Target Description

Type Detail
Target ID T88ER9
Protein Name Serine/threonine-protein kinase D1
Uniprot ID Q15139
Protein Name Alias EC 2.7.11.13;  Protein kinase C mu type;  Protein kinase D;  nPKC-D1;  nPKC-mu
Gene ID 5587
Gene Symbol PRKD1
Gene Alias PKD;  PKD1;  PRKCM
TTD T47885: Research target
Pfam PF00069 ; PF00169 ; PF00130
GO
0004674:protein serine/threonine kinase activity

0007399:nervous system development

0035556:intracellular signal transduction

0089700:protein kinase D signaling

0071447:cellular response to hydroperoxide

0034198:cellular response to amino acid starvation

0005524:ATP binding

0018107:peptidyl-threonine phosphorylation

0045669:positive regulation of osteoblast differentiation

0007229:integrin-mediated signaling pathway

0004697:protein kinase C activity

0035924:cellular response to vascular endothelial growth factor stimulus

0006468:protein phosphorylation

0001938:positive regulation of endothelial cell proliferation

0033138:positive regulation of peptidyl-serine phosphorylation

0007265:Ras protein signal transduction

0106311:protein threonine kinase activity

0018105:peptidyl-serine phosphorylation

0043536:positive regulation of blood vessel endothelial cell migration

0001525:angiogenesis

0046872:metal ion binding

0005829:cytosol

0042802:identical protein binding

0046777:protein autophosphorylation

0030154:cell differentiation

0010837:regulation of keratinocyte proliferation

0043552:positive regulation of phosphatidylinositol 3-kinase activity

0048010:vascular endothelial growth factor receptor signaling pathway

0006915:apoptotic process

0005794:Golgi apparatus

0005886:plasma membrane

0010508:positive regulation of autophagy

0045087:innate immune response

0005802:trans-Golgi network

2001044:regulation of integrin-mediated signaling pathway

2001028:positive regulation of endothelial cell chemotaxis

0004698:calcium-dependent protein kinase C activity

0048193:Golgi vesicle transport

0034599:cellular response to oxidative stress

0045766:positive regulation of angiogenesis

0038033:positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

0045944:positive regulation of transcription by RNA polymerase II

0060548:negative regulation of cell death

0030148:sphingolipid biosynthetic process

0032793:positive regulation of CREB transcription factor activity

0045806:negative regulation of endocytosis

0010976:positive regulation of neuron projection development

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0006954:inflammatory response

1901727:positive regulation of histone deacetylase activity

0106310:protein serine kinase activity

0007030:Golgi organization

0051092:positive regulation of NF-kappaB transcription factor activity

0007165:signal transduction

0031647:regulation of protein stability

0010595:positive regulation of endothelial cell migration

0016301:kinase activity

0000421:autophagosome membrane

PDB NA
Drugbank DB12010 ; DB11752
KEGG hsa:5587

Related Compounds  (Total: 3)

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C0363
Name: Resveratrol
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C0734
Name: Histamine
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C0868
Name: Aldosterone


Related Herbs  (Total: 28)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0006 Bai Qu Cai白屈菜 Greater celandineChelidonium majus
H0357 Ren Shen人参 GinsengPanax ginseng
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0416 Shan Shen山参 NAPanax ginseng
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba