Compound Description
| ID: C0639 | Common name: (+/-)Nicotine |
| IUPAC: 3-(1-methylpyrrolidin-2-yl)pyridine | CAS: NA |
| Chembl ID: CHEMBL440464 | Pubchem ID: CID:942 |
| Formula: C10H14N2 | TCM-ID: TCMC34 |
| Smiles: CN1CCCC1C2=CN=CC=C2 | |
| Alias:
NA
|
Structure:
|
Related Targets (Total: 74)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T34I45 | Neuronal acetylcholine receptor subunit alpha-7 | CHRNA7 |
P36544 |
A | 1 Reference(s) |
| T16A2X | Catalase | CAT |
P04040 |
A | 1 Reference(s) |
| T70HTD | Cytochrome P450 2E1 | CYP2E1 |
P05181 |
A | 1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
A | 1 Reference(s) |
| T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
C | 1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
C | 1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
C | 1 Reference(s) |
| T42O1D | Delta-type opioid receptor | OPRD1 |
P41143 |
C | 1 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
C | 1 Reference(s) |
| T76B0A | Gap junction alpha-1 protein | GJA1 |
P17302 |
C | 1 Reference(s) |
| T30D9G | Superoxide dismutase [Cu-Zn] | SOD1 |
P00441 |
C | 1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
C | 1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
C | 1 Reference(s) |
| T85IZ0 | Opioid-binding protein/cell adhesion molecule | OPCML |
Q14982 |
C | 1 Reference(s) |
| T95IYZ | Adiponectin | ADIPOQ |
Q15848 |
C | 1 Reference(s) |
| T04WT7 | Fibronectin | FN1 |
P02751 |
C | 1 Reference(s) |
| T52GFD | Neuronal acetylcholine receptor subunit alpha-6 | CHRNA6 |
Q15825 |
C | 1 Reference(s) |
| T78IOY | Telomerase reverse transcriptase | TERT |
O14746 |
C | 1 Reference(s) |
| T23TJV | Tyrosine 3-monooxygenase | TH |
P07101 |
C | 1 Reference(s) |
| T78KL2 | Collagen alpha-1(III) chain | COL3A1 |
P02461 |
C | 1 Reference(s) |
| T56TXY | Polyunsaturated fatty acid 5-lipoxygenase | ALOX5 |
P09917 |
C | 1 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
C | 1 Reference(s) |
| T15VAS | Integrin beta-1 | ITGB1 |
P05556 |
C | 1 Reference(s) |
| T27LA6 | DNA | DNMT1 |
P26358 |
C | 1 Reference(s) |
| T64V6C | Glutamate decarboxylase 1 | GAD1 |
Q99259 |
C | 1 Reference(s) |
| T25H22 | Protein kinase C beta type | PRKCB |
P05771 |
C | 1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
C | 1 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
C | 1 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
C | 1 Reference(s) |
| T02DYS | Protein fosB | FOSB |
P53539 |
C | 1 Reference(s) |
| T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
C | 1 Reference(s) |
| T17CZC | Tissue factor | F3 |
P13726 |
C | 1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
C | 1 Reference(s) |
| T14LSK | E3 ubiquitin-protein ligase XIAP | XIAP |
P98170 |
C | 1 Reference(s) |
| T36B1Q | Baculoviral IAP repeat-containing protein 5 | BIRC5 |
O15392 |
C | 1 Reference(s) |
| T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
C | 1 Reference(s) |
| T32IXS | Integrin alpha-M | ITGAM |
P11215 |
C | 1 Reference(s) |
| T91F6Z | Integrin alpha-L | ITGAL |
P20701 |
C | 1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
C | 1 Reference(s) |
| T25C2G | Nuclear receptor subfamily 4 group A member 1 | NR4A1 |
P22736 |
C | 1 Reference(s) |
| T37ADS | Early growth response protein 1 | EGR1 |
P18146 |
C | 1 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
C | 1 Reference(s) |
| T69NG6 | Interleukin-10 | IL10 |
P22301 |
C | 1 Reference(s) |
| T62P0D | Collagenase 3 | MMP13 |
P45452 |
C | 1 Reference(s) |
| T20H9F | Stromelysin-1 | MMP3 |
P08254 |
C | 1 Reference(s) |
| T03O7G | Orexin | HCRT |
O43612 |
C | 1 Reference(s) |
| T82RFG | P2Y purinoceptor 12 | P2RY12 |
Q9H244 |
C | 1 Reference(s) |
| T73WJH | Calcium/calmodulin-dependent protein kinase kinase 2 | CAMKK2 |
Q96RR4 |
C | 1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
C | 1 Reference(s) |
| T45G32 | Proto-oncogene tyrosine-protein kinase Src | SRC |
P12931 |
C | 1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
C | 1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
C | 1 Reference(s) |
| T01P7T | Retinoic acid receptor RXR-beta | RXRB |
P28702 |
C | 1 Reference(s) |
| T02P7Q | Dihydrofolate reductase | DHFR |
P00374 |
C | 1 Reference(s) |
| T75OVL | High affinity nerve growth factor receptor | NTRK1 |
P04629 |
C | 2 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
C | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
C | 1 Reference(s) |
| T00EP2 | Tissue-type plasminogen activator | PLAT |
P00750 |
C | 1 Reference(s) |
| T31P1D | Metalloproteinase inhibitor 1 | TIMP1 |
P01033 |
C | 1 Reference(s) |
| T85AB0 | Metalloproteinase inhibitor 4 | TIMP4 |
Q99727 |
C | 1 Reference(s) |
| T85HMF | Metalloproteinase inhibitor 3 | TIMP3 |
P35625 |
C | 1 Reference(s) |
| T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
C | 1 Reference(s) |
| T80OJF | Interstitial collagenase | MMP1 |
P03956 |
C | 1 Reference(s) |
| T64T6J | Beta-1 adrenergic receptor | ADRB1 |
P08588 |
C | 1 Reference(s) |
| T63M1G | Integrin alpha-2 | ITGA2 |
P17301 |
C | 1 Reference(s) |
| T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
C | 1 Reference(s) |
| T01E8J | Amyloid-beta precursor protein | APP |
P05067 |
C | 1 Reference(s) |
| T56G7O | Acyl-CoA-binding protein | DBI |
P07108 |
C | 1 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
C | 1 Reference(s) |
| T28HOM | Leptin | LEP |
P41159 |
C | 1 Reference(s) |
| T24U57 | E-selectin | SELE |
P16581 |
C | 1 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
C | 1 Reference(s) |
| T13HLX | cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) | PDE4B |
Q07343 |
C | 1 Reference(s) |
| T18CPB | Choline O-acetyltransferase | CHAT |
P28329 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 11)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0408 | Bing Lang | 槟榔 | Betenutpalm | Areca catechu |
| H0960 | Dang Shen Qing Gao | 党参清膏 | Root of hairy asiabell | Codonopsis pilosula |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H1077 | Bai Hu Jiao | 白胡椒 | white pepper | Piper nigrum |
| H0258 | Mo Han Lian | 墨旱莲 | Yerbadetajo | Eclipta prostrata |
| H0958 | Dang Shen | 党参 | Pilose asiabell | Codonopsis pilosula |
| H0925 | Da Fu Zi | 大腹子 | Areca palm | Areca catechu |
| H1204 | Hu Jiao | 胡椒 | Black pepper | Piper nigrum |
| H1176 | Hei Hu Jiao | 黑胡椒 | Black pepper | Piper nigrum |
| H0275 | Mu Zei | 木贼 | Common scouring rush | Equisetum hiemale |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
Ckey description of the interaction between compound and target