Herb Description
| Herb ID: H0668 | Chinese Character: 小叶黄杨 |
| English Name: Small-leaved box | Latin Name: Buxus microphylla |
| Chinese Pin Yin : Xiao Ye Huang Yang | TCM-ID: TCMH2306 |
| Therapeutic Function in Chinese : NA | Therapeutic Function in English: NA |
| Herb Function: NA | |
Related Targets (Total: 156)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T51IKV | DNA topoisomerase 2-alpha | TOP2A |
P11388 |
1 Reference(s) |
| T87DEX | Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase | XDH |
P47989 |
4 Reference(s) |
| T32R5L | Cyclin-dependent kinase 9 | CDK9 |
P50750 |
2 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
| T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
2 Reference(s) |
| T62UOD | Serine/threonine-protein kinase VRK1 | VRK1 |
Q99986 |
1 Reference(s) |
| T47H3O | Heat shock protein HSP 90-alpha | HSP90AA1 |
P07900 |
1 Reference(s) |
| T60B3R | Glutathione S-transferase kappa 1 | GSTK1 |
Q9Y2Q3 |
1 Reference(s) |
| T67CB6 | Transcriptional regulator ERG | ERG |
P11308 |
1 Reference(s) |
| T39M6J | ATP-binding cassette sub-family C member 2 | ABCC2 |
Q92887 |
1 Reference(s) |
| T97FEF | Broad substrate specificity ATP-binding cassette transporter ABCG2 | ABCG2 |
Q9UNQ0 |
1 Reference(s) |
| T11NOZ | NA | MIR132 |
NA |
1 Reference(s) |
| T71BDH | Mitogen-activated protein kinase 14 | MAPK14 |
Q16539 |
3 Reference(s) |
| T68DAN | Histone deacetylase 9 | HDAC9 |
Q9UKV0 |
1 Reference(s) |
| T74QXI | Serine/threonine-protein kinase mTOR | MTOR |
P42345 |
1 Reference(s) |
| T91AIW | Receptor-type tyrosine-protein kinase FLT3 | FLT3 |
P36888 |
1 Reference(s) |
| T25M2J | Anoctamin-1 | ANO1 |
Q5XXA6 |
1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
4 Reference(s) |
| T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
1 Reference(s) |
| T29B10 | Interleukin-17A | IL17A |
Q16552 |
1 Reference(s) |
| T38O11 | Cyclin-G-associated kinase | GAK |
O14976 |
1 Reference(s) |
| T86CQC | Glutamate receptor ionotropic, NMDA 1 | GRIN1 |
Q05586 |
1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
7 Reference(s) |
| T58XLK | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 |
P18031 |
1 Reference(s) |
| T82ALJ | Glycogen synthase kinase-3 beta | GSK3B |
P49841 |
4 Reference(s) |
| T88LSZ | Aromatase | CYP19A1 |
P11511 |
1 Reference(s) |
| T83SXS | 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 | HSD17B7 |
P56937 |
1 Reference(s) |
| T16UZ4 | Dipeptidyl peptidase 4 | DPP4 |
P27487 |
1 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
4 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
5 Reference(s) |
| T10ICM | Oxidized low-density lipoprotein receptor 1 | OLR1 |
P78380 |
1 Reference(s) |
| T48DAP | 40S ribosomal protein S9 | RPS9 |
P46781 |
1 Reference(s) |
| T42D4V | Histone deacetylase 1 | HDAC1 |
Q13547 |
1 Reference(s) |
| T64X48 | C-X-C chemokine receptor type 4 | CXCR4 |
P61073 |
1 Reference(s) |
| T86MX7 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | CD38 |
P28907 |
1 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
2 Reference(s) |
| T42PUG | Solute carrier family 2, facilitated glucose transporter member 1 | SLC2A1 |
P11166 |
3 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
3 Reference(s) |
| T68HNO | Glutathione S-transferase omega-1 | GSTO1 |
P78417 |
1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
2 Reference(s) |
| T40DIM | Corticosteroid 11-beta-dehydrogenase isozyme 1 | HSD11B1 |
P28845 |
1 Reference(s) |
| T87AXU | ADP/ATP translocase 2 | SLC25A5 |
P05141 |
2 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
2 Reference(s) |
| T05RAA | Inhibitor of nuclear factor kappa-B kinase subunit alpha | CHUK |
O15111 |
1 Reference(s) |
| T55IBP | Zinc finger protein SNAI1 | SNAI1 |
O95863 |
1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
6 Reference(s) |
| T62USB | Tumor necrosis factor receptor superfamily member 10A | TNFRSF10A |
O00220 |
1 Reference(s) |
| T32PI2 | Programmed cell death 1 ligand 1 | CD274 |
Q9NZQ7 |
1 Reference(s) |
| T40XWM | Proto-oncogene tyrosine-protein kinase ROS | ROS1 |
P08922 |
1 Reference(s) |
| T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
1 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
2 Reference(s) |
| T99XQ3 | DNA topoisomerase 1 | TOP1 |
P11387 |
1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
1 Reference(s) |
| T14LSK | E3 ubiquitin-protein ligase XIAP | XIAP |
P98170 |
2 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
5 Reference(s) |
| T13KGH | Tyrosinase | TYR |
P14679 |
1 Reference(s) |
| T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
2 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
5 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
9 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
2 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
10 Reference(s) |
| T47HTN | Prostaglandin E synthase | PTGES |
O14684 |
1 Reference(s) |
| T38K2W | Receptor tyrosine-protein kinase erbB-2 | ERBB2 |
P04626 |
1 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
8 Reference(s) |
| T10S5F | Cyclin-dependent kinase 4 | CDK4 |
P11802 |
2 Reference(s) |
| T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
2 Reference(s) |
| T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
5 Reference(s) |
| T24LXT | G2/mitotic-specific cyclin-B1 | CCNB1 |
P14635 |
4 Reference(s) |
| T75HMM | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 |
Q07820 |
2 Reference(s) |
| T74I49 | Bcl-2-like protein 1 | BCL2L1 |
Q07817 |
3 Reference(s) |
| T06PVX | E3 ubiquitin-protein ligase Mdm2 | MDM2 |
Q00987 |
2 Reference(s) |
| T92AMR | Hepatocyte growth factor receptor | MET |
P08581 |
1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
5 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
9 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
3 Reference(s) |
| T69NG6 | Interleukin-10 | IL10 |
P22301 |
2 Reference(s) |
| T37VLU | Interferon gamma | IFNG |
P01579 |
2 Reference(s) |
| T88B8X | Insulin receptor | INSR |
P06213 |
2 Reference(s) |
| T68SE0 | Solute carrier family 2, facilitated glucose transporter member 4 | SLC2A4 |
P14672 |
2 Reference(s) |
| T80OJF | Interstitial collagenase | MMP1 |
P03956 |
2 Reference(s) |
| T60GGR | Serine/threonine-protein kinase TBK1 | TBK1 |
Q9UHD2 |
1 Reference(s) |
| T29MD1 | Mitogen-activated protein kinase 8 | MAPK8 |
P45983 |
1 Reference(s) |
| T01E7W | Aurora kinase B | AURKB |
Q96GD4 |
1 Reference(s) |
| T77M4W | Adenosine receptor A2a | ADORA2A |
P29274 |
1 Reference(s) |
| T62Y4H | Protein kinase C epsilon type | PRKCE |
Q02156 |
1 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
2 Reference(s) |
| T35LKG | Adenosine receptor A1 | ADORA1 |
P30542 |
1 Reference(s) |
| T45G32 | Proto-oncogene tyrosine-protein kinase Src | SRC |
P12931 |
2 Reference(s) |
| T74D4Y | CASP8 and FADD-like apoptosis regulator | CFLAR |
O15519 |
1 Reference(s) |
| T95K8Q | Intestinal-type alkaline phosphatase | ALPI |
P09923 |
1 Reference(s) |
| T20JZ2 | Androgen receptor | AR |
P10275 |
1 Reference(s) |
| T98FWP | NF-kappa-B essential modulator | IKBKG |
Q9Y6K9 |
1 Reference(s) |
| T94VM4 | 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) | HSD17B2 |
P37059 |
1 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
4 Reference(s) |
| T42XY2 | Insulin-like growth factor 1 receptor | IGF1R |
P08069 |
2 Reference(s) |
| T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
3 Reference(s) |
| T54VQA | Cyclin-dependent kinase inhibitor 2A | CDKN2A |
P42771 |
2 Reference(s) |
| T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
2 Reference(s) |
| T86UXL | Cyclin-A2 | CCNA2 |
P20248 |
1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
3 Reference(s) |
| T35QZO | Cytochrome c | CYCS |
P99999 |
1 Reference(s) |
| T91T8I | Glucose-6-phosphatase catalytic subunit 1 | G6PC1 |
P35575 |
1 Reference(s) |
| T06IYF | Adenomatous polyposis coli protein | APC |
P25054 |
1 Reference(s) |
| T50GQE | Interleukin-13 | IL13 |
P35225 |
1 Reference(s) |
| T22IMH | Cyclin-dependent kinase 6 | CDK6 |
Q00534 |
1 Reference(s) |
| T02WMA | Ornithine decarboxylase | ODC1 |
P11926 |
1 Reference(s) |
| T84P70 | Urokinase-type plasminogen activator | PLAU |
P00749 |
2 Reference(s) |
| T36SOV | Plasminogen activator inhibitor 1 | SERPINE1 |
P05121 |
1 Reference(s) |
| T62QDU | Alpha- and gamma-adaptin-binding protein p34 | AAGAB |
Q6PD74 |
1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
1 Reference(s) |
| T91OUC | Mucin-5AC | MUC5AC |
P98088 |
1 Reference(s) |
| T21S10 | Heterogeneous nuclear ribonucleoproteins A2/B1 | HNRNPA2B1 |
P22626 |
1 Reference(s) |
| T46K2X | Heat shock 70 kDa protein 4 | HSPA4 |
P34932 |
1 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
1 Reference(s) |
| T68AKE | Zinc fingers and homeoboxes protein 2 | ZHX2 |
Q9Y6X8 |
1 Reference(s) |
| T73LPO | Poly [ADP-ribose] polymerase 1 | PARP1 |
P09874 |
1 Reference(s) |
| T10K5R | NA | MIR203A |
NA |
1 Reference(s) |
| T66WWM | Claudin-2 | CLDN2 |
P57739 |
2 Reference(s) |
| T78O6C | Mothers against decapentaplegic homolog 3 | SMAD3 |
P84022 |
1 Reference(s) |
| T92HNO | High mobility group protein B1 | HMGB1 |
P09429 |
1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
2 Reference(s) |
| T78IOY | Telomerase reverse transcriptase | TERT |
O14746 |
1 Reference(s) |
| T41BXR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | SIRT3 |
Q9NTG7 |
1 Reference(s) |
| T41DXP | Pleiotrophin | PTN |
P21246 |
1 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
1 Reference(s) |
| T62RLH | NA | MIR384 |
NA |
1 Reference(s) |
| T87O4D | Mitogen-activated protein kinase 7 | MAPK7 |
Q13164 |
1 Reference(s) |
| T04LY5 | Creatine kinase B-type | CKB |
P12277 |
1 Reference(s) |
| T67JR8 | Heat shock factor protein 1 | HSF1 |
Q00613 |
1 Reference(s) |
| T04TWI | CD40 ligand | CD40LG |
P29965 |
1 Reference(s) |
| T41TXS | Retinoblastoma-associated protein | RB1 |
P06400 |
1 Reference(s) |
| T92UBJ | Acetyl-CoA carboxylase 1 | ACACA |
Q13085 |
1 Reference(s) |
| T87WMV | Sodium/potassium-transporting ATPase subunit gamma | FXYD2 |
P54710 |
1 Reference(s) |
| T00KKS | Sodium/iodide cotransporter | SLC5A5 |
Q92911 |
1 Reference(s) |
| T38BR0 | G1/S-specific cyclin-D2 | CCND2 |
P30279 |
2 Reference(s) |
| T78ILO | Stearoyl-CoA desaturase | SCD |
O00767 |
1 Reference(s) |
| T96G89 | Fatty acid-binding protein, adipocyte | FABP4 |
P15090 |
1 Reference(s) |
| T90ORW | Bcl2-associated agonist of cell death | BAD |
Q92934 |
1 Reference(s) |
| T89L4V | Insulin | INS |
P01308 |
1 Reference(s) |
| T04UTZ | G1/S-specific cyclin-E1 | CCNE1 |
P24864 |
1 Reference(s) |
| T22I6G | Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6) | CDKN2C |
P42773 |
1 Reference(s) |
| T25S1M | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) (Fragment) | p27 kip1 |
O43806 |
1 Reference(s) |
| T05PKX | Steroid 17-alpha-hydroxylase/17,20 lyase | CYP17A1 |
P05093 |
1 Reference(s) |
| T74ETU | Steroid 21-hydroxylase | CYP21A2 |
P08686 |
1 Reference(s) |
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
1 Reference(s) |
| T65S3S | Tyrosine-protein kinase JAK2 | JAK2 |
O60674 |
1 Reference(s) |
| T27LTU | C5a anaphylatoxin chemotactic receptor 1 | C5AR1 |
P21730 |
1 Reference(s) |
| T00QMT | NA | MIR15B |
NA |
1 Reference(s) |
| T06ADX | Tyrosine-protein kinase receptor UFO | AXL |
P30530 |
1 Reference(s) |
| T30L86 | Tumor necrosis factor receptor superfamily member 10B | TNFRSF10B |
O14763 |
1 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
1 Reference(s) |
| T52RGZ | Growth/differentiation factor 15 | GDF15 |
Q99988 |
1 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
1 Reference(s) |
| T40JZG | GPI-anchor transamidase | PIGK |
Q92643 |
1 Reference(s) |
| T20TPU | Histone acetyltransferase KAT2B | KAT2B |
Q92831 |
1 Reference(s) |
| T57HGP | Tumor necrosis factor receptor superfamily member 6 | FAS |
P25445 |
1 Reference(s) |
key description of the interaction between compound and target