HIT-result

Type	Detail
Target ID	T93PLN
Protein Name	Serine/threonine-protein kinase/endoribonuclease IRE1
Uniprot ID	O75460
Protein Name Alias	Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a
Gene ID	2081
Gene Symbol	ERN1
Gene Alias	IRE1
TTD	T01003: Clinical Trial target
Pfam	PF06479 ; PF00069
GO	0042802:identical protein binding 0046777:protein autophosphorylation 0034976:response to endoplasmic reticulum stress 0006402:mRNA catabolic process 0070301:cellular response to hydrogen peroxide 0007050:cell cycle arrest 1904707:positive regulation of vascular associated smooth muscle cell proliferation 0106310:protein serine kinase activity 0005789:endoplasmic reticulum membrane 0004674:protein serine/threonine kinase activity 1990630:IRE1-RACK1-PP2A complex 0036289:peptidyl-serine autophosphorylation 1900103:positive regulation of endoplasmic reticulum unfolded protein response 0106311:protein threonine kinase activity 0004521:endoribonuclease activity 0005637:nuclear inner membrane 0035924:cellular response to vascular endothelial growth factor stimulus 0005161:platelet-derived growth factor receptor binding 0098787:mRNA cleavage involved in mRNA processing 0001935:endothelial cell proliferation 0030176:integral component of endoplasmic reticulum membrane 0005737:cytoplasm 0036498:IRE1-mediated unfolded protein response 1990579:peptidyl-serine trans-autophosphorylation 0005524:ATP binding 0005783:endoplasmic reticulum 0000287:magnesium ion binding 0051879:Hsp90 protein binding 0019899:enzyme binding 0034620:cellular response to unfolded protein 1990604:IRE1-TRAF2-ASK1 complex 0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0007257:activation of JUN kinase activity 0051082:unfolded protein binding 0033120:positive regulation of RNA splicing 1990597:AIP1-IRE1 complex 0006379:mRNA cleavage 0006468:protein phosphorylation 0043531:ADP binding 0005739:mitochondrion 1990332:Ire1 complex 0042803:protein homodimerization activity 0071333:cellular response to glucose stimulus 0070054:mRNA splicing, via endonucleolytic cleavage and ligation 0030544:Hsp70 protein binding 1901142:insulin metabolic process 0016241:regulation of macroautophagy
PDB	5HGI ; 6W3C ; 4Z7H ; 2HZ6 ; 6HX1 ; 6W3E ; 4YZC ; 6W3A ; 6SHC ; 6W39 ; 4YZD ; 4Z7G ; 3P23 ; 6HV0 ; 4YZ9 ; 6W3K ; 4U6R ; 6W3B ; 6URC
Drugbank	DB12010 ; DB07382
KEGG	hsa:2081

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0530	Tao Ren Shuang	桃仁霜	Peach kernel	Prunus persica
H0785	Ze Xi Huang Lian	择细黄连	Coptis deltoidea	Coptis chinensis
H1225	Huai Mi	槐米	NA	Sophora japonica
H1016	Du Zhong Tan	杜仲炭	Eucommia	Eucommia ulmoides
H0890	Chuan Xin Lian Nong Suo Ye	穿心莲浓缩液	Common andrographis	Andrographis paniculata
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H1250	Huang Qi Ti Qu Ye	黄芪提取液	Membranous milkvetch	Astragalus membranaceus
H0714	Yan Tai Chai Hu	烟台柴胡	Chinese thorowax	Bupleurum chinense
H0029	Jiang Huang Lian	姜黄连	Coptis deltoidea	Coptis chinensis
H1015	Du Zhong	杜仲	Eucommia	Eucommia ulmoides
H0872	Chuan Huang Lian	川黄连	rhizome of chinese goldthread	Coptis chinensis
H1254	Huang Qin Tan	黄芩炭	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0887	Chuan Xin Lian Gan Jin Gao	穿心莲干浸膏	Common andrographis	Andrographis paniculata
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0424	Shan Zhi	山栀	Cape jasmine	Gardenia jasminoides
H0744	Yin Chai Hu	银柴胡	Lanceolate starwort	Stellaria dichotoma var. lanceolata
H0650	Chai Hu	柴胡	Chinese thorowax	Bupleurum chinense
H0659	Chai Hu Jin Gao	柴胡浸膏	Chinese thorowax	Bupleurum chinense
H0082	Jiu Huang Lian	酒黄连	Coptis deltoidea	Coptis chinensis
H0891	Chuan Xin Lian Ye	穿心莲叶	Powder of green chiretta leaves	Andrographis herba
H0529	Tao Ren	桃仁	Peach kernel	Prunus persica
H1017	Du Zhong Ye	杜仲叶	Eucommia leaf	Eucommia ulmoides
H0682	Xiong Huang Lian	雄黄连	Coptis deltoidea	Coptis chinensis
H1247	Huang Qi	黄芪	Membranous milkvetch	Astragalus membranaceus
H1243	Huang Lian Xu	黄连须	Coptis deltoidea	Coptis chinensis
H0886	Chuan Xin Lian	穿心莲	Common andrographis	Andrographis paniculata
H0819	Zhi Zi Jin Gao	栀子浸膏	Cape jasmine fruit	Gardenia jasminoides
H0531	Tao Zhi	桃枝	Peach juvenile branch	Prunus persica
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H1251	Huang Qin	黄芩	Root of Baikal skullcaap	Scutellaria baicalensis
H1253	Huang Qin Jin Gao Fen	黄芩浸膏粉	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0310	Pian Qin	片芩	Scutellaria amoena	Scutellaria baicalensis
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H0818	Zhi Zi	栀子	Cape jasmine fruit	Gardenia jasminoides
H0665	Chai Hu Shao	柴胡梢	Chinese thorowax	Bupleurum chinense
H0527	Tao	桃	Peach	Prunus persica
H0551	Cang Zhu	苍术	Swordlike atractylodes	Atractylodes lancea
H0889	Chuan Xin Lian Jin Gao	穿心莲浸膏	Common andrographis	Andrographis paniculata
H0164	Ban Zhi Lian	半枝莲	Barbed skullcap	Scutellaria barbata
H1030	Fang Feng	防风	Divaricate saposhnikovia	Saposhnikovia divaricata
H1249	Huang Qi Jin Gao	黄芪浸膏	Membranous milkvetch	Astragalus membranaceus
H1248	Huang Qi Gan Jin Gao	黄芪干浸膏	Membranous milkvetch	Astragalus membranaceus
H1242	Huang Lian Gan Jin Gao	黄连干浸膏	Coptis deltoidea	Coptis chinensis
H1252	Huang Qin Jin Gao	黄芩浸膏	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H1241	Huang Lian	黄连	Coptis deltoidea	Coptis chinensis
H0760	Yu Huang Lian	萸黄连	Coptis deltoidea	Coptis chinensis

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 47)