Target Description

Type Detail
Target ID T86CQC
Protein Name Glutamate receptor ionotropic, NMDA 1
Uniprot ID Q05586
Protein Name Alias GluN1
Gene ID 2902
Gene Symbol GRIN1
Gene Alias NMDAR1
TTD T62276: Successful target
Pfam PF01094 ; PF10562 ; PF00060 ; PF10613
GO
0060079:excitatory postsynaptic potential

0042165:neurotransmitter binding

0000165:MAPK cascade

0005789:endoplasmic reticulum membrane

0043083:synaptic cleft

0055074:calcium ion homeostasis

0030425:dendrite

0007268:chemical synaptic transmission

0038023:signaling receptor activity

2000310:regulation of NMDA receptor activity

0043197:dendritic spine

0017146:NMDA selective glutamate receptor complex

0009986:cell surface

0007420:brain development

2000463:positive regulation of excitatory postsynaptic potential

0097553:calcium ion transmembrane import into cytosol

2001056:positive regulation of cysteine-type endopeptidase activity

0060076:excitatory synapse

0043195:terminal bouton

0051290:protein heterotetramerization

0022849:glutamate-gated calcium ion channel activity

0005516:calmodulin binding

0015276:ligand-gated ion channel activity

0044877:protein-containing complex binding

0097060:synaptic membrane

0010524:positive regulation of calcium ion transport into cytosol

0045202:synapse

0005886:plasma membrane

0042391:regulation of membrane potential

0043005:neuron projection

0005887:integral component of plasma membrane

0016595:glutamate binding

0005737:cytoplasm

1905429:response to glycine

0035235:ionotropic glutamate receptor signaling pathway

0048167:regulation of synaptic plasticity

0045944:positive regulation of transcription by RNA polymerase II

0048013:ephrin receptor signaling pathway

0045211:postsynaptic membrane

0006812:cation transport

0005509:calcium ion binding

0004972:NMDA glutamate receptor activity

0018964:propylene metabolic process

0098976:excitatory chemical synaptic transmission

0014069:postsynaptic density

1903428:positive regulation of reactive oxygen species biosynthetic process

0008542:visual learning

0008021:synaptic vesicle

0045471:response to ethanol

0001540:amyloid-beta binding

0016594:glycine binding

PDB 6IRA ; 5H8F ; 6IRG ; 6IRF ; 5H8N ; 5TP9 ; 3BYA ; 5I2N ; 5KCJ ; 5KDT ; 5I2K ; 6IRH ; 2NR1 ; 5TPA ; 2HQW ; 5H8Q ; 5H8H
Drugbank DB00418 ; DB06151 ; DB08838 ; DB01174 ; DB06738 ; DB06741 ; DB03929 ; DB00193 ; DB00659 ; DB04896 ; DB00333 ; DB01708 ; DB01173 ; DB00843 ; DB08954 ; DB00289 ; DB01043 ; DB09409 ; DB00312 ; DB11823 ; DB04620 ; DB13146 ; DB05824 ; DB00142 ; DB09481 ; DB00874 ; DB00454 ; DB01238 ; DB00228 ; DB01931
KEGG hsa:2902

Related Compounds  (Total: 11)

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C0055
Name: Estradiol
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C0139
Name: Ifenprodil
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C0226
Name: Morphine
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C0370
Name: Rhynchophylline
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C0406
Name: Simvastatin


Related Herbs  (Total: 77)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0722 Yang Nai Nai Ye羊奶奶叶 NAElaeagnus pungens
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H0416 Shan Shen山参 NAPanax ginseng
H0356 Ren Gong She Xiang人工麝香 AbelmuskMoschus moschiferus
H0077 Jiu EthanolVinum
H0423 Shan Zha Ye山楂叶 NACrataegi folium
H1220 Hua Xiang Shu Guo化香树果 NAPlatycarya strobilacea
H0327 Qian Li Guang千里光 Climbing groundselSenecio scandens
H1246 Huang Pi Ye黄皮叶 Chinese wampee leafClausena lansium
H0277 Nan Ban Lan Gen南板蓝根 Indigowoad rootBaphicacanthus cusia
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H1211 Bai Mei白眉 pilose gerbera herbGerbera piloselloides
H0989 Ding Kui Cao丁葵草 Herb of twinleaf zorniaKummerowia striata
H1210 Hu Tui Zi Ye胡颓子叶 NAElaeagnus pungens
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0357 Ren Shen人参 GinsengPanax ginseng
H0705 Yan Hu Lu Ba盐胡芦巴 FenugreekTrigonella foenum-graecum
H0361 Ren Zi Cao人字草 Herb of twinleaf zorniaKummerowia striata
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H0899 Chui Pen Cao Qing Gao垂盆草清膏 all - grass of stringy stonecropSedum sarmentosum
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0837 Zhu Ye竹叶 Bamboo leavesPhyllostachys nigra
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H0898 Chui Pen Cao垂盆草 all - grass of stringy stonecropSedum sarmentosum
H0236 Mao She Xiang Jin Gao毛麝香浸膏 AbelmuskMoschus moschiferus
H0217 Man Jing Zi蔓荆子 Threeleaf chastetree fruitVitex trifolia
H0524 Tan Xiang檀香 SandalwoodSantalum album
H0337 Qin Jiao Hua秦艽花 large-leaved gentian flowerGentiana straminea
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H1099 Gou Teng钩藤 Sharpleaf gambirplantUncaria rhynchophylla
H0188 Lv Cao葎草 Japanese hopHumulus japonicus
H0278 Nan Ban Lan Gen Jin Gao Fen南板蓝根浸膏粉 Indigowoad rootBaphicacanthus cusia
H0034 Jiao Gu Lan绞股蓝 Fiveleaf gynostemmaGynostemma pentaphyllum
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0336 Qin Jiao秦艽 large-leaved gentianGentiana macrophylla
H0437 She Xiang麝香 AbelmuskMoschus moschiferus
H1221 Hua Xiang Shu Guo Xu化香树果序 NAPlatycarya strobilacea
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0668 Xiao Ye Huang Yang小叶黄杨 Small-leaved boxBuxus microphylla
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0216 Man Jing Ye蔓荆叶 Threeleaf chastetree leafVitex trifolia
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0985 Dian Zhu Ye滇竹叶 Bamboo leavesPhyllostachys nigra
H0235 Mao She Xiang毛麝香 AbelmuskMoschus moschiferus
H0757 Ying Su Ke罂粟壳 Opium poppy pericarpPapaver somniferum
H0661 Xiao Hei Dou小黑豆 Black turtle beanPhaseolus vulgaris
H0233 Mao Liang Mian Zhen毛两面针 NAZanthoxylum nitidum
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0954 Dan Zhu Ye淡竹叶 Common lophatherumLophatherum gracile
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0764 Yu Xing Cao鱼腥草 Heartleaf houttuyniaHouttuynia cordata
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H0468 Shi Wei石韦 Japanese felt fern frondPyrrosia lingua
H0552 Tie Sao Zhou铁扫帚 Sericea lespedezaLespedeza cuneata
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H0229 Mao Da Ding Cao毛大丁草 Pilose gerberaGerbera piloselloides
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H0020 Ji Yan Cao鸡眼草 Striate kummerowiaKummerowia striata
H0520 Tai Pan Fen胎盘粉 Fetus powderHuman placenta
H0521 Tai Pan Zu Zhi Fen胎盘组织粉 NAHuman placenta
H0248 Mi Ying Su Ke蜜罂粟壳 Opium poppyPapaver somniferum
H0204 Ma Ren麻仁 NACannabis sativa
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H0756 Ying Su罂粟 Opium poppyPapaver somniferum