HIT-result

Target Description

Type	Detail
Target ID	T47YVM
Protein Name	Serine/threonine-protein kinase Sgk1
Uniprot ID	O00141
Protein Name Alias	EC 2.7.11.1; Serum/glucocorticoid-regulated kinase 1
Gene ID	6446
Gene Symbol	SGK1
Gene Alias	SGK
TTD	T64682: Clinical Trial target
Pfam	PF00433 ; PF00069
GO	0042127:regulation of cell population proliferation 0005634:nucleus 0017081:chloride channel regulator activity 0106311:protein threonine kinase activity 0017080:sodium channel regulator activity 0005829:cytosol 0007616:long-term memory 0008217:regulation of blood pressure 0005246:calcium channel regulator activity 1904045:cellular response to aldosterone 0006974:cellular response to DNA damage stimulus 0004712:protein serine/threonine/tyrosine kinase activity 0060453:regulation of gastric acid secretion 0032411:positive regulation of transporter activity 0016607:nuclear speck 0005654:nucleoplasm 0106310:protein serine kinase activity 0015459:potassium channel regulator activity 0048812:neuron projection morphogenesis 0005789:endoplasmic reticulum membrane 0006468:protein phosphorylation 0035556:intracellular signal transduction 0005524:ATP binding 0070294:renal sodium ion absorption 0034220:ion transmembrane transport 0006915:apoptotic process 0051090:regulation of DNA-binding transcription factor activity 0001558:regulation of cell growth 0004674:protein serine/threonine kinase activity 0050790:regulation of catalytic activity 0018105:peptidyl-serine phosphorylation 0006814:sodium ion transport 0030334:regulation of cell migration 1901796:regulation of signal transduction by p53 class mediator 0005886:plasma membrane 0042981:regulation of apoptotic process 0005737:cytoplasm 0005739:mitochondrion
PDB	3HDN ; 3HDM ; 2R5T
Drugbank	DB07837 ; DB03247 ; DB08191
KEGG	hsa:6446

Type

Detail

Target ID

T47YVM

Protein Name

Serine/threonine-protein kinase Sgk1

Uniprot ID

O00141

Protein Name Alias

EC 2.7.11.1; Serum/glucocorticoid-regulated kinase 1

Gene ID

6446

Gene Symbol

SGK1

Gene Alias

SGK

TTD

T64682: Clinical Trial target

Pfam

PF00433 ; PF00069

0042127:regulation of cell population proliferation

0005634:nucleus

0017081:chloride channel regulator activity

0106311:protein threonine kinase activity

0017080:sodium channel regulator activity

0005829:cytosol

0007616:long-term memory

0008217:regulation of blood pressure

0005246:calcium channel regulator activity

1904045:cellular response to aldosterone

0006974:cellular response to DNA damage stimulus

0004712:protein serine/threonine/tyrosine kinase activity

0060453:regulation of gastric acid secretion

0032411:positive regulation of transporter activity

0016607:nuclear speck

0005654:nucleoplasm

0106310:protein serine kinase activity

0015459:potassium channel regulator activity

0048812:neuron projection morphogenesis

0005789:endoplasmic reticulum membrane

0006468:protein phosphorylation

0035556:intracellular signal transduction

0005524:ATP binding

0070294:renal sodium ion absorption

0034220:ion transmembrane transport

0006915:apoptotic process

0051090:regulation of DNA-binding transcription factor activity

0001558:regulation of cell growth

0004674:protein serine/threonine kinase activity

0050790:regulation of catalytic activity

0018105:peptidyl-serine phosphorylation

0006814:sodium ion transport

0030334:regulation of cell migration

1901796:regulation of signal transduction by p53 class mediator

0005886:plasma membrane

0042981:regulation of apoptotic process

0005737:cytoplasm

0005739:mitochondrion

PDB

3HDN ; 3HDM ; 2R5T

Drugbank

DB07837 ; DB03247 ; DB08191

KEGG

hsa:6446

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0416	Shan Shen	山参	NA	Panax ginseng
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0757	Ying Su Ke	罂粟壳	Opium poppy pericarp	Papaver somniferum
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0248	Mi Ying Su Ke	蜜罂粟壳	Opium poppy	Papaver somniferum
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0756	Ying Su	罂粟	Opium poppy	Papaver somniferum
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0357	Ren Shen	人参	Ginseng	Panax ginseng

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 30)