Target Description

Type Detail
Target ID T90LA2
Protein Name Sphingomyelin phosphodiesterase
Uniprot ID P17405
Protein Name Alias EC 3.1.4.12;  Acid sphingomyelinase;  aSMase
Gene ID 6609
Gene Symbol SMPD1
Gene Alias ASM
TTD NA
Pfam PF00149
GO
0061750:acid sphingomyelin phosphodiesterase activity

0006687:glycosphingolipid metabolic process

0035307:positive regulation of protein dephosphorylation

0045807:positive regulation of endocytosis

0070062:extracellular exosome

0034340:response to type I interferon

0007399:nervous system development

0010212:response to ionizing radiation

0034644:cellular response to UV

0001778:plasma membrane repair

0070555:response to interleukin-1

0005615:extracellular space

0034612:response to tumor necrosis factor

0006685:sphingomyelin catabolic process

0005886:plasma membrane

0005764:lysosome

0042599:lamellar body

0042493:response to drug

0046718:viral entry into host cell

0006684:sphingomyelin metabolic process

0043202:lysosomal lumen

0071277:cellular response to calcium ion

0009615:response to virus

0023021:termination of signal transduction

0043065:positive regulation of apoptotic process

0036019:endolysosome

0004767:sphingomyelin phosphodiesterase activity

0008270:zinc ion binding

0007165:signal transduction

0008081:phosphoric diester hydrolase activity

0005811:lipid droplet

0043407:negative regulation of MAP kinase activity

0042060:wound healing

0016798:hydrolase activity, acting on glycosyl bonds

0046513:ceramide biosynthetic process

0008203:cholesterol metabolic process

0005768:endosome

0042220:response to cocaine

PDB 5JG8 ; 5I8R ; 5I81 ; 5I85
Drugbank DB14009 ; DB00381 ; DB00477 ; DB01151
KEGG hsa:6609

Related Compounds  (Total: 3)

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C0080
Name: Fluoxetine
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C0205
Name: Mangostin
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C0226
Name: Morphine


Related Herbs  (Total: 9)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0968 Di Feng Pi地枫皮 Difengpi anisetreeIllicium difengpi
H0248 Mi Ying Su Ke蜜罂粟壳 Opium poppyPapaver somniferum
H0532 Teng Huang藤黄 Gamboge tree resinGarcinia morella
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0757 Ying Su Ke罂粟壳 Opium poppy pericarpPapaver somniferum
H0756 Ying Su罂粟 Opium poppyPapaver somniferum
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza