Compound Description
| ID: C0485 | Common name: Wogonin |
| IUPAC: 5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one | CAS: CAS:632-85-9 |
| Chembl ID: CHEMBL16171 | Pubchem ID: CID:5281703 |
| Formula: C16H12O5 | TCM-ID: TCMC2237 |
| Smiles: COC1=C(C=C(C2=C1OC(=CC2=O)C3=CC=CC=C3)O)O | |
| Alias:
Flavone, 5,7-dihydroxy-8-methoxy-;
Wogonin; 5,7-Dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one; 5,7-Dihydroxy-8-methoxyflavone |
Structure:
|
Related Targets (Total: 45)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
A | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
A | 3 Reference(s) |
| T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
A | 1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
A | 1 Reference(s) |
| T62P0D | Collagenase 3 | MMP13 |
P45452 |
A | 1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
A | 8 Reference(s) |
| T91OUC | Mucin-5AC | MUC5AC |
P98088 |
A | 1 Reference(s) |
| T31U13 | Cytochrome P450 2C19 | CYP2C19 |
P33261 |
A | 1 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
B | 1 Reference(s) |
| T54G8J | Protein kinase C delta type | PRKCD |
Q05655 |
B | 1 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
B | 3 Reference(s) |
| T80OJF | Interstitial collagenase | MMP1 |
P03956 |
B | 1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
B | 2 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
B | 3 Reference(s) |
| T75HMM | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 |
Q07820 |
B | 1 Reference(s) |
| T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
B | 1 Reference(s) |
| T32R5L | Cyclin-dependent kinase 9 | CDK9 |
P50750 |
B | 1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
C | 2 Reference(s) |
| T82ALJ | Glycogen synthase kinase-3 beta | GSK3B |
P49841 |
C | 2 Reference(s) |
| T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
C | 1 Reference(s) |
| T73HMK | Bcl-2-binding component 3, isoforms 1/2 | BBC3 |
Q9BXH1 |
C | 1 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
C | 1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
C | 1 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
C | 1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
C | 6 Reference(s) |
| T04MBA | Vascular endothelial growth factor receptor 2 | KDR |
P35968 |
C | 1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
C | 1 Reference(s) |
| T00CXT | Prostaglandin G/H synthase 1 | PTGS1 |
P23219 |
C | 1 Reference(s) |
| T04WT7 | Fibronectin | FN1 |
P02751 |
C | 1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
C | 1 Reference(s) |
| T17CZC | Tissue factor | F3 |
P13726 |
C | 1 Reference(s) |
| T67UWO | C-C motif chemokine 26 | CCL26 |
Q9Y258 |
C | 1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
C | 1 Reference(s) |
| T02IOG | Cyclin-dependent kinase inhibitor 1B | CDKN1B |
P46527 |
C | 1 Reference(s) |
| T67LQK | Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) | MAPK11 |
Q15759 |
C | 1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
C | 1 Reference(s) |
| T93PLN | Serine/threonine-protein kinase/endoribonuclease IRE1 | ERN1 |
O75460 |
C | 1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
C | 2 Reference(s) |
| T74D4Y | CASP8 and FADD-like apoptosis regulator | CFLAR |
O15519 |
C | 1 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
C | 1 Reference(s) |
| T50VJF | Osteopontin | SPP1 |
P10451 |
C | 1 Reference(s) |
| T53KRS | E3 ubiquitin-protein ligase NEDD4-like | NEDD4L |
Q96PU5 |
C | 1 Reference(s) |
| T10S5F | Cyclin-dependent kinase 4 | CDK4 |
P11802 |
C | 1 Reference(s) |
| T38G9K | TNF receptor-associated factor 2 | TRAF2 |
Q12933 |
C | 1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 47)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0531 | Tao Zhi | 桃枝 | Peach juvenile branch | Prunus persica |
| H1222 | Huai Hua | 槐花 | flower bud of japanese pagodatree | Sophora japonica |
| H1242 | Huang Lian Gan Jin Gao | 黄连干浸膏 | Coptis deltoidea | Coptis chinensis |
| H0665 | Chai Hu Shao | 柴胡梢 | Chinese thorowax | Bupleurum chinense |
| H0626 | Xi Nan Huang Qin | 西南黄芩 | Yunnan skullcap | Scutellaria amoena |
| H0889 | Chuan Xin Lian Jin Gao | 穿心莲浸膏 | Common andrographis | Andrographis paniculata |
| H1227 | Huai Zhi | 槐枝 | NA | Sophora japonica |
| H1247 | Huang Qi | 黄芪 | Membranous milkvetch | Astragalus membranaceus |
| H0818 | Zhi Zi | 栀子 | Cape jasmine fruit | Gardenia jasminoides |
| H1248 | Huang Qi Gan Jin Gao | 黄芪干浸膏 | Membranous milkvetch | Astragalus membranaceus |
| H0164 | Ban Zhi Lian | 半枝莲 | Barbed skullcap | Scutellaria barbata |
| H0887 | Chuan Xin Lian Gan Jin Gao | 穿心莲干浸膏 | Common andrographis | Andrographis paniculata |
| H1016 | Du Zhong Tan | 杜仲炭 | Eucommia | Eucommia ulmoides |
| H0270 | Mu Hu Die | 木蝴蝶 | Indian trumpetflower | Oroxylum indicum |
| H0424 | Shan Zhi | 山栀 | Cape jasmine | Gardenia jasminoides |
| H0529 | Tao Ren | 桃仁 | Peach kernel | Prunus persica |
| H0530 | Tao Ren Shuang | 桃仁霜 | Peach kernel | Prunus persica |
| H0029 | Jiang Huang Lian | 姜黄连 | Coptis deltoidea | Coptis chinensis |
| H1253 | Huang Qin Jin Gao Fen | 黄芩浸膏粉 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H0819 | Zhi Zi Jin Gao | 栀子浸膏 | Cape jasmine fruit | Gardenia jasminoides |
| H1017 | Du Zhong Ye | 杜仲叶 | Eucommia leaf | Eucommia ulmoides |
| H1250 | Huang Qi Ti Qu Ye | 黄芪提取液 | Membranous milkvetch | Astragalus membranaceus |
| H0744 | Yin Chai Hu | 银柴胡 | Lanceolate starwort | Stellaria dichotoma var. lanceolata |
| H0551 | Cang Zhu | 苍术 | Swordlike atractylodes | Atractylodes lancea |
| H0890 | Chuan Xin Lian Nong Suo Ye | 穿心莲浓缩液 | Common andrographis | Andrographis paniculata |
| H0760 | Yu Huang Lian | 萸黄连 | Coptis deltoidea | Coptis chinensis |
| H0891 | Chuan Xin Lian Ye | 穿心莲叶 | Powder of green chiretta leaves | Andrographis herba |
| H0659 | Chai Hu Jin Gao | 柴胡浸膏 | Chinese thorowax | Bupleurum chinense |
| H0682 | Xiong Huang Lian | 雄黄连 | Coptis deltoidea | Coptis chinensis |
| H1249 | Huang Qi Jin Gao | 黄芪浸膏 | Membranous milkvetch | Astragalus membranaceus |
| H0650 | Chai Hu | 柴胡 | Chinese thorowax | Bupleurum chinense |
| H0785 | Ze Xi Huang Lian | 择细黄连 | Coptis deltoidea | Coptis chinensis |
| H0886 | Chuan Xin Lian | 穿心莲 | Common andrographis | Andrographis paniculata |
| H0872 | Chuan Huang Lian | 川黄连 | rhizome of chinese goldthread | Coptis chinensis |
| H0527 | Tao | 桃 | Peach | Prunus persica |
| H1254 | Huang Qin Tan | 黄芩炭 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H1030 | Fang Feng | 防风 | Divaricate saposhnikovia | Saposhnikovia divaricata |
| H1243 | Huang Lian Xu | 黄连须 | Coptis deltoidea | Coptis chinensis |
| H0714 | Yan Tai Chai Hu | 烟台柴胡 | Chinese thorowax | Bupleurum chinense |
| H0310 | Pian Qin | 片芩 | Scutellaria amoena | Scutellaria baicalensis |
| H1225 | Huai Mi | 槐米 | NA | Sophora japonica |
| H1241 | Huang Lian | 黄连 | Coptis deltoidea | Coptis chinensis |
| H1224 | Huai Jiao | 槐角 | pod of japanese pagodatree | Sophora japonica |
| H1252 | Huang Qin Jin Gao | 黄芩浸膏 | Extract of root of Baikal skullcaap | Scutellaria baicalensis |
| H1015 | Du Zhong | 杜仲 | Eucommia | Eucommia ulmoides |
| H0082 | Jiu Huang Lian | 酒黄连 | Coptis deltoidea | Coptis chinensis |
| H1251 | Huang Qin | 黄芩 | Root of Baikal skullcaap | Scutellaria baicalensis |
Ckey description of the interaction between compound and target