HIT-result

Type	Detail
Target ID	T27ZM7
Protein Name	Disks large homolog 4
Uniprot ID	P78352
Protein Name Alias	Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90; SAP-90; SAP90
Gene ID	1742
Gene Symbol	DLG4
Gene Alias	PSD95
TTD	T04507: Clinical Trial target
Pfam	PF10608 ; PF00018 ; PF00595 ; PF10600 ; PF00625
GO	0019900:kinase binding 0045202:synapse 2000463:positive regulation of excitatory postsynaptic potential 0045184:establishment of protein localization 2000821:regulation of grooming behavior 0035176:social behavior 0031812:P2Y1 nucleotide receptor binding 2000310:regulation of NMDA receptor activity 0060076:excitatory synapse 0005829:cytosol 0032839:dendrite cytoplasm 0014069:postsynaptic density 0097110:scaffold protein binding 0032281:AMPA glutamate receptor complex 0007612:learning 0008022:protein C-terminus binding 0098970:postsynaptic neurotransmitter receptor diffusion trapping 0031594:neuromuscular junction 0060997:dendritic spine morphogenesis 0007399:nervous system development 0098978:glutamatergic synapse 0043113:receptor clustering 0007204:positive regulation of cytosolic calcium ion concentration 0065003:protein-containing complex assembly 0044306:neuron projection terminus 0044309:neuron spine 0031748:D1 dopamine receptor binding 0048169:regulation of long-term neuronal synaptic plasticity 0035641:locomotory exploration behavior 0016188:synaptic vesicle maturation 0061098:positive regulation of protein tyrosine kinase activity 0035255:ionotropic glutamate receptor binding 0030165:PDZ domain binding 0005783:endoplasmic reticulum 0098839:postsynaptic density membrane 0045211:postsynaptic membrane 0044877:protein-containing complex binding 0035418:protein localization to synapse 0007165:signal transduction 0098609:cell-cell adhesion 0030863:cortical cytoskeleton 0097109:neuroligin family protein binding 0035865:cellular response to potassium ion 0019903:protein phosphatase binding 0000165:MAPK cascade 0097120:receptor localization to synapse 0097113:AMPA glutamate receptor clustering 0050885:neuromuscular process controlling balance 0030054:cell junction 0031697:beta-1 adrenergic receptor binding 0071625:vocalization behavior 0031234:extrinsic component of cytoplasmic side of plasma membrane 0050806:positive regulation of synaptic transmission 0043197:dendritic spine 0044300:cerebellar mossy fiber 0008021:synaptic vesicle 0005886:plasma membrane 0002091:negative regulation of receptor internalization 0097060:synaptic membrane 0043005:neuron projection 0005737:cytoplasm 0030666:endocytic vesicle membrane 0044224:juxtaparanode region of axon 0033130:acetylcholine receptor binding 0007268:chemical synaptic transmission 0150012:positive regulation of neuron projection arborization
PDB	6QJL ; 6QJF ; 6QJK ; 6QJG ; 6QJJ ; 2MES ; 5JXB ; 6QJD ; 6QJI ; 1KEF ; 3ZRT ; 6QJN ; 3I4W ; 3K82 ; 5J7J ; 6SPV ; 6SPZ
Drugbank	DB00536 ; DB01972
KEGG	hsa:1742

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Name: Morphine

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0248	Mi Ying Su Ke	蜜罂粟壳	Opium poppy	Papaver somniferum
H0757	Ying Su Ke	罂粟壳	Opium poppy pericarp	Papaver somniferum
H0756	Ying Su	罂粟	Opium poppy	Papaver somniferum