Compound Description

ID:   C0868 Common name:   Aldosterone
IUPAC:  (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde CAS:  CAS:6251-69-0
Chembl ID:   CHEMBL273453 Pubchem ID:   CID:5839
Formula:  C21H28O5 TCM-ID:  TCMC649
Smiles:  OCC(=O)[C@H]1CC[C@@H]2[C@]1(C=O)C[C@H](O)[C@H]1[C@H]2CCC2=CC(=O)CC[C@]12C
Alias:

Pregn-4-ene-3,20-dione, 11β,18-epoxy-18,21-dihydroxy-;

(11β)-11,18-Epoxy-18,21-dihydroxypregn-4-ene-3,20-dione;

Aldosterone
Structure:

Related Targets  (Total: 35)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T88ER9 Serine/threonine-protein kinase D1PRKD1 Q15139
A 1 Reference(s)
T64F54 Mineralocorticoid receptorNR3C2 P08235
A 8 Reference(s)
T37WU9 Sodium/hydrogen exchanger 10SLC9C1 Q4G0N8
A 1 Reference(s)
T01KGS PendrinSLC26A4 O43511
A 2 Reference(s)
T37YKZ Endothelin receptor type BEDNRB P24530
A 1 Reference(s)
T28PHS Angiotensin-converting enzymeACE P12821
A 1 Reference(s)
T69WIB Solute carrier family 12 member 3SLC12A3 P55017
B 1 Reference(s)
T74QXI Serine/threonine-protein kinase mTORMTOR P42345
B 1 Reference(s)
T47YVM Serine/threonine-protein kinase Sgk1SGK1 O00141
B 1 Reference(s)
T36SOV Plasminogen activator inhibitor 1SERPINE1 P05121
C 3 Reference(s)
T23RWU Type-1 angiotensin II receptorAGTR1 P30556
C 2 Reference(s)
T02YDU Amiloride-sensitive sodium channel subunit gammaSCNN1G P51170
C 1 Reference(s)
T50VJF OsteopontinSPP1 P10451
C 1 Reference(s)
T37JN5 Neutrophil gelatinase-associated lipocalinLCN2 P80188
C 1 Reference(s)
T08Q1T Amiloride-sensitive sodium channel subunit alphaSCNN1A P37088
C 1 Reference(s)
T84XW5 Placenta growth factorPGF P49763
C 2 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
C 1 Reference(s)
T96EYH ProstasinPRSS8 Q16651
C 1 Reference(s)
T46J84 Nicotinamide phosphoribosyltransferaseNAMPT P43490
C 1 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
C 1 Reference(s)
T18LPB Cytochrome P450 11B2, mitochondrialCYP11B2 P19099
C 2 Reference(s)
T37V37 Prostaglandin-H2 D-isomerasePTGDS P41222
C 1 Reference(s)
T28HOM LeptinLEP P41159
C 1 Reference(s)
T80OPZ NADPH oxidase 4NOX4 Q9NPH5
C 1 Reference(s)
T82P0Z ReninREN P00797
C 1 Reference(s)
T10WQX Perilipin-1PLIN1 O60240
C 1 Reference(s)
T63YAO Caveolin-1CAV1 Q03135
C 1 Reference(s)
T62C0X Transcription factor MafAMAFA Q8NHW3
C 1 Reference(s)
T21S10 Heterogeneous nuclear ribonucleoproteins A2/B1HNRNPA2B1 P22626
C 1 Reference(s)
T43EQN Matrix Gla proteinMGP P08493
C 1 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
C 1 Reference(s)
T90XYZ C-reactive proteinCRP P02741
C 1 Reference(s)
T85E55 Serine/threonine-protein kinase Sgk2SGK2 Q9HBY8
C 1 Reference(s)
T20TB8 NADPH oxidase 1NOX1 Q9Y5S8
C 1 Reference(s)
T42XY2 Insulin-like growth factor 1 receptorIGF1R P08069
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 2)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens