HIT-result

Type	Detail
Target ID	T66YJ0
Protein Name	Mu-type opioid receptor
Uniprot ID	P35372
Protein Name Alias	M-OR-1; MOR-1; Mu opiate receptor; Mu opioid receptor; MOP; hMOP
Gene ID	4988
Gene Symbol	OPRM1
Gene Alias	MOR1
TTD	T47768: Successful target
Pfam	PF00001
GO	0060079:excitatory postsynaptic potential 0019904:protein domain specific binding 0031681:G-protein beta-subunit binding 0030424:axon 0001965:G-protein alpha-subunit binding 0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 0030425:dendrite 0080135:regulation of cellular response to stress 2000310:regulation of NMDA receptor activity 0031635:adenylate cyclase-inhibiting opioid receptor signaling pathway 0008022:protein C-terminus binding 0032496:response to lipopolysaccharide 0043951:negative regulation of cAMP-mediated signaling 0007186:G protein-coupled receptor signaling pathway 0042220:response to cocaine 0048149:behavioral response to ethanol 0032094:response to food 0008285:negative regulation of cell population proliferation 0005925:focal adhesion 0005245:voltage-gated calcium channel activity 0032590:dendrite membrane 0050769:positive regulation of neurogenesis 0061358:negative regulation of Wnt protein secretion 0042277:peptide binding 0002438:acute inflammatory response to antigenic stimulus 0032100:positive regulation of appetite 0005794:Golgi apparatus 0005886:plasma membrane 0042923:neuropeptide binding 0004930:G protein-coupled receptor activity 0007197:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway 0045019:negative regulation of nitric oxide biosynthetic process 0005768:endosome 0009314:response to radiation 0044849:estrous cycle 0043204:perikaryon 0007600:sensory perception 0043005:neuron projection 0042383:sarcolemma 0005887:integral component of plasma membrane 0004979:beta-endorphin receptor activity 0106072:negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 0038003:opioid receptor signaling pathway 0005783:endoplasmic reticulum 0031005:filamin binding 0043950:positive regulation of cAMP-mediated signaling 0070848:response to growth factor 0007218:neuropeptide signaling pathway 0042755:eating behavior 0038047:morphine receptor activity 0051481:negative regulation of cytosolic calcium ion concentration 0051930:regulation of sensory perception of pain 0019233:sensory perception of pain 0019221:cytokine-mediated signaling pathway 0045121:membrane raft 0070374:positive regulation of ERK1 and ERK2 cascade 0045429:positive regulation of nitric oxide biosynthetic process 0099056:integral component of presynaptic membrane 0042060:wound healing 0007200:phospholipase C-activating G protein-coupled receptor signaling pathway 0097444:spine apparatus 0099055:integral component of postsynaptic membrane 0007204:positive regulation of cytosolic calcium ion concentration 0032839:dendrite cytoplasm
PDB	NA
Drugbank	DB01466 ; DB01439 ; DB00497 ; DB01192 ; DB01227 ; DB00611 ; DB05492 ; DB00854 ; DB01183 ; DB00318 ; DB00844 ; DB09061 ; DB06738 ; DB09089 ; DB05046 ; DB11186 ; DB11691 ; DB00327 ; DB00504 ; DB01433 ; DB11130 ; DB00708 ; DB01535 ; DB09209 ; DB00193 ; DB00704 ; DB00333 ; DB01444 ; DB14881 ; DB06800 ; DB00913 ; DB09272 ; DB00802 ; DB06409 ; DB14011 ; DB01548 ; DB00647 ; DB00956 ; DB00921 ; DB06274 ; DB05509 ; DB00899 ; DB00321 ; DB06230 ; DB06204 ; DB01497 ; DB09049 ; DB09173 ; DB01565 ; DB01452 ; DB14009 ; DB12668 ; DB01081 ; DB00836 ; DB00454 ; DB01221 ; DB00295 ; DB00652 ; DB09289 ; DB00904 ; DB01238 ; DB01571 ; DB00813 ; DB01209 ; DB00514 ; DB14146
KEGG	hsa:4988

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Name: Morphine

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Name: Naloxone

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Name: Oxycodone

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Name: S-Adenosyl Methionine

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Name: lobeline

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