HIT-result

Type	Detail
Target ID	T22V6A
Protein Name	Eukaryotic translation initiation factor 2-alpha kinase 3
Uniprot ID	Q9NZJ5
Protein Name Alias	EC 2.7.11.1; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK
Gene ID	9451
Gene Symbol	EIF2AK3
Gene Alias	PEK; PERK
TTD	T13176: Patented target
Pfam	PF00069
GO	0042802:identical protein binding 0046777:protein autophosphorylation 0034976:response to endoplasmic reticulum stress 0036492:eiF2alpha phosphorylation in response to endoplasmic reticulum stress 0004672:protein kinase activity 0106310:protein serine kinase activity 0017148:negative regulation of translation 0005789:endoplasmic reticulum membrane 0005829:cytosol 0004674:protein serine/threonine kinase activity 0031018:endocrine pancreas development 0106311:protein threonine kinase activity 0001503:ossification 1990737:response to manganese-induced endoplasmic reticulum stress 0030282:bone mineralization 0042149:cellular response to glucose starvation 1902235:regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 0004694:eukaryotic translation initiation factor 2alpha kinase activity 0018105:peptidyl-serine phosphorylation 0030176:integral component of endoplasmic reticulum membrane 0070417:cellular response to cold 0010628:positive regulation of gene expression 0005524:ATP binding 0005783:endoplasmic reticulum 0051879:Hsp90 protein binding 0048471:perinuclear region of cytoplasm 0019899:enzyme binding 0010998:regulation of translational initiation by eIF2 alpha phosphorylation 1900182:positive regulation of protein localization to nucleus 0034198:cellular response to amino acid starvation 0010575:positive regulation of vascular endothelial growth factor production 0006983:ER overload response 0016020:membrane 0030968:endoplasmic reticulum unfolded protein response 0060734:regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation 0036499:PERK-mediated unfolded protein response 0006468:protein phosphorylation 0002063:chondrocyte development 0005737:cytoplasm 0001525:angiogenesis 0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process 0007029:endoplasmic reticulum organization 0019722:calcium-mediated signaling 0032057:negative regulation of translational initiation in response to stress 0048009:insulin-like growth factor receptor signaling pathway 0045943:positive regulation of transcription by RNA polymerase I 0001501:skeletal system development 0019903:protein phosphatase binding 0031642:negative regulation of myelination
PDB	4X7O ; 4YZS ; 5SV7 ; 4X7N ; 4X7J ; 4G31 ; 4X7L ; 4G34 ; 4X7H ; 4M7I ; 4X7K
Drugbank	NA
KEGG	hsa:9451

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Name: Morphine

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0248	Mi Ying Su Ke	蜜罂粟壳	Opium poppy	Papaver somniferum
H0756	Ying Su	罂粟	Opium poppy	Papaver somniferum
H0757	Ying Su Ke	罂粟壳	Opium poppy pericarp	Papaver somniferum