HIT-result

Target Description

Type	Detail
Target ID	T73WJH
Protein Name	Calcium/calmodulin-dependent protein kinase kinase 2
Uniprot ID	Q96RR4
Protein Name Alias	CaM-KK 2; CaM-kinase kinase 2; CaMKK 2; EC 2.7.11.17; Calcium/calmodulin-dependent protein kinase kinase beta; CaM-KK beta; CaM-kinase kinase beta; CaMKK beta
Gene ID	10645
Gene Symbol	CAMKK2
Gene Alias	CAMKKB; KIAA0787
TTD	T82262: Patented target
Pfam	PF00069
GO	0004713:protein tyrosine kinase activity 0000165:MAPK cascade 0005524:ATP binding 0007268:chemical synaptic transmission 0006468:protein phosphorylation 0106311:protein threonine kinase activity 0001934:positive regulation of protein phosphorylation 0005829:cytosol 0046777:protein autophosphorylation 0005516:calmodulin binding 0004683:calmodulin-dependent protein kinase activity 0005654:nucleoplasm 0043005:neuron projection 0045893:positive regulation of transcription, DNA-templated 0045859:regulation of protein kinase activity 1903599:positive regulation of autophagy of mitochondrion 0005509:calcium ion binding 0106310:protein serine kinase activity 0061762:CAMKK-AMPK signaling cascade 0019722:calcium-mediated signaling 0034614:cellular response to reactive oxygen species
PDB	6BQQ ; 6Y3O ; 6EF5 ; 5VT1 ; 6Y8A ; 2ZV2 ; 6FEL ; 6BRC ; 5YV8 ; 6BQP ; 5YV9 ; 6EWW ; 6BKU ; 5UYJ ; 6BQL ; 6CMJ ; 5YVB ; 6BLE ; 5YVC ; 5UY6 ; 5YVA
Drugbank	DB12010
KEGG	hsa:10645

Type

Detail

Target ID

T73WJH

Protein Name

Calcium/calmodulin-dependent protein kinase kinase 2

Uniprot ID

Q96RR4

Protein Name Alias

CaM-KK 2; CaM-kinase kinase 2; CaMKK 2; EC 2.7.11.17; Calcium/calmodulin-dependent protein kinase kinase beta; CaM-KK beta; CaM-kinase kinase beta; CaMKK beta

Gene ID

10645

Gene Symbol

CAMKK2

Gene Alias

CAMKKB; KIAA0787

TTD

T82262: Patented target

Pfam

PF00069

0004713:protein tyrosine kinase activity

0000165:MAPK cascade

0005524:ATP binding

0007268:chemical synaptic transmission

0006468:protein phosphorylation

0106311:protein threonine kinase activity

0001934:positive regulation of protein phosphorylation

0005829:cytosol

0046777:protein autophosphorylation

0005516:calmodulin binding

0004683:calmodulin-dependent protein kinase activity

0005654:nucleoplasm

0043005:neuron projection

0045893:positive regulation of transcription, DNA-templated

0045859:regulation of protein kinase activity

1903599:positive regulation of autophagy of mitochondrion

0005509:calcium ion binding

0106310:protein serine kinase activity

0061762:CAMKK-AMPK signaling cascade

0019722:calcium-mediated signaling

0034614:cellular response to reactive oxygen species

PDB

6BQQ ; 6Y3O ; 6EF5 ; 5VT1 ; 6Y8A ; 2ZV2 ; 6FEL ; 6BRC ; 5YV8 ; 6BQP ; 5YV9 ; 6EWW ; 6BKU ; 5UYJ ; 6BQL ; 6CMJ ; 5YVB ; 6BLE ; 5YVC ; 5UY6 ; 5YVA

Drugbank

DB12010

KEGG

hsa:10645

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Name: Morphine

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Name: (+/-)Nicotine

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Name: cocaine

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Name: Cholecalciferol

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0925	Da Fu Zi	大腹子	Areca palm	Areca catechu
H0757	Ying Su Ke	罂粟壳	Opium poppy pericarp	Papaver somniferum
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0958	Dang Shen	党参	Pilose asiabell	Codonopsis pilosula
H0960	Dang Shen Qing Gao	党参清膏	Root of hairy asiabell	Codonopsis pilosula
H0275	Mu Zei	木贼	Common scouring rush	Equisetum hiemale
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0248	Mi Ying Su Ke	蜜罂粟壳	Opium poppy	Papaver somniferum
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H0756	Ying Su	罂粟	Opium poppy	Papaver somniferum
H0258	Mo Han Lian	墨旱莲	Yerbadetajo	Eclipta prostrata
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 14)