Target Description

Type Detail
Target ID T52RGZ
Protein Name Growth/differentiation factor 15
Uniprot ID Q99988
Protein Name Alias GDF-15;  Macrophage inhibitory cytokine 1;  MIC-1;  NSAID-activated gene 1 protein;  NAG-1;  NSAID-regulated gene 1 protein;  NRG-1;  Placental TGF-beta;  Placental bone morphogenetic protein;  Prostate differentiation factor
Gene ID 9518
Gene Symbol GDF15
Gene Alias MIC1;  PDF;  PLAB;  PTGFB
TTD T33245: Research target
Pfam PF00019
GO
0005634:nucleus

0030509:BMP signaling pathway

0010862:positive regulation of pathway-restricted SMAD protein phosphorylation

0043410:positive regulation of MAPK cascade

0070062:extracellular exosome

0007179:transforming growth factor beta receptor signaling pathway

0060400:negative regulation of growth hormone receptor signaling pathway

0002023:reduction of food intake in response to dietary excess

0040015:negative regulation of multicellular organism growth

0051897:positive regulation of protein kinase B signaling

0000187:activation of MAPK activity

0070700:BMP receptor binding

0005615:extracellular space

0008083:growth factor activity

0005125:cytokine activity

0035860:glial cell-derived neurotrophic factor receptor signaling pathway

0007267:cell-cell signaling

0060395:SMAD protein signal transduction

1901741:positive regulation of myoblast fusion

0005576:extracellular region

0005794:Golgi apparatus

0042803:protein homodimerization activity

0005737:cytoplasm

0007165:signal transduction

PDB 6Q2J ; 5VZ4 ; 5VT2 ; 5VZ3
Drugbank NA
KEGG hsa:9518

Related Compounds  (Total: 2)

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C0213
Name: Metformin
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C0914
Name: Apigenin


Related Herbs  (Total: 159)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1112 Gua Lou Ren(1)栝楼仁 NATrichosanthes kirilowii
H0193 Ma Bian Cao马鞭草 European verbenaVerbena officinalis
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0816 Chu Ling Dan臭灵丹 laggera pterodontaLaggera pterodonta
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H1219 Hua Sheng Mi花生米 NAArachis hypogaea
H0918 Cu Yuan Hua醋芫花 Lilac daphneDaphne genkwa
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0142 Liang Jiang良姜 NAAlpinia officinarum
H1111 Gua Lou Gen栝楼根 NATrichosanthes kirilowii
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H0975 Di Mian Cao地绵草 NAEuphorbia humifusa
H1140 Guo Gang Long过岗龙 NAEntada phaseoloides
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H0887 Chuan Xin Lian Gan Jin Gao穿心莲干浸膏 Common andrographisAndrographis paniculata
H0707 Yuan Hua芫花 Lilac daphneDaphne genkwa
H0690 Xue Lian雪莲 Snow lotusSaussurea involucrata
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0539 Tian Hua Fen天花粉 Mongolian snakegourd rootTrichosanthes kirilowii
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H0300 Nv Zhen Zi女贞子 Glossy privet fruitLigustrum lucidum
H1090 Gao Ben藁本 Chinese ligusticumLigusticum sinense
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H1021 E Da Xia莪大夏 NAOxytropis falcata
H0185 Luo Shi Teng络石藤 Chinese star jasmineTrachelospermum jasminoides
H0708 Yuan Hua Gen芫花根 Lilac daphne rootDaphne genkwa
H0183 Luo Hua Sheng Zhi Ye落花生枝叶 Peanut branch-leafArachis hypogaea
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H1138 Bai Jiang Cao败酱草 All - grass of dahurian patriniaThlaspi arvense
H0279 Nan Gua南瓜 CushawCucurbita moschata
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H0204 Ma Ren麻仁 NACannabis sativa
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0802 Zhi Geng枳梗 NACitrus aurantium
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0890 Chuan Xin Lian Nong Suo Ye穿心莲浓缩液 Common andrographisAndrographis paniculata
H0152 Ling Zhi Jin Gao灵芝浸膏 NAGanoderma lucidum
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H0805 Zhi Ke Gan Jin Gao枳壳干浸膏 Seville ora nge unripe fruitCitrus aurantium
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H0071 Bai Ye柏叶 Chinese arborvitae twigPlatycladus orientalis
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0855 Chuan Bei Mu川贝母 Fritillaria unibracteataFritillaria cirrhosa
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0026 Jiang Soybean pasteGlycine max
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0710 Yuan Hua Tiao芫花条 stem of lilac daphneDaphne genkwa
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H1106 Gua Lou Ren瓜蒌仁 NATrichosanthes kirilowii
H0095 Gou Qi Zi枸杞子 Chinese wolfberry fruitLycium chinense
H0100 Juan Bai卷柏 Tamariskoid spikemossSelaginella tamariscina
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H0072 Jing Jie荆芥 Fineleaf schizonepetaSchizonepeta tenuifolia
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0580 Tu Si Rou菟丝肉 Dodder seedCuscuta australis
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1133 Gui Jian Yu鬼箭羽 Winged euonymusEuonymus alatus
H1007 Dou You豆油 Soybean oilGlycine max
H0496 Shui Ze Lan水泽兰 NALycopus lucidus
H1128 Bai Jiang败酱 Whiteflower patriniaPatrinia villosa
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H0074 Jing Jie Tan荆芥炭 NASchizonepetae herba
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0237 Mei Gui Hua玫瑰花 Rugose rose flowerRosa rugosa
H0711 Yuan Hua Zhi Tiao芫花枝条 stem of lilac daphneDaphne genkwa
H0498 Si Ji Cai四季菜 Ghostplant wormwoodArtemisia lactiflora
H1248 Huang Qi Gan Jin Gao黄芪干浸膏 Membranous milkvetchAstragalus membranaceus
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1108 Gua Lou Shi栝蒌实 NATrichosanthes kirilowii
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H1218 Hua Sheng花生 NAArachis hypogaea
H0247 Mi Meng Hua密蒙花 Pale butterflybushBuddleja officinalis
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0664 Xiao Ji Tan小蓟炭 ThistleCirsium arvense
H0638 Xiang Bei象贝 FritillariaFritillaria thunbergii
H0583 Tu Si Zi Teng菟丝子藤 Dodder seedCuscuta australis
H0729 Ye Ju Hua野菊花 Indian wild chrysanthemum flowerChrysanthemum indicum
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H1105 Gua Lou Pi瓜蒌皮 NATrichosanthes kirilowii
H0871 Chuan Duan川断 TeaselsDipsacus asper
H0568 Tu Er Cao兔耳草 LagotisLagotis brevituba
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H0094 Gou Qi枸杞 Chinese wolfberry fruitLycium chinense
H0713 Che Qian Cao车前草 all-grass of rippleseed plantainPlantago depressa
H0642 Xiang Jia Pi香加皮 Chinese silkvine root-barkPeriploca sepium
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0613 Wu Yue Ai五月艾 ArtemisiaArtemisia princeps
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H0113 Ban Bian Lian半边莲 Chinese lobeliaLobelia chinensis
H0668 Xiao Ye Huang Yang小叶黄杨 Small-leaved boxBuxus microphylla
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H0859 Chuan Bei Mu Liu Jin Gao川贝母流浸膏 Fritillaria unibracteataFritillaria cirrhosa
H0153 Ling Zhi(1)灵芝 Lucid ganodermaGanoderma lucidum
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0692 Xue Ren Shen血人参 NALespedeza bicolor
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H0089 Ju Hong橘红 NACitri exocarpium rubrum
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H1247 Huang Qi黄芪 Membranous milkvetchAstragalus membranaceus
H0957 Dang Gui Teng当归藤 NAEmbelia parviflora
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H0073 Jing Jie Sui荆芥穗 NASchizonepetae spica
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0974 Di Jin Cao地锦草 Humifuse euphorbiaEuphorbia humifusa
H0821 Chu Ling Dan Cao臭灵丹草 laggera pterodontaLaggera pterodonta
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0727 Ye Gan Cao野甘草 Sweet broomwortScoparia dulcis
H0663 Xiao Ji小蓟 Setose thistleCirsium setosum
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H1141 Guo Gang Long Jin Gao过岗龙浸膏 NAEntada phaseoloides
H1104 Gua Lou瓜蒌 NATrichosanthes kirilowii
H0370 Ru Xiang乳香 OlibanumBoswellia carterii
H0696 Ya Jiao Ai鸭脚艾 Ghostplant wormwoodArtemisia lactiflora
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H0920 Da Ban Bian Lian大半边莲 Asian lobeliaLobelia chinensis
H0524 Tan Xiang檀香 SandalwoodSantalum album
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H0546 Tian Shan Xue Lian Hua天山雪莲花 NASaussurea involucrata
H0581 Tu Si Zi菟丝子 Dodder seedCuscuta australis
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H1250 Huang Qi Ti Qu Ye黄芪提取液 Membranous milkvetchAstragalus membranaceus
H0826 Chu Mu Dan臭牡丹 rose glorybowerClerodendrum bungei
H0886 Chuan Xin Lian穿心莲 Common andrographisAndrographis paniculata
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium
H0889 Chuan Xin Lian Jin Gao穿心莲浸膏 Common andrographisAndrographis paniculata
H0214 Bei He Huan北合欢 AlbiziaAlbizia julibrissin
H1249 Huang Qi Jin Gao黄芪浸膏 Membranous milkvetchAstragalus membranaceus
H0691 Xue Lian Hua雪莲花 Snow lotusSaussurea involucrata
H0218 Man Jiu Jie蔓九节 Creeping ninenodePsychotria serpens
H0901 Chun Gen Teng春根藤 Twig and leaf of creeping psychotriaPsychotria serpens
H1107 Gua Lou Ren Shuang瓜蒌仁霜 NATrichosanthes kirilowii
H0457 Shi Er石耳 Rock-EarsUmbilicaria esculenta
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata