Target Description

Type Detail
Target ID T42D4V
Protein Name Histone deacetylase 1
Uniprot ID Q13547
Protein Name Alias HD1;  EC 3.5.1.98
Gene ID 3065
Gene Symbol HDAC1
Gene Alias RPD3L1
TTD T68547: Successful target
Pfam PF00850
GO
0006325:chromatin organization

0032991:protein-containing complex

0010629:negative regulation of gene expression

0070933:histone H4 deacetylation

0070888:E-box binding

0032041:NAD-dependent histone deacetylase activity (H3-K14 specific)

0016575:histone deacetylation

0043066:negative regulation of apoptotic process

0090090:negative regulation of canonical Wnt signaling pathway

1900221:regulation of amyloid-beta clearance

0043025:neuronal cell body

0008134:transcription factor binding

0043922:negative regulation by host of viral transcription

0052548:regulation of endopeptidase activity

1901796:regulation of signal transduction by p53 class mediator

0016580:Sin3 complex

1904837:beta-catenin-TCF complex assembly

0007596:blood coagulation

0033558:protein deacetylase activity

0016581:NuRD complex

0005829:cytosol

0030182:neuron differentiation

0070932:histone H3 deacetylation

0001103:RNA polymerase II repressing transcription factor binding

0051059:NF-kappaB binding

0035851:Krueppel-associated box domain binding

0021766:hippocampus development

0060789:hair follicle placode formation

0003714:transcription corepressor activity

0005654:nucleoplasm

0033613:activating transcription factor binding

0070491:repressing transcription factor binding

0019899:enzyme binding

1990841:promoter-specific chromatin binding

0042475:odontogenesis of dentin-containing tooth

0005737:cytoplasm

0001046:core promoter sequence-specific DNA binding

0002039:p53 binding

2001243:negative regulation of intrinsic apoptotic signaling pathway

0045893:positive regulation of transcription, DNA-templated

0006346:DNA methylation-dependent heterochromatin assembly

0006476:protein deacetylation

0006338:chromatin remodeling

0000785:chromatin

0000792:heterochromatin

0045944:positive regulation of transcription by RNA polymerase II

0009913:epidermal cell differentiation

0005634:nucleus

0060766:negative regulation of androgen receptor signaling pathway

0001085:RNA polymerase II transcription factor binding

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0008284:positive regulation of cell population proliferation

0006367:transcription initiation from RNA polymerase II promoter

0042826:histone deacetylase binding

0000118:histone deacetylase complex

0019213:deacetylase activity

0032922:circadian regulation of gene expression

0042733:embryonic digit morphogenesis

0043044:ATP-dependent chromatin remodeling

0061029:eyelid development in camera-type eye

0045892:negative regulation of transcription, DNA-templated

0048714:positive regulation of oligodendrocyte differentiation

0004407:histone deacetylase activity

0045652:regulation of megakaryocyte differentiation

0000122:negative regulation of transcription by RNA polymerase II

0043124:negative regulation of I-kappaB kinase/NF-kappaB signaling

0000979:RNA polymerase II core promoter sequence-specific DNA binding

0061198:fungiform papilla formation

2000273:positive regulation of signaling receptor activity

0007492:endoderm development

0047485:protein N-terminus binding

0006357:regulation of transcription by RNA polymerase II

PDB 4BKX ; 7AO8 ; 6Z2K ; 7AOA ; 6Z2J ; 1TYI ; 7AO9 ; 5ICN
Drugbank DB14533 ; DB05223 ; DB02546 ; DB12565 ; DB14548 ; DB06603 ; DB08868 ; DB06176 ; DB01169 ; DB01593 ; DB05015 ; DB14487 ; DB11830
KEGG hsa:3065

Related Compounds  (Total: 6)

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C0012
Name: Diazepam
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C0219
Name: Methyleugenol
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C0226
Name: Morphine
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C0477
Name: Valproic Acid
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C0739
Name: (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione


Related Herbs  (Total: 219)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H0713 Che Qian Cao车前草 all-grass of rippleseed plantainPlantago depressa
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0613 Wu Yue Ai五月艾 ArtemisiaArtemisia princeps
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H0148 Ling Ling Xiang零陵香 NAOcimum basilicum
H0071 Bai Ye柏叶 Chinese arborvitae twigPlatycladus orientalis
H0802 Zhi Geng枳梗 NACitrus aurantium
H1090 Gao Ben藁本 Chinese ligusticumLigusticum sinense
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H1021 E Da Xia莪大夏 NAOxytropis falcata
H0338 Qing Ban Xia清半夏 Ternate pinelliaPinellia ternata
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H0074 Jing Jie Tan荆芥炭 NASchizonepetae herba
H1219 Hua Sheng Mi花生米 NAArachis hypogaea
H0727 Ye Gan Cao野甘草 Sweet broomwortScoparia dulcis
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0457 Shi Er石耳 Rock-EarsUmbilicaria esculenta
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0957 Dang Gui Teng当归藤 NAEmbelia parviflora
H0239 Bei Sha Shen北沙参 Coastal glehniaGlehnia littoralis
H0821 Chu Ling Dan Cao臭灵丹草 laggera pterodontaLaggera pterodonta
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium
H0142 Liang Jiang良姜 NAAlpinia officinarum
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H0585 Tu Yin Chen Hao土茵陈蒿 Capillary wormwoodArtemisia capillaris
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0674 Xin Yi辛夷 Lily magnolia budsMagnolia liliflora
H0026 Jiang Soybean pasteGlycine max
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0708 Yuan Hua Gen芫花根 Lilac daphne rootDaphne genkwa
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H1249 Huang Qi Jin Gao黄芪浸膏 Membranous milkvetchAstragalus membranaceus
H0242 Bei Sha Shen Liu Jin Gao北沙参流浸膏 Glehnia littoralisGlehnia littoralis
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0822 Zhou Ye Xiang Ru皱叶香薷 Haichow elsholtziaElsholtzia splendens
H0089 Ju Hong橘红 NACitri exocarpium rubrum
H1107 Gua Lou Ren Shuang瓜蒌仁霜 NATrichosanthes kirilowii
H1138 Bai Jiang Cao败酱草 All - grass of dahurian patriniaThlaspi arvense
H0183 Luo Hua Sheng Zhi Ye落花生枝叶 Peanut branch-leafArachis hypogaea
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H0746 Yin Chen Hao Gan Jin Gao茵陈蒿干浸膏 Capillary wormwoodArtemisia capillaris
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H0185 Luo Shi Teng络石藤 Chinese star jasmineTrachelospermum jasminoides
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0300 Nv Zhen Zi女贞子 Glossy privet fruitLigustrum lucidum
H0676 Xin Yi Hua Jin Gao Fen辛夷花浸膏粉 MagnoliaMagnolia liliflora
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H0568 Tu Er Cao兔耳草 LagotisLagotis brevituba
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0638 Xiang Bei象贝 FritillariaFritillaria thunbergii
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0920 Da Ban Bian Lian大半边莲 Asian lobeliaLobelia chinensis
H1133 Gui Jian Yu鬼箭羽 Winged euonymusEuonymus alatus
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H0590 Wei Ling威灵 Chinese clematisClematis chinensis
H0901 Chun Gen Teng春根藤 Twig and leaf of creeping psychotriaPsychotria serpens
H0418 Shan Yin Chen山茵陈 Capillary wormwoodArtemisia capillaris
H0247 Mi Meng Hua密蒙花 Pale butterflybushBuddleja officinalis
H0855 Chuan Bei Mu川贝母 Fritillaria unibracteataFritillaria cirrhosa
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1247 Huang Qi黄芪 Membranous milkvetchAstragalus membranaceus
H0968 Di Feng Pi地枫皮 Difengpi anisetreeIllicium difengpi
H0080 Jiu Ceng Ta九层塔 BasilOcimum basilicum
H1105 Gua Lou Pi瓜蒌皮 NATrichosanthes kirilowii
H0887 Chuan Xin Lian Gan Jin Gao穿心莲干浸膏 Common andrographisAndrographis paniculata
H0691 Xue Lian Hua雪莲花 Snow lotusSaussurea involucrata
H0696 Ya Jiao Ai鸭脚艾 Ghostplant wormwoodArtemisia lactiflora
H0692 Xue Ren Shen血人参 NALespedeza bicolor
H0769 Yuan Zhi远志 Thinleaf milkwortPolygala tenuifolia
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0974 Di Jin Cao地锦草 Humifuse euphorbiaEuphorbia humifusa
H0663 Xiao Ji小蓟 Setose thistleCirsium setosum
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0150 Ling Xian灵仙 root and rhizome of smilaxRadix smilacis
H1218 Hua Sheng花生 NAArachis hypogaea
H0668 Xiao Ye Huang Yang小叶黄杨 Small-leaved boxBuxus microphylla
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H0450 Shi Chang Pu石菖蒲 Grassleaved sweetflagAcorus tatarinowii
H0711 Yuan Hua Zhi Tiao芫花枝条 stem of lilac daphneDaphne genkwa
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H0580 Tu Si Rou菟丝肉 Dodder seedCuscuta australis
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0581 Tu Si Zi菟丝子 Dodder seedCuscuta australis
H0678 Xin Yi Ren辛夷仁 MagnoliaMagnolia liliflora
H0477 Shu Jiao蜀椒 Pricklyash peelPericarpium zanthoxyli
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0554 Tie Si Wei Ling Xian铁丝威灵仙 root and rhizome of smilaxRadix smilacis
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0592 Wei Ling Xian威灵仙 Chinese clematisClematis chinensis
H0193 Ma Bian Cao马鞭草 European verbenaVerbena officinalis
H0871 Chuan Duan川断 TeaselsDipsacus asper
H0100 Juan Bai卷柏 Tamariskoid spikemossSelaginella tamariscina
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H0184 Luo Le罗勒 BasilOcimum basilicum
H0427 Shan Zhu Yu山茱萸 Asiatic cornelian cherryCornus officinalis
H0365 Rou Dou Kou肉豆蔻 Common nutmegMyristica fragrans
H0918 Cu Yuan Hua醋芫花 Lilac daphneDaphne genkwa
H0152 Ling Zhi Jin Gao灵芝浸膏 NAGanoderma lucidum
H0508 Su Geng苏梗 stem of common perillaCaulis perillae frutescentis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0889 Chuan Xin Lian Jin Gao穿心莲浸膏 Common andrographisAndrographis paniculata
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0218 Man Jiu Jie蔓九节 Creeping ninenodePsychotria serpens
H0094 Gou Qi枸杞 Chinese wolfberry fruitLycium chinense
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H1248 Huang Qi Gan Jin Gao黄芪干浸膏 Membranous milkvetchAstragalus membranaceus
H1007 Dou You豆油 Soybean oilGlycine max
H0805 Zhi Ke Gan Jin Gao枳壳干浸膏 Seville ora nge unripe fruitCitrus aurantium
H0237 Mei Gui Hua玫瑰花 Rugose rose flowerRosa rugosa
H0892 Chuan Xiong川芎 cnidium officinaleCnidium officinale
H0583 Tu Si Zi Teng菟丝子藤 Dodder seedCuscuta australis
H0771 Yuan Zhi Liu Jin Gao远志流浸膏 Thinleaf milkwortPolygala tenuifolia
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H0826 Chu Mu Dan臭牡丹 rose glorybowerClerodendrum bungei
H1214 Hua Jiao花椒 Bunge pricklyashZanthoxylum bungeanum
H0248 Mi Ying Su Ke蜜罂粟壳 Opium poppyPapaver somniferum
H0085 Jiu Yu Rou酒萸肉 Asiatic cornelian cherryCornus officinalis
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H0745 Yin Chen Hao茵陈蒿 Capillary wormwoodArtemisia capillaris
H0664 Xiao Ji Tan小蓟炭 ThistleCirsium arvense
H0279 Nan Gua南瓜 CushawCucurbita moschata
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0757 Ying Su Ke罂粟壳 Opium poppy pericarpPapaver somniferum
H0729 Ye Ju Hua野菊花 Indian wild chrysanthemum flowerChrysanthemum indicum
H0370 Ru Xiang乳香 OlibanumBoswellia carterii
H1106 Gua Lou Ren瓜蒌仁 NATrichosanthes kirilowii
H0439 Sheng Ban Xia生半夏 Ternate pinelliaPinellia ternata
H0859 Chuan Bei Mu Liu Jin Gao川贝母流浸膏 Fritillaria unibracteataFritillaria cirrhosa
H0886 Chuan Xin Lian穿心莲 Common andrographisAndrographis paniculata
H0095 Gou Qi Zi枸杞子 Chinese wolfberry fruitLycium chinense
H0710 Yuan Hua Tiao芫花条 stem of lilac daphneDaphne genkwa
H0524 Tan Xiang檀香 SandalwoodSantalum album
H0816 Chu Ling Dan臭灵丹 laggera pterodontaLaggera pterodonta
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0498 Si Ji Cai四季菜 Ghostplant wormwoodArtemisia lactiflora
H0546 Tian Shan Xue Lian Hua天山雪莲花 NASaussurea involucrata
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0214 Bei He Huan北合欢 AlbiziaAlbizia julibrissin
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin
H0948 Dan Nan Xing胆南星 Bile arisaemaRhizoma arisaema cum bile
H0159 Ban Xia Qu半夏曲 Pinellia tuber leavenPinellia ternata
H0675 Xin Yi Hua辛夷花 MagnoliaMagnolia liliflora
H0707 Yuan Hua芫花 Lilac daphneDaphne genkwa
H1185 Hong Dou Kou红豆蔻 Galanga galangal fruitFructus galangae
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0505 Cang Chang Pu藏菖蒲 Sweet flagAcorus calamus
H0673 Xin Jiang Zi Cao新疆紫草 Arnebia rootArnebia euchroma
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H0518 Suo Sha Ren缩砂仁 Villous amomum fruitFructus amomi
H0072 Jing Jie荆芥 Fineleaf schizonepetaSchizonepeta tenuifolia
H1198 Hou Tou Jun猴头菌 Bearded tooth carpophoreHericium erinaceus
H0496 Shui Ze Lan水泽兰 NALycopus lucidus
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H0953 Dan Xing胆星 Bile arisaemaRhizoma arisaema cum bile
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0629 Xi Xin细辛 Siebold wildgingerAsarum sieboldii
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H1250 Huang Qi Ti Qu Ye黄芪提取液 Membranous milkvetchAstragalus membranaceus
H0273 Mu Tong木通 Fiveleaf akebiaAkebia quinata
H0642 Xiang Jia Pi香加皮 Chinese silkvine root-barkPeriploca sepium
H0890 Chuan Xin Lian Nong Suo Ye穿心莲浓缩液 Common andrographisAndrographis paniculata
H0975 Di Mian Cao地绵草 NAEuphorbia humifusa
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0153 Ling Zhi(1)灵芝 Lucid ganodermaGanoderma lucidum
H0073 Jing Jie Sui荆芥穗 NASchizonepetae spica
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0647 Xiang Ru香薷 Haichow elsholtziaElsholtzia splendens
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0155 Ban Xia半夏 Ternate pinelliaPinellia ternata
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0844 Zi Cao紫草 Redroot gromwellLithospermum erythrorhizon
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H1128 Bai Jiang败酱 Whiteflower patriniaPatrinia villosa
H1112 Gua Lou Ren(1)栝楼仁 NATrichosanthes kirilowii
H0451 Shi Chang Pu Jin Gao石菖蒲浸膏 Grassleaved sweetflagAcorus tatarinowii
H0893 Chuan Xiong Jin Gao川芎浸膏 cnidium officinaleCnidium officinale
H1141 Guo Gang Long Jin Gao过岗龙浸膏 NAEntada phaseoloides
H1140 Guo Gang Long过岗龙 NAEntada phaseoloides
H1104 Gua Lou瓜蒌 NATrichosanthes kirilowii
H1006 Dou Kou豆蔻 Round cardamon fruitFructus amomi rotundus
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H0452 Shi Chang Pu Qing Gao石菖蒲清膏 Grassleaved sweetflagAcorus tatarinowii
H0113 Ban Bian Lian半边莲 Chinese lobeliaLobelia chinensis
H1111 Gua Lou Gen栝楼根 NATrichosanthes kirilowii
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0690 Xue Lian雪莲 Snow lotusSaussurea involucrata
H1108 Gua Lou Shi栝蒌实 NATrichosanthes kirilowii
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0756 Ying Su罂粟 Opium poppyPapaver somniferum
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H0539 Tian Hua Fen天花粉 Mongolian snakegourd rootTrichosanthes kirilowii
H0770 Yuan Zhi Jin Gao远志浸膏 Thinleaf milkwortPolygala tenuifolia
H0204 Ma Ren麻仁 NACannabis sativa