HIT-result

Type	Detail
Target ID	T66YJ0
Protein Name	Mu-type opioid receptor
Uniprot ID	P35372
Protein Name Alias	M-OR-1; MOR-1; Mu opiate receptor; Mu opioid receptor; MOP; hMOP
Gene ID	4988
Gene Symbol	OPRM1
Gene Alias	MOR1
TTD	T47768: Successful target
Pfam	PF00001
GO	0060079:excitatory postsynaptic potential 0019904:protein domain specific binding 0031681:G-protein beta-subunit binding 0030424:axon 0001965:G-protein alpha-subunit binding 0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 0030425:dendrite 0080135:regulation of cellular response to stress 2000310:regulation of NMDA receptor activity 0031635:adenylate cyclase-inhibiting opioid receptor signaling pathway 0008022:protein C-terminus binding 0032496:response to lipopolysaccharide 0043951:negative regulation of cAMP-mediated signaling 0007186:G protein-coupled receptor signaling pathway 0042220:response to cocaine 0048149:behavioral response to ethanol 0032094:response to food 0008285:negative regulation of cell population proliferation 0005925:focal adhesion 0005245:voltage-gated calcium channel activity 0032590:dendrite membrane 0050769:positive regulation of neurogenesis 0061358:negative regulation of Wnt protein secretion 0042277:peptide binding 0002438:acute inflammatory response to antigenic stimulus 0032100:positive regulation of appetite 0005794:Golgi apparatus 0005886:plasma membrane 0042923:neuropeptide binding 0004930:G protein-coupled receptor activity 0007197:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway 0045019:negative regulation of nitric oxide biosynthetic process 0005768:endosome 0009314:response to radiation 0044849:estrous cycle 0043204:perikaryon 0007600:sensory perception 0043005:neuron projection 0042383:sarcolemma 0005887:integral component of plasma membrane 0004979:beta-endorphin receptor activity 0106072:negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 0038003:opioid receptor signaling pathway 0005783:endoplasmic reticulum 0031005:filamin binding 0043950:positive regulation of cAMP-mediated signaling 0070848:response to growth factor 0007218:neuropeptide signaling pathway 0042755:eating behavior 0038047:morphine receptor activity 0051481:negative regulation of cytosolic calcium ion concentration 0051930:regulation of sensory perception of pain 0019233:sensory perception of pain 0019221:cytokine-mediated signaling pathway 0045121:membrane raft 0070374:positive regulation of ERK1 and ERK2 cascade 0045429:positive regulation of nitric oxide biosynthetic process 0099056:integral component of presynaptic membrane 0042060:wound healing 0007200:phospholipase C-activating G protein-coupled receptor signaling pathway 0097444:spine apparatus 0099055:integral component of postsynaptic membrane 0007204:positive regulation of cytosolic calcium ion concentration 0032839:dendrite cytoplasm
PDB	NA
Drugbank	DB01466 ; DB01439 ; DB00497 ; DB01192 ; DB01227 ; DB00611 ; DB05492 ; DB00854 ; DB01183 ; DB00318 ; DB00844 ; DB09061 ; DB06738 ; DB09089 ; DB05046 ; DB11186 ; DB11691 ; DB00327 ; DB00504 ; DB01433 ; DB11130 ; DB00708 ; DB01535 ; DB09209 ; DB00193 ; DB00704 ; DB00333 ; DB01444 ; DB14881 ; DB06800 ; DB00913 ; DB09272 ; DB00802 ; DB06409 ; DB14011 ; DB01548 ; DB00647 ; DB00956 ; DB00921 ; DB06274 ; DB05509 ; DB00899 ; DB00321 ; DB06230 ; DB06204 ; DB01497 ; DB09049 ; DB09173 ; DB01565 ; DB01452 ; DB14009 ; DB12668 ; DB01081 ; DB00836 ; DB00454 ; DB01221 ; DB00295 ; DB00652 ; DB09289 ; DB00904 ; DB01238 ; DB01571 ; DB00813 ; DB01209 ; DB00514 ; DB14146
KEGG	hsa:4988

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Name: Morphine

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Name: Naloxone

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Name: Oxycodone

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Name: S-Adenosyl Methionine

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Name: lobeline

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Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0248	Mi Ying Su Ke	蜜罂粟壳	Opium poppy	Papaver somniferum
H0757	Ying Su Ke	罂粟壳	Opium poppy pericarp	Papaver somniferum
H0756	Ying Su	罂粟	Opium poppy	Papaver somniferum
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens