptis deltoidea	Coptis chinensis
H1251	Huang Qin	黄芩	Root of Baikal skullcaap	Scutellaria baicalensis
H0696	Ya Jiao Ai	鸭脚艾	Ghostplant wormwood	Artemisia lactiflora
H0920	Da Ban Bian Lian	大半边莲	Asian lobelia	Lobelia chinensis
H0524	Tan Xiang	檀香	Sandalwood	Santalum album
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0197	Ma Huang	麻黄	Chinese ephedra	Ephedra sinica
H0546	Tian Shan Xue Lian Hua	天山雪莲花	NA	Saussurea involucrata
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0581	Tu Si Zi	菟丝子	Dodder seed	Cuscuta australis
H0130	Lei Gong Teng	雷公藤	Common threewingnut	Tripterygium wilfordii
H0572	Tu Huo Xiang	土藿香	Patchouli	Pogostemon cablin
H1250	Huang Qi Ti Qu Ye	黄芪提取液	Membranous milkvetch	Astragalus membranaceus
H1244	Huang Miao	黄苗	NA	Taraxacum mongolicum
H0819	Zhi Zi Jin Gao	栀子浸膏	Cape jasmine fruit	Gardenia jasminoides
H0886	Chuan Xin Lian	穿心莲	Common andrographis	Andrographis paniculata
H0826	Chu Mu Dan	臭牡丹	rose glorybower	Clerodendrum bungei
H0813	Zhi Shi	枳实	Seville orange young fruit	Citrus aurantium
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0889	Chuan Xin Lian Jin Gao	穿心莲浸膏	Common andrographis	Andrographis paniculata
H0529	Tao Ren	桃仁	Peach kernel	Prunus persica
H0214	Bei He Huan	北合欢	Albizia	Albizia julibrissin
H0785	Ze Xi Huang Lian	择细黄连	Coptis deltoidea	Coptis chinensis
H1249	Huang Qi Jin Gao	黄芪浸膏	Membranous milkvetch	Astragalus membranaceus
H0691	Xue Lian Hua	雪莲花	Snow lotus	Saussurea involucrata
H0659	Chai Hu Jin Gao	柴胡浸膏	Chinese thorowax	Bupleurum chinense
H0218	Man Jiu Jie	蔓九节	Creeping ninenode	Psychotria serpens
H0901	Chun Gen Teng	春根藤	Twig and leaf of creeping psychotria	Psychotria serpens
H1016	Du Zhong Tan	杜仲炭	Eucommia	Eucommia ulmoides
H1107	Gua Lou Ren Shuang	瓜蒌仁霜	NA	Trichosanthes kirilowii
H0457	Shi Er	石耳	Rock-Ears	Umbilicaria esculenta
H0164	Ban Zhi Lian	半枝莲	Barbed skullcap	Scutellaria barbata

Target Description

Related Compounds (Total: 7)

Related Herbs (Total: 223)