Compound Description
| ID: C0734 | Common name: Histamine |
| IUPAC: 1,3-dimethylpyrazol-4-amine | CAS: CAS:51-45-6 |
| Chembl ID: NA | Pubchem ID: CID:4431056 |
| Formula: C5H9N3 | TCM-ID: TCMC4266 |
| Smiles: Cn1cc(c(n1)C)N | |
| Alias:
1H-Imidazole-4-ethanamine;
Histamine; 2-(1H-Imidazol-4-yl)ethanamine; 2-(1H-Imidazol-4-yl)ethylamine; 2-(1H-Imidazol-5-yl)ethanamine; 2-(1H-Imidazol-5-yl)ethylamine; 2-(3H-Imidazol-4-yl)ethylamine; 2-(4-Imidazolyl)ethanamine; 2-(4-Imidazolyl)ethylamine; 4-(2-Aminoethyl)imidazole; 5-Imidazoleethylamine; Eramin; Ergamine; Ergotidine; Imidazole-4-ethylamine; NSC 33792; β-Imidazolyl-4-ethylamine |
Structure:
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Related Targets (Total: 20)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T88AHJ | Histamine H3 receptor | HRH3 |
Q9Y5N1 |
A | 2 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
A | 2 Reference(s) |
| T90BQW | Sodium channel protein type 11 subunit alpha | SCN11A |
Q9UI33 |
A | 1 Reference(s) |
| T67KTV | Transient receptor potential cation channel subfamily V member 1 | TRPV1 |
Q8NER1 |
A | 1 Reference(s) |
| T76AZQ | Histidine decarboxylase | HDC |
P19113 |
B | 1 Reference(s) |
| T06N1B | Histamine H1 receptor | HRH1 |
P35367 |
C | 1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
C | 1 Reference(s) |
| T91OUC | Mucin-5AC | MUC5AC |
P98088 |
C | 1 Reference(s) |
| T31SX8 | Bone morphogenetic protein 2 | BMP2 |
P12643 |
C | 1 Reference(s) |
| T02RA6 | Protein disulfide-isomerase A6 | PDIA6 |
Q15084 |
C | 1 Reference(s) |
| T03G09 | Tumor necrosis factor ligand superfamily member 11 | TNFSF11 |
O14788 |
C | 1 Reference(s) |
| T49NJW | C-C motif chemokine 20 | CCL20 |
P78556 |
C | 1 Reference(s) |
| T60WNX | Vasopressin-neurophysin 2-copeptin | AVP |
P01185 |
C | 1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
C | 1 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
C | 1 Reference(s) |
| T00W4R | B1 bradykinin receptor | BDKRB1 |
P46663 |
C | 1 Reference(s) |
| T88ER9 | Serine/threonine-protein kinase D1 | PRKD1 |
Q15139 |
C | 1 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
C | 1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
C | 1 Reference(s) |
| T30AEN | Aquaporin-5 | AQP5 |
P55064 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 1)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0006 | Bai Qu Cai | 白屈菜 | Greater celandine | Chelidonium majus |
Ckey description of the interaction between compound and target