Compound Description
| ID: C0094 | Common name: Gamma-Aminobutyric Acid |
| IUPAC: 4-aminobutanoic acid | CAS: CAS:56-12-2 |
| Chembl ID: CHEMBL96 | Pubchem ID: CID:119 |
| Formula: C4H9NO2 | TCM-ID: TCMC1209 |
| Smiles: C(CC(=O)O)CN | |
| Alias:
Butyric acid, 4-amino-;
4-Aminobutanoic acid; 3-Carboxypropylamine; 4-Aminobutyric acid; Aminalon; GABA; Gaballon; Gamarex; Gamma-aminobutyric acid; Gammalon; Gammalone; Gammar; Gammasol; Lacto Gaban; Mielogen; Mielomade; NSC 27418; NSC 32044; NSC 45460; NSC 51295; Oryza GABA Extract HC 90; Pharma GABA 30L; Pharma-GABA 20S; Pharmagaba; Pharmagaba 20; Pharmagaba 20D; Piperidic acid; Piperidinic acid; γ-Aminobutanoic acid; γ-Aminobutyric acid; ω-Aminobutyric acid |
Structure:
|
Related Targets (Total: 15)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
A | 2 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
B | 1 Reference(s) |
| T64V6C | Glutamate decarboxylase 1 | GAD1 |
Q99259 |
B | 1 Reference(s) |
| T83RKS | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | MGAT1 |
P26572 |
B | 2 Reference(s) |
| T73PZA | Vesicular inhibitory amino acid transporter | SLC32A1 |
Q9H598 |
B | 1 Reference(s) |
| T68XXK | 4-aminobutyrate aminotransferase, mitochondrial | ABAT |
P80404 |
B | 4 Reference(s) |
| T35WLZ | Sodium- and chloride-dependent GABA transporter 3 | SLC6A11 |
P48066 |
B | 2 Reference(s) |
| T20JZ2 | Androgen receptor | AR |
P10275 |
B | 1 Reference(s) |
| T41Z1X | Gamma-aminobutyric acid receptor-associated protein | GABARAP |
O95166 |
B | 1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
C | 1 Reference(s) |
| T43NBB | Solute carrier family 2, facilitated glucose transporter member 2 | SLC2A2 |
P11168 |
C | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
C | 1 Reference(s) |
| T51WGR | Pancreas/duodenum homeobox protein 1 | PDX1 |
P52945 |
C | 1 Reference(s) |
| T82S6C | Hexokinase-4 | GCK |
P35557 |
C | 1 Reference(s) |
| T18CPB | Choline O-acetyltransferase | CHAT |
P28329 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 58)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0677 | Chan Chu | 蟾蜍 | Toad | Bufo melanostictus |
| H1108 | Gua Lou Shi | 栝蒌实 | NA | Trichosanthes kirilowii |
| H1112 | Gua Lou Ren(1) | 栝楼仁 | NA | Trichosanthes kirilowii |
| H0452 | Shi Chang Pu Qing Gao | 石菖蒲清膏 | Grassleaved sweetflag | Acorus tatarinowii |
| H0881 | Chuan Qiang Huo | 川羌活 | Incised notopterygium | Notopterygium incisum |
| H0265 | Mu Da Qing Ye | 木大青叶 | Indigo-coloured woad leaf equivalent | Isatis indigotica |
| H0451 | Shi Chang Pu Jin Gao | 石菖蒲浸膏 | Grassleaved sweetflag | Acorus tatarinowii |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H1156 | Ai Di Huang | 矮地黄 | Rehmanniae | Rehmannia glutinosa |
| H0159 | Ban Xia Qu | 半夏曲 | Pinellia tuber leaven | Pinellia ternata |
| H0956 | Dang Gui Gan Jin Gao | 当归干浸膏 | NA | Angelica sinensis |
| H1024 | Fa Ban Xia | 法半夏 | Prepared pinellia tuber | Rhizoma pinelliae preparata |
| H0293 | Niu Jiao Tan | 牛角炭 | Buffalo horn | Bubalus bubalis |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H1104 | Gua Lou | 瓜蒌 | NA | Trichosanthes kirilowii |
| H0338 | Qing Ban Xia | 清半夏 | Ternate pinellia | Pinellia ternata |
| H0473 | Shu Di Huang | 熟地黄 | Adhesive rehmannia cocked root | Rehmannia glutinosa |
| H1105 | Gua Lou Pi | 瓜蒌皮 | NA | Trichosanthes kirilowii |
| H1111 | Gua Lou Gen | 栝楼根 | NA | Trichosanthes kirilowii |
| H0137 | Ban Lan Gen | 板蓝根 | Indigowoad root | Isatis indigotica |
| H0292 | Niu Jiao Jian Fen | 牛角尖粉 | Buffalo horn | Bubalus bubalis |
| H0441 | Sheng Di Huang | 生地黄 | Fresh rehmannia root | Radix rehmanniae |
| H0937 | Da Qing Ye | 大青叶 | Indigo-coloured woad leaf | Isatis indigotica |
| H0579 | Tu Sheng Di | 土生地 | Fresh rehmannia root | Radix rehmanniae |
| H0155 | Ban Xia | 半夏 | Ternate pinellia | Pinellia ternata |
| H0331 | Qiang Huo | 羌活 | Incised notopterygium | Notopterygium incisum |
| H0489 | Shui Niu Jiao Nong Suo Fen | 水牛角浓缩粉 | Buffalo horn | Bubalus bubalis |
| H0131 | Ban Lan | 板蓝 | Indigowoad root | Isatis indigotica |
| H1009 | Du Huo | 独活 | Doubleteeth pubescent angelica | Angelica pubescens |
| H0868 | Chuan Du Huo | 川独活 | Doubleteeth pubescent angelica | Angelica pubescens |
| H0094 | Gou Qi | 枸杞 | Chinese wolfberry fruit | Lycium chinense |
| H1226 | Huai Shan Yao | 淮山药 | rhizome of biglcaf yam | Rhizoma dioscoreae |
| H1078 | Gan Chan | 干蟾 | NA | Bufo melanostictus |
| H0291 | Niu Jiao Fen | 牛角粉 | Buffalo horn | Bubalus bubalis |
| H0488 | Shui Niu Jiao Gan Jin Gao | 水牛角干浸膏 | Buffalo horn | Bubalus bubalis |
| H0620 | Xi Gua | 西瓜 | Watermelon | Citrullus vulgaris |
| H0650 | Chai Hu | 柴胡 | Chinese thorowax | Bupleurum chinense |
| H0714 | Yan Tai Chai Hu | 烟台柴胡 | Chinese thorowax | Bupleurum chinense |
| H1107 | Gua Lou Ren Shuang | 瓜蒌仁霜 | NA | Trichosanthes kirilowii |
| H1079 | Gan Di Huang | 干地黄 | Adhesive rehmannia dried root | Rehmannia glutinosa |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0955 | Dang Gui | 当归 | Chinese angelica | Angelica sinensis |
| H0439 | Sheng Ban Xia | 生半夏 | Ternate pinellia | Pinellia ternata |
| H0539 | Tian Hua Fen | 天花粉 | Mongolian snakegourd root | Trichosanthes kirilowii |
| H1088 | Gan Zhe | 甘蔗 | Sweetcane culm | Saccharum sinensis |
| H0263 | Mu Ban Lan Gen | 木板蓝根 | Indigowoad root | Isatis indigotica |
| H0450 | Shi Chang Pu | 石菖蒲 | Grassleaved sweetflag | Acorus tatarinowii |
| H1106 | Gua Lou Ren | 瓜蒌仁 | NA | Trichosanthes kirilowii |
| H0095 | Gou Qi Zi | 枸杞子 | Chinese wolfberry fruit | Lycium chinense |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H0665 | Chai Hu Shao | 柴胡梢 | Chinese thorowax | Bupleurum chinense |
| H0973 | Di Huang Tan | 地黄炭 | Rehmanniae | Rehmannia glutinosa |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H0659 | Chai Hu Jin Gao | 柴胡浸膏 | Chinese thorowax | Bupleurum chinense |
| H0487 | Shui Niu Jiao | 水牛角 | Buffalo horn | Bubalus bubalis |
| H0173 | Lu Hui | 芦荟 | Kulaso aloe dried juice | Aloe vera |
| H0442 | Sheng Di Huang Zhi | 生地黄汁 | Fresh rehmannia root | Radix rehmanniae |
| H0972 | Di Huang | 地黄 | Rehmanniae | Rehmannia glutinosa |
Ckey description of the interaction between compound and target