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Target Description

Type Detail
Target ID T18LPB
Protein Name Cytochrome P450 11B2, mitochondrial
Uniprot ID P19099
Protein Name Alias Aldosterone synthase;  ALDOS;  Aldosterone-synthesizing enzyme;  CYPXIB2;  Corticosterone 18-monooxygenase, CYP11B2;  EC 1.14.15.5;  Cytochrome P-450Aldo;  Cytochrome P-450C18;  Steroid 11-beta-hydroxylase, CYP11B2;  EC 1.14.15.4;  Steroid 18-hydroxylase
Gene ID 1585
Gene Symbol CYP11B2
Gene Alias NA
TTD T59056: Research target
Pfam PF00067
GO
0006700:C21-steroid hormone biosynthetic process

0003091:renal water homeostasis

0016125:sterol metabolic process

0071375:cellular response to peptide hormone stimulus

0055075:potassium ion homeostasis

0034650:cortisol metabolic process

0004507:steroid 11-beta-monooxygenase activity

0008203:cholesterol metabolic process

0002017:regulation of blood volume by renal aldosterone

0034651:cortisol biosynthetic process

0006704:glucocorticoid biosynthetic process

0005506:iron ion binding

0047783:corticosterone 18-monooxygenase activity

0020037:heme binding

0005739:mitochondrion

0006705:mineralocorticoid biosynthetic process

0032870:cellular response to hormone stimulus

0032342:aldosterone biosynthetic process

0005743:mitochondrial inner membrane

0035865:cellular response to potassium ion

0055078:sodium ion homeostasis
PDB 4FDH ; 4ZGX ; 4DVQ ; 6XZ8 ; 6XZ9
Drugbank DB14545 ; DB01011 ; DB04630 ; DB00700 ; DB00741 ; DB14540 ; DB14543 ; DB11837 ; DB14539 ; DB06281 ; DB01388 ; DB14544 ; DB00421 ; DB00292
KEGG hsa:1585

Related Compounds  (Total: 3)

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C0110
Name: Glycyrrhizin
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C0868
Name: Aldosterone
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C0948
Name: aldosterone


Related Herbs  (Total: 18)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0472 Shu Da Huang熟大黄 NARheum palmatum
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis


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