Compound Description
| ID: C0236 | Common name: Naloxone |
| IUPAC: (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one | CAS: CAS:465-65-6 |
| Chembl ID: CHEMBL80 | Pubchem ID: CID:5284596 |
| Formula: C19H21NO4 | TCM-ID: TCMC1724 |
| Smiles: C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O | |
| Alias:
Morphinan-6-one, 17-allyl-4,5α-epoxy-3,14-dihydroxy-;
Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5α)-; Normorphinone, N-allyl-7,8-dihydro-14-hydroxy-; (5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propen-1-yl)morphinan-6-one; (-)-Naloxone; 12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro[4,5-bcd]furan-5(6H)-one; NSC 70413; Naloxone; l-Naloxone |
Structure:
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Related Targets (Total: 5)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T66YJ0 | Mu-type opioid receptor | OPRM1 |
P35372 |
A | 5 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
A | 2 Reference(s) |
| T43DMF | Kappa-type opioid receptor | OPRK1 |
P41145 |
A | 1 Reference(s) |
| T28Z4N | Hepatitis A virus cellular receptor 1 | HAVCR1 |
Q96D42 |
C | 1 Reference(s) |
| T30VNV | Myeloperoxidase | MPO |
P05164 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 3)
Ckey description of the interaction between compound and target