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Compound Description

ID:   C0226 Common name:   Morphine
IUPAC:  (4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol CAS:  CAS:57-27-2
Chembl ID:   CHEMBL70 Pubchem ID:   CID:5288826
Formula:  C17H19NO3 TCM-ID:  TCMC1600
Smiles:  CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
Alias:

Morphinan-3,6α-diol, 7,8-didehydro-4,5α-epoxy-17-methyl-;

(5α,6α)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol;

(-)-Morphine;

10-Hydroxymorphine;

Aguettant;

DepoDur;

Dimorf;

Dinamorf;

Dulcontin;

Duromorph;

M-Eslon;

MS Contin;

Meconium;

Morphia;

Morphin;

Morphina;

Morphine;

Morphinism;

Morphinum;

Morphium;

Nepenthe;

Ospalivina;

Sevredol;

Statex SR;

l-Morphine
Structure:

Related Targets  (Total: 83)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T85AXP Cytochrome P450 3A4CYP3A4 P08684
 A 1 Reference(s)
T66YJ0 Mu-type opioid receptorOPRM1 P35372
 A 3 Reference(s)
T30VNV MyeloperoxidaseMPO P05164
 A 1 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
 A 2 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
 A 1 Reference(s)
T44C7S Gastrin/cholecystokinin type B receptorCCKBR P32239
 A 1 Reference(s)
T73WJH Calcium/calmodulin-dependent protein kinase kinase 2CAMKK2 Q96RR4
 B 1 Reference(s)
T16A2X CatalaseCAT P04040
 B 1 Reference(s)
T85Y6T Adenylate cyclase type 8ADCY8 P40145
 B 1 Reference(s)
T33OPP Interleukin-6IL6 P05231
 B 2 Reference(s)
T63GUB Proto-oncogene c-FosFOS P01100
 B 1 Reference(s)
T51WML Glutamate receptor 1GRIA1 P42261
 B 1 Reference(s)
T85U8U Caspase-3CASP3 P42574
 B 2 Reference(s)
T34DZ7 Interleukin-2IL2 P60568
 B 3 Reference(s)
T00EP2 Tissue-type plasminogen activatorPLAT P00750
 B 1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
 B 2 Reference(s)
T37VLU Interferon gammaIFNG P01579
 B 2 Reference(s)
T23TJV Tyrosine 3-monooxygenaseTH P07101
 B 1 Reference(s)
T08OEP Monocyte differentiation antigen CD14CD14 P08571
 B 1 Reference(s)
T86CQC Glutamate receptor ionotropic, NMDA 1GRIN1 Q05586
 B 3 Reference(s)
T74SS7 Glutamate receptor ionotropic, NMDA 2AGRIN2A Q12879
 B 1 Reference(s)
T27ZM7 Disks large homolog 4DLG4 P78352
 B 1 Reference(s)
T54IMC Vesicular glutamate transporter 1SLC17A7 Q9P2U7
 B 1 Reference(s)
T50V79 Interleukin-4IL4 P05112
 B 2 Reference(s)
T66A7X Activity-regulated cytoskeleton-associated proteinARC Q7LC44
 B 1 Reference(s)
T96N1K Calcium/calmodulin-dependent protein kinase type IVCAMK4 Q16566
 B 1 Reference(s)
T75B9S Cyclic AMP-responsive element-binding protein 1CREB1 P16220
 B 2 Reference(s)
T19EKF CholecystokininCCK P06307
 B 1 Reference(s)
T12WTT Interleukin-5IL5 P05113
 B 1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
 B 2 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
 B 2 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
 B 1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
 B 2 Reference(s)
T70SFS Superoxide dismutase [Mn], mitochondrialSOD2 P04179
 B 1 Reference(s)
T64X48 C-X-C chemokine receptor type 4CXCR4 P61073
 B 1 Reference(s)
T02OOS C-C chemokine receptor type 5CCR5 P51681
 B 2 Reference(s)
T88ENR Beta-arrestin-1ARRB1 P49407
 B 1 Reference(s)
T45FPZ Antizyme inhibitor 2AZIN2 Q96A70
 B 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
 B 2 Reference(s)
T57HGP Tumor necrosis factor receptor superfamily member 6FAS P25445
 B 1 Reference(s)
T32JN2 Beta-glucuronidaseGUSB P08236
 B 1 Reference(s)
T11BI7 Toll-like receptor 4TLR4 O00206
 B 1 Reference(s)
T96U07 Myristoylated alanine-rich C-kinase substrateMARCKS P29966
 B 1 Reference(s)
T04LY5 Creatine kinase B-typeCKB P12277
 B 2 Reference(s)
T17TKM Melanocortin receptor 4MC4R P32245
 C 1 Reference(s)
T05WWN CorticoliberinCRH P06850
 C 1 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
 C 1 Reference(s)
T74JJN Fatty acid synthaseFASN P49327
 C 2 Reference(s)
T02GD4 Tumor necrosis factor ligand superfamily member 6FASLG P48023
 C 2 Reference(s)
T18R9N Neuroendocrine convertase 1PCSK1 P29120
 C 1 Reference(s)
T47UGF Neuroendocrine convertase 2PCSK2 P16519
 C 1 Reference(s)
T00CXT Prostaglandin G/H synthase 1PTGS1 P23219
 C 1 Reference(s)
T55KUF Guanine nucleotide-binding protein subunit alpha-12GNA12 Q03113
 C 1 Reference(s)
T56G7O Acyl-CoA-binding proteinDBI P07108
 C 2 Reference(s)
T45TMC 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1PLCG1 P19174
 C 1 Reference(s)
T02HVB MidkineMDK P21741
 C 1 Reference(s)
T51UV4 Trans-acting T-cell-specific transcription factor GATA-3GATA3 P23771
 C 1 Reference(s)
T92LK2 Tumor necrosis factor ligand superfamily member 10TNFSF10 P50591
 C 1 Reference(s)
T35KD8 C-C chemokine receptor type 3CCR3 P51677
 C 1 Reference(s)
T54YW8 C-C motif chemokine 4CCL4 P13236
 C 1 Reference(s)
T04WTG Mitogen-activated protein kinase 10MAPK10 P53779
 C 1 Reference(s)
T43DMF Kappa-type opioid receptorOPRK1 P41145
 C 1 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
 C 2 Reference(s)
T46K2X Heat shock 70 kDa protein 4HSPA4 P34932
 C 1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
 C 1 Reference(s)
T26EZU Myc proto-oncogene proteinMYC P01106
 C 1 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
 C 1 Reference(s)
T79UQC C-X-C motif chemokine 10CXCL10 P02778
 C 1 Reference(s)
T12T4H Brain-derived neurotrophic factorBDNF P23560
 C 1 Reference(s)
T46PRA Excitatory amino acid transporter 3SLC1A1 P43005
 C 1 Reference(s)
T31VDH Myeloid differentiation primary response protein MyD88MYD88 Q99836
 C 1 Reference(s)
T60UPF Parvalbumin alphaPVALB P20472
 C 1 Reference(s)
T17E49 Cannabinoid receptor 1CNR1 P21554
 C 1 Reference(s)
T67KTV Transient receptor potential cation channel subfamily V member 1TRPV1 Q8NER1
 C 1 Reference(s)
T17CNB ThioredoxinTXN P10599
 C 1 Reference(s)
T19HN8 UDP-glucuronosyltransferase 2B7UGT2B7 P16662
 C 1 Reference(s)
T22V6A Eukaryotic translation initiation factor 2-alpha kinase 3EIF2AK3 Q9NZJ5
 C 1 Reference(s)
T47YVM Serine/threonine-protein kinase Sgk1SGK1 O00141
 C 1 Reference(s)
T90LA2 Sphingomyelin phosphodiesteraseSMPD1 P17405
 C 1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
 C 2 Reference(s)
T16KVU Tumor necrosis factor receptor superfamily member 1ATNFRSF1A P19438
 C 1 Reference(s)
T42D4V Histone deacetylase 1HDAC1 Q13547
 C 1 Reference(s)
T00T9M Thrombospondin-1THBS1 P07996
 C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 3)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0248 Mi Ying Su Ke蜜罂粟壳 Opium poppyPapaver somniferum
H0757 Ying Su Ke罂粟壳 Opium poppy pericarpPapaver somniferum
H0756 Ying Su罂粟 Opium poppyPapaver somniferum

Ckey description of the interaction between compound and target


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