HIT-result

Target Description

Type	Detail
Target ID	T16KVU
Protein Name	Tumor necrosis factor receptor superfamily member 1A
Uniprot ID	P19438
Protein Name Alias	Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD antigen CD120a
Gene ID	7132
Gene Symbol	TNFRSF1A
Gene Alias	TNFAR; TNFR1
TTD	T86552: Clinical Trial target
Pfam	PF00531 ; PF00020
GO	0005615:extracellular space 0005031:tumor necrosis factor-activated receptor activity 0043120:tumor necrosis factor binding 0016020:membrane 0033209:tumor necrosis factor-mediated signaling pathway 0009986:cell surface 0008630:intrinsic apoptotic signaling pathway in response to DNA damage 2000304:positive regulation of ceramide biosynthetic process 0071260:cellular response to mechanical stimulus 0042742:defense response to bacterium 0042802:identical protein binding 0005576:extracellular region 0003332:negative regulation of extracellular matrix constituent secretion 0005886:plasma membrane 0010614:negative regulation of cardiac muscle hypertrophy 1902339:positive regulation of apoptotic process involved in morphogenesis 0002947:tumor necrosis factor receptor superfamily complex 0071550:death-inducing signaling complex assembly 0005887:integral component of plasma membrane 0007249:I-kappaB kinase/NF-kappaB signaling 0042531:positive regulation of tyrosine phosphorylation of STAT protein 0008625:extrinsic apoptotic signaling pathway via death domain receptors 0003177:pulmonary valve development 0072659:protein localization to plasma membrane 0005739:mitochondrion 0045944:positive regulation of transcription by RNA polymerase II 0043235:receptor complex 0050728:negative regulation of inflammatory response 0050729:positive regulation of inflammatory response 0019221:cytokine-mediated signaling pathway 0045121:membrane raft 0003176:aortic valve development 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0006954:inflammatory response 0000139:Golgi membrane 1903140:regulation of establishment of endothelial barrier 0006693:prostaglandin metabolic process 0010803:regulation of tumor necrosis factor-mediated signaling pathway 0016032:viral process
PDB	1ICH ; 7KP7 ; 7K7A ; 7KP8 ; 1TNR ; 7KPB ; 1EXT ; 1NCF ; 1FT4
Drugbank	DB11626 ; DB03507
KEGG	hsa:7132

Type

Detail

Target ID

T16KVU

Protein Name

Tumor necrosis factor receptor superfamily member 1A

Uniprot ID

P19438

Protein Name Alias

Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD antigen CD120a

Gene ID

7132

Gene Symbol

TNFRSF1A

Gene Alias

TNFAR; TNFR1

TTD

T86552: Clinical Trial target

Pfam

PF00531 ; PF00020

0005615:extracellular space

0005031:tumor necrosis factor-activated receptor activity

0043120:tumor necrosis factor binding

0016020:membrane

0033209:tumor necrosis factor-mediated signaling pathway

0009986:cell surface

0008630:intrinsic apoptotic signaling pathway in response to DNA damage

2000304:positive regulation of ceramide biosynthetic process

0071260:cellular response to mechanical stimulus

0042742:defense response to bacterium

0042802:identical protein binding

0005576:extracellular region

0003332:negative regulation of extracellular matrix constituent secretion

0005886:plasma membrane

0010614:negative regulation of cardiac muscle hypertrophy

1902339:positive regulation of apoptotic process involved in morphogenesis

0002947:tumor necrosis factor receptor superfamily complex

0071550:death-inducing signaling complex assembly

0005887:integral component of plasma membrane

0007249:I-kappaB kinase/NF-kappaB signaling

0042531:positive regulation of tyrosine phosphorylation of STAT protein

0008625:extrinsic apoptotic signaling pathway via death domain receptors

0003177:pulmonary valve development

0072659:protein localization to plasma membrane

0005739:mitochondrion

0045944:positive regulation of transcription by RNA polymerase II

0043235:receptor complex

0050728:negative regulation of inflammatory response

0050729:positive regulation of inflammatory response

0019221:cytokine-mediated signaling pathway

0045121:membrane raft

0003176:aortic valve development

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0006954:inflammatory response

0000139:Golgi membrane

1903140:regulation of establishment of endothelial barrier

0006693:prostaglandin metabolic process

0010803:regulation of tumor necrosis factor-mediated signaling pathway

0016032:viral process

PDB

1ICH ; 7KP7 ; 7K7A ; 7KP8 ; 1TNR ; 7KPB ; 1EXT ; 1NCF ; 1FT4

Drugbank

DB11626 ; DB03507

KEGG

hsa:7132

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0416	Shan Shen	山参	NA	Panax ginseng
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0919	Cui Yun Cao	翠云草	Hooked spikemoss	Selaginella uncinata
H0757	Ying Su Ke	罂粟壳	Opium poppy pericarp	Papaver somniferum
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0461	Shi Jun Zi Ren	使君子仁	NA	Combretum indicum
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0204	Ma Ren	麻仁	NA	Cannabis sativa
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0248	Mi Ying Su Ke	蜜罂粟壳	Opium poppy	Papaver somniferum
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0756	Ying Su	罂粟	Opium poppy	Papaver somniferum
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0003	Huo Ma Ren	火麻仁	Hemp fimble seed	Cannabis sativa
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0357	Ren Shen	人参	Ginseng	Panax ginseng

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 38)