HIT-result

Type	Detail
Target ID	T88ENR
Protein Name	Beta-arrestin-1
Uniprot ID	P49407
Protein Name Alias	Arrestin beta-1; Non-visual arrestin-2
Gene ID	408
Gene Symbol	ARRB1
Gene Alias	ARR1
TTD	T41646: Research target
Pfam	PF00339 ; PF02752
GO	0030168:platelet activation 0016573:histone acetylation 0035615:clathrin adaptor activity 0031625:ubiquitin protein ligase binding 0090240:positive regulation of histone H4 acetylation 0042493:response to drug 0031691:alpha-1A adrenergic receptor binding 0031896:V2 vasopressin receptor binding 0042699:follicle-stimulating hormone signaling pathway 0043197:dendritic spine 0031701:angiotensin receptor binding 1990763:arrestin family protein binding 0061024:membrane organization 0008134:transcription factor binding 0001934:positive regulation of protein phosphorylation 0006892:post-Golgi vesicle-mediated transport 0007186:G protein-coupled receptor signaling pathway 0031692:alpha-1B adrenergic receptor binding 0003713:transcription coactivator activity 0032715:negative regulation of interleukin-6 production 0016323:basolateral plasma membrane 0035612:AP-2 adaptor complex binding 0016604:nuclear body 0005096:GTPase activator activity 0070373:negative regulation of ERK1 and ERK2 cascade 0005829:cytosol 0045309:protein phosphorylated amino acid binding 0032088:negative regulation of NF-kappaB transcription factor activity 0031397:negative regulation of protein ubiquitination 0035066:positive regulation of histone acetylation 0032717:negative regulation of interleukin-8 production 0035025:positive regulation of Rho protein signal transduction 0005886:plasma membrane 0005765:lysosomal membrane 0043149:stress fiber assembly 0005768:endosome 0031762:follicle-stimulating hormone receptor binding 0005654:nucleoplasm 0030659:cytoplasmic vesicle membrane 0001664:G protein-coupled receptor binding 0044325:ion channel binding 0045746:negative regulation of Notch signaling pathway 0043161:proteasome-mediated ubiquitin-dependent protein catabolic process 0005737:cytoplasm 0004857:enzyme inhibitor activity 0031143:pseudopodium 0031398:positive regulation of protein ubiquitination 0006511:ubiquitin-dependent protein catabolic process 0034393:positive regulation of smooth muscle cell apoptotic process 0045944:positive regulation of transcription by RNA polymerase II 0030331:estrogen receptor binding 0034260:negative regulation of GTPase activity 0045211:postsynaptic membrane 0005634:nucleus 0008284:positive regulation of cell population proliferation 0002092:positive regulation of receptor internalization 0005905:clathrin-coated pit 0070374:positive regulation of ERK1 and ERK2 cascade 0043524:negative regulation of neuron apoptotic process 0015031:protein transport 0005159:insulin-like growth factor receptor binding 0016567:protein ubiquitination 0014069:postsynaptic density 0000139:Golgi membrane 0000785:chromatin 0000187:activation of MAPK activity 0002031:G protein-coupled receptor internalization 0001933:negative regulation of protein phosphorylation 0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 0031410:cytoplasmic vesicle 0006357:regulation of transcription by RNA polymerase II
PDB	6UP7 ; 6PWC ; 6TKO ; 2IV8
Drugbank	NA
KEGG	hsa:408

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Name: Morphine

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0248	Mi Ying Su Ke	蜜罂粟壳	Opium poppy	Papaver somniferum
H0756	Ying Su	罂粟	Opium poppy	Papaver somniferum
H0757	Ying Su Ke	罂粟壳	Opium poppy pericarp	Papaver somniferum