Herb Description

Herb ID:   H1108 Chinese Character:   栝蒌实
English Name:  NA Latin Name:  Trichosanthes kirilowii
Chinese Pin Yin :  Gua Lou Shi TCM-ID:  TCMH709
Therapeutic Function in Chinese :  NA Therapeutic Function in English:  NA
Herb Function:  NA

Related Targets  (Total: 224)

Target idProtein NameGene SymbolUniprot IDNo.of Literature Evidence
T12T4H Brain-derived neurotrophic factorBDNF P23560
2 Reference(s)
T58XLK Tyrosine-protein phosphatase non-receptor type 1PTPN1 P18031
2 Reference(s)
T77PFO Histone deacetylase 6HDAC6 Q9UBN7
1 Reference(s)
T22NX4 Toll-like receptor 2TLR2 O60603
1 Reference(s)
T76QBQ CREB-regulated transcription coactivator 2CRTC2 Q53ET0
1 Reference(s)
T49ORJ Peroxisome proliferator-activated receptor alphaPPARA Q07869
2 Reference(s)
T37G49 Platelet-activating factor acetylhydrolasePLA2G7 Q13093
1 Reference(s)
T13KGH TyrosinaseTYR P14679
2 Reference(s)
T31MUM 5,6-dihydroxyindole-2-carboxylic acid oxidaseTYRP1 P17643
1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
4 Reference(s)
T70U24 Sigma non-opioid intracellular receptor 1SIGMAR1 Q99720
1 Reference(s)
T23P74 Caspase-9CASP9 P55211
5 Reference(s)
T85U8U Caspase-3CASP3 P42574
14 Reference(s)
T50SJ8 5'-AMP-activated protein kinase catalytic subunit alpha-2PRKAA2 P54646
1 Reference(s)
T88LSZ AromataseCYP19A1 P11511
1 Reference(s)
T83SXS 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7HSD17B7 P56937
1 Reference(s)
T16UZ4 Dipeptidyl peptidase 4DPP4 P27487
1 Reference(s)
T50V79 Interleukin-4IL4 P05112
4 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
5 Reference(s)
T10ICM Oxidized low-density lipoprotein receptor 1OLR1 P78380
1 Reference(s)
T48DAP 40S ribosomal protein S9RPS9 P46781
1 Reference(s)
T82ALJ Glycogen synthase kinase-3 betaGSK3B P49841
3 Reference(s)
T42D4V Histone deacetylase 1HDAC1 Q13547
1 Reference(s)
T64X48 C-X-C chemokine receptor type 4CXCR4 P61073
1 Reference(s)
T86MX7 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1CD38 P28907
1 Reference(s)
T32R5L Cyclin-dependent kinase 9CDK9 P50750
2 Reference(s)
T11BI7 Toll-like receptor 4TLR4 O00206
2 Reference(s)
T42PUG Solute carrier family 2, facilitated glucose transporter member 1SLC2A1 P11166
3 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
5 Reference(s)
T71BDH Mitogen-activated protein kinase 14MAPK14 Q16539
4 Reference(s)
T68HNO Glutathione S-transferase omega-1GSTO1 P78417
2 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
3 Reference(s)
T40DIM Corticosteroid 11-beta-dehydrogenase isozyme 1HSD11B1 P28845
1 Reference(s)
T87AXU ADP/ATP translocase 2SLC25A5 P05141
2 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
3 Reference(s)
T05RAA Inhibitor of nuclear factor kappa-B kinase subunit alphaCHUK O15111
1 Reference(s)
T55IBP Zinc finger protein SNAI1SNAI1 O95863
1 Reference(s)
T33OPP Interleukin-6IL6 P05231
9 Reference(s)
T62USB Tumor necrosis factor receptor superfamily member 10ATNFRSF10A O00220
1 Reference(s)
T32PI2 Programmed cell death 1 ligand 1CD274 Q9NZQ7
1 Reference(s)
T40XWM Proto-oncogene tyrosine-protein kinase ROSROS1 P08922
1 Reference(s)
T51IKV DNA topoisomerase 2-alphaTOP2A P11388
1 Reference(s)
T87DEX Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenaseXDH P47989
4 Reference(s)
T74JJN Fatty acid synthaseFASN P49327
2 Reference(s)
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
2 Reference(s)
T62UOD Serine/threonine-protein kinase VRK1VRK1 Q99986
1 Reference(s)
T47H3O Heat shock protein HSP 90-alphaHSP90AA1 P07900
1 Reference(s)
T60B3R Glutathione S-transferase kappa 1GSTK1 Q9Y2Q3
1 Reference(s)
T67CB6 Transcriptional regulator ERGERG P11308
1 Reference(s)
T39M6J ATP-binding cassette sub-family C member 2ABCC2 Q92887
1 Reference(s)
T97FEF Broad substrate specificity ATP-binding cassette transporter ABCG2ABCG2 Q9UNQ0
1 Reference(s)
T11NOZ NAMIR132 NA
1 Reference(s)
T68DAN Histone deacetylase 9HDAC9 Q9UKV0
1 Reference(s)
T74QXI Serine/threonine-protein kinase mTORMTOR P42345
2 Reference(s)
T91AIW Receptor-type tyrosine-protein kinase FLT3FLT3 P36888
1 Reference(s)
T25M2J Anoctamin-1ANO1 Q5XXA6
1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
9 Reference(s)
T21DZX Amine oxidase [flavin-containing] AMAOA P21397
1 Reference(s)
T29B10 Interleukin-17AIL17A Q16552
1 Reference(s)
T38O11 Cyclin-G-associated kinaseGAK O14976
1 Reference(s)
T69XVX Cytochrome P450 1B1CYP1B1 Q16678
2 Reference(s)
T92AMR Hepatocyte growth factor receptorMET P08581
2 Reference(s)
T04MBA Vascular endothelial growth factor receptor 2KDR P35968
1 Reference(s)
T63BQU Cytochrome P450 1A1CYP1A1 P04798
1 Reference(s)
T30VNV MyeloperoxidaseMPO P05164
1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
9 Reference(s)
T83DDX Endothelial protein C receptorPROCR Q9UNN8
1 Reference(s)
T06VX0 MAP/microtubule affinity-regulating kinase 4MARK4 Q96L34
1 Reference(s)
T24C0P Bile acid receptorNR1H4 Q96RI1
1 Reference(s)
T77TY2 Protein disulfide-isomeraseP4HB P07237
1 Reference(s)
T20RA0 Adenosine deaminaseADA P00813
1 Reference(s)
T93SFQ NAD-dependent protein deacetylase sirtuin-1SIRT1 Q96EB6
1 Reference(s)
T43GWF Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1PPIP5K1 Q6PFW1
1 Reference(s)
T31ZFD Aldehyde oxidaseAOX1 Q06278
1 Reference(s)
T13WH4 Interferon-induced, double-stranded RNA-activated protein kinaseEIF2AK2 P19525
8 Reference(s)
T61LV9 Free fatty acid receptor 3FFAR3 O14843
1 Reference(s)
T76MVQ Free fatty acid receptor 4FFAR4 Q5NUL3
1 Reference(s)
T08U92 Mitochondrial brown fat uncoupling protein 1UCP1 P25874
1 Reference(s)
T18LX5 Neutrophil elastaseELANE P08246
1 Reference(s)
T03XRZ Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)PTP4A1 Q93096
1 Reference(s)
T64V6C Glutamate decarboxylase 1GAD1 Q99259
1 Reference(s)
T83RKS Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseMGAT1 P26572
2 Reference(s)
T73PZA Vesicular inhibitory amino acid transporterSLC32A1 Q9H598
1 Reference(s)
T68XXK 4-aminobutyrate aminotransferase, mitochondrialABAT P80404
4 Reference(s)
T35WLZ Sodium- and chloride-dependent GABA transporter 3SLC6A11 P48066
2 Reference(s)
T20JZ2 Androgen receptorAR P10275
2 Reference(s)
T41Z1X Gamma-aminobutyric acid receptor-associated proteinGABARAP O95166
1 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
1 Reference(s)
T80XW6 Scavenger receptor class B member 1SCARB1 Q8WTV0
1 Reference(s)
T02DEN Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptideGCG P01275
1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
11 Reference(s)
T76TED Pro-opiomelanocortinPOMC P01189
1 Reference(s)
T37JN5 Neutrophil gelatinase-associated lipocalinLCN2 P80188
1 Reference(s)
T17UP9 C-C motif chemokine 2CCL2 P13500
1 Reference(s)
T64UH1 Nitric oxide synthase, endothelialNOS3 P29474
1 Reference(s)
T22H8P Carbonic anhydrase 3CA3 P07451
1 Reference(s)
T38T1U Caspase-8CASP8 Q14790
1 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
4 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
3 Reference(s)
T74D4Y CASP8 and FADD-like apoptosis regulatorCFLAR O15519
1 Reference(s)
T95K8Q Intestinal-type alkaline phosphataseALPI P09923
1 Reference(s)
T98FWP NF-kappa-B essential modulatorIKBKG Q9Y6K9
1 Reference(s)
T94VM4 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239)HSD17B2 P37059
1 Reference(s)
T44LWL Transcription factor p65RELA Q04206
3 Reference(s)
T74I49 Bcl-2-like protein 1BCL2L1 Q07817
3 Reference(s)
T75HMM Induced myeloid leukemia cell differentiation protein Mcl-1MCL1 Q07820
3 Reference(s)
T14LSK E3 ubiquitin-protein ligase XIAPXIAP P98170
2 Reference(s)
T79KQO NF-kappa-B inhibitor alphaNFKBIA P25963
2 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
9 Reference(s)
T42XY2 Insulin-like growth factor 1 receptorIGF1R P08069
2 Reference(s)
T93WZG G1/S-specific cyclin-D1CCND1 P24385
6 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
9 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
5 Reference(s)
T54VQA Cyclin-dependent kinase inhibitor 2ACDKN2A P42771
2 Reference(s)
T07TMB Cyclin-dependent kinase 1CDK1 P06493
3 Reference(s)
T86UXL Cyclin-A2CCNA2 P20248
1 Reference(s)
T24LXT G2/mitotic-specific cyclin-B1CCNB1 P14635
5 Reference(s)
T64W2K Cyclin-dependent kinase inhibitor 1CDKN1A P38936
8 Reference(s)
T35QZO Cytochrome cCYCS P99999
1 Reference(s)
T06PVX E3 ubiquitin-protein ligase Mdm2MDM2 Q00987
2 Reference(s)
T91T8I Glucose-6-phosphatase catalytic subunit 1G6PC1 P35575
1 Reference(s)
T06IYF Adenomatous polyposis coli proteinAPC P25054
1 Reference(s)
T86ROZ Heme oxygenase 1HMOX1 P09601
2 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
4 Reference(s)
T50GQE Interleukin-13IL13 P35225
1 Reference(s)
T75H3W Cyclin-dependent kinase 2CDK2 P24941
3 Reference(s)
T10S5F Cyclin-dependent kinase 4CDK4 P11802
3 Reference(s)
T22IMH Cyclin-dependent kinase 6CDK6 Q00534
1 Reference(s)
T02WMA Ornithine decarboxylaseODC1 P11926
1 Reference(s)
T84P70 Urokinase-type plasminogen activatorPLAU P00749
2 Reference(s)
T36SOV Plasminogen activator inhibitor 1SERPINE1 P05121
1 Reference(s)
T62QDU Alpha- and gamma-adaptin-binding protein p34AAGAB Q6PD74
1 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
6 Reference(s)
T63GUB Proto-oncogene c-FosFOS P01100
2 Reference(s)
T80OJF Interstitial collagenaseMMP1 P03956
2 Reference(s)
T37VLU Interferon gammaIFNG P01579
2 Reference(s)
T88B8X Insulin receptorINSR P06213
2 Reference(s)
T68SE0 Solute carrier family 2, facilitated glucose transporter member 4SLC2A4 P14672
2 Reference(s)
T91OUC Mucin-5ACMUC5AC P98088
1 Reference(s)
T45G32 Proto-oncogene tyrosine-protein kinase SrcSRC P12931
2 Reference(s)
T21S10 Heterogeneous nuclear ribonucleoproteins A2/B1HNRNPA2B1 P22626
1 Reference(s)
T46K2X Heat shock 70 kDa protein 4HSPA4 P34932
1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
1 Reference(s)
T99XQ3 DNA topoisomerase 1TOP1 P11387
1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
1 Reference(s)
T47HTN Prostaglandin E synthasePTGES O14684
1 Reference(s)
T38K2W Receptor tyrosine-protein kinase erbB-2ERBB2 P04626
1 Reference(s)
T69NG6 Interleukin-10IL10 P22301
3 Reference(s)
T60GGR Serine/threonine-protein kinase TBK1TBK1 Q9UHD2
1 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
2 Reference(s)
T01E7W Aurora kinase BAURKB Q96GD4
1 Reference(s)
T77M4W Adenosine receptor A2aADORA2A P29274
1 Reference(s)
T62Y4H Protein kinase C epsilon typePRKCE Q02156
1 Reference(s)
T83YZD AcetylcholinesteraseACHE P22303
2 Reference(s)
T35LKG Adenosine receptor A1ADORA1 P30542
1 Reference(s)
T89L4V InsulinINS P01308
2 Reference(s)
T21Q0D 3-hydroxy-3-methylglutaryl-coenzyme A reductaseHMGCR P04035
1 Reference(s)
T16A2X CatalaseCAT P04040
1 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
1 Reference(s)
T01QLH Estrogen receptorESR1 P03372
3 Reference(s)
T43NBB Solute carrier family 2, facilitated glucose transporter member 2SLC2A2 P11168
1 Reference(s)
T51WGR Pancreas/duodenum homeobox protein 1PDX1 P52945
1 Reference(s)
T82S6C Hexokinase-4GCK P35557
1 Reference(s)
T18CPB Choline O-acetyltransferaseCHAT P28329
1 Reference(s)
T04V7K Ectonucleotide pyrophosphatase/phosphodiesterase family member 7ENPP7 Q6UWV6
1 Reference(s)
T51U9M Carnitine O-palmitoyltransferase 1, muscle isoformCPT1B Q92523
1 Reference(s)
T51EKP Apolipoprotein MAPOM O95445
1 Reference(s)
T07VV7 GuanylinGUCA2A Q02747
1 Reference(s)
T67ZT3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN P60484
1 Reference(s)
T80WPU Protein ABHD15ABHD15 Q6UXT9
1 Reference(s)
T56OUM 14-3-3 protein zeta/deltaYWHAZ P63104
1 Reference(s)
T24YWQ Insulin-degrading enzymeIDE P14735
1 Reference(s)
T34HYH Interleukin-1 alphaIL1A P01583
1 Reference(s)
T70HC9 Hepatocyte nuclear factor 1-alphaHNF1A P20823
1 Reference(s)
T49J7I Hepatocyte nuclear factor 4-alphaHNF4A P41235
1 Reference(s)
T67RBZ Mitochondrial uncoupling protein 2UCP2 P55851
1 Reference(s)
T98DNG Natriuretic peptides ANPPA P01160
1 Reference(s)
T78ILO Stearoyl-CoA desaturaseSCD O00767
2 Reference(s)
T68IZC Natriuretic peptides BNPPB P16860
1 Reference(s)
T02H9U Nuclear factor of activated T-cells, cytoplasmic 4NFATC4 Q14934
1 Reference(s)
T14ENF Microtubule-associated protein 2MAP2 P11137
1 Reference(s)
T78ZF2 Protein kinase C alpha typePRKCA P17252
1 Reference(s)
T93VFT Endothelin-1EDN1 P05305
1 Reference(s)
T04TWI CD40 ligandCD40LG P29965
1 Reference(s)
T41TXS Retinoblastoma-associated proteinRB1 P06400
1 Reference(s)
T92UBJ Acetyl-CoA carboxylase 1ACACA Q13085
1 Reference(s)
T87WMV Sodium/potassium-transporting ATPase subunit gammaFXYD2 P54710
1 Reference(s)
T00KKS Sodium/iodide cotransporterSLC5A5 Q92911
1 Reference(s)
T38BR0 G1/S-specific cyclin-D2CCND2 P30279
2 Reference(s)
T96G89 Fatty acid-binding protein, adipocyteFABP4 P15090
1 Reference(s)
T90ORW Bcl2-associated agonist of cell deathBAD Q92934
1 Reference(s)
T04UTZ G1/S-specific cyclin-E1CCNE1 P24864
1 Reference(s)
T22I6G Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)CDKN2C P42773
1 Reference(s)
T25S1M Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) (Fragment)p27 kip1 O43806
1 Reference(s)
T05PKX Steroid 17-alpha-hydroxylase/17,20 lyaseCYP17A1 P05093
1 Reference(s)
T74ETU Steroid 21-hydroxylaseCYP21A2 P08686
1 Reference(s)
T65S3S Tyrosine-protein kinase JAK2JAK2 O60674
1 Reference(s)
T27LTU C5a anaphylatoxin chemotactic receptor 1C5AR1 P21730
1 Reference(s)
T00QMT NAMIR15B NA
1 Reference(s)
T06ADX Tyrosine-protein kinase receptor UFOAXL P30530
1 Reference(s)
T30L86 Tumor necrosis factor receptor superfamily member 10BTNFRSF10B O14763
1 Reference(s)
T26EZU Myc proto-oncogene proteinMYC P01106
2 Reference(s)
T52RGZ Growth/differentiation factor 15GDF15 Q99988
1 Reference(s)
T54CIF Interleukin-8CXCL8 P10145
1 Reference(s)
T40JZG GPI-anchor transamidasePIGK Q92643
1 Reference(s)
T20TPU Histone acetyltransferase KAT2BKAT2B Q92831
1 Reference(s)
T57HGP Tumor necrosis factor receptor superfamily member 6FAS P25445
2 Reference(s)
T43N2D Epidermal growth factor receptorEGFR P00533
1 Reference(s)
T68AKE Zinc fingers and homeoboxes protein 2ZHX2 Q9Y6X8
1 Reference(s)
T73LPO Poly [ADP-ribose] polymerase 1PARP1 P09874
1 Reference(s)
T10K5R NAMIR203A NA
1 Reference(s)
T66WWM Claudin-2CLDN2 P57739
2 Reference(s)
T78O6C Mothers against decapentaplegic homolog 3SMAD3 P84022
1 Reference(s)
T92HNO High mobility group protein B1HMGB1 P09429
1 Reference(s)
T78IOY Telomerase reverse transcriptaseTERT O14746
1 Reference(s)
T41BXR NAD-dependent protein deacetylase sirtuin-3, mitochondrialSIRT3 Q9NTG7
1 Reference(s)
T41DXP PleiotrophinPTN P21246
1 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
1 Reference(s)
T62RLH NAMIR384 NA
1 Reference(s)
T87QUW Actin, aortic smooth muscleACTA2 P62736
1 Reference(s)
T04WT7 FibronectinFN1 P02751
1 Reference(s)
T04H8Y Beta-secretase 1BACE1 P56817
1 Reference(s)
T02IOG Cyclin-dependent kinase inhibitor 1BCDKN1B P46527
1 Reference(s)
T84FSA Forkhead box protein O3FOXO3 O43524
1 Reference(s)

Related Compounds  (Total: 18)

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C0094
Name: Gamma-Aminobutyric Acid
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C0416
Name: Stearic Acid
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C0285
Name: Palmitic Acid
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C0190
Name: Linolenic Acid
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C0189
Name: Linoleic Acid