Target Description

Type Detail
Target ID T02P7Q
Protein Name Dihydrofolate reductase
Uniprot ID P00374
Protein Name Alias EC 1.5.1.3
Gene ID 1719
Gene Symbol DHFR
Gene Alias NA
TTD T17345: Successful target
Pfam PF00186
GO
0046653:tetrahydrofolate metabolic process

0005829:cytosol

0050661:NADP binding

0017148:negative regulation of translation

0006545:glycine biosynthetic process

0046654:tetrahydrofolate biosynthetic process

1990825:sequence-specific mRNA binding

0005542:folic acid binding

0008144:drug binding

0000900:translation repressor activity, mRNA regulatory element binding

0051870:methotrexate binding

0000083:regulation of transcription involved in G1/S transition of mitotic cell cycle

0051000:positive regulation of nitric-oxide synthase activity

0046655:folic acid metabolic process

2000121:regulation of removal of superoxide radicals

0031427:response to methotrexate

0031103:axon regeneration

0006729:tetrahydrobiopterin biosynthetic process

0003729:mRNA binding

0006730:one-carbon metabolic process

0070402:NADPH binding

0046452:dihydrofolate metabolic process

0004146:dihydrofolate reductase activity

0005739:mitochondrion

PDB 3NTZ ; 6DAV ; 5HSR ; 1HFQ ; 2C2S ; 1HFR ; 4M6J ; 1DHF ; 2W3B ; 5HT5 ; 1OHJ ; 1S3W ; 2W3A ; 3L3R ; 3EIG ; 3FS6 ; 4QHV ; 1BOZ ; 3N0H ; 1YHO ; 5HSU ; 2C2T ; 3GI2 ; 3NU0 ; 4KD7 ; 1S3V ; 3NZD ; 1PD8 ; 3NXX ; 3NXR ; 1DRF ; 4KFJ ; 1PDB ; 3NXV ; 6VCJ ; 1OHK ; 1MVT ; 1MVS ; 5HUI ; 3GHC ; 1U72 ; 5HVB ; 1DLS ; 1KMS ; 3OAF ; 4M6K ; 6A7E ; 4QJC ; 3F8Z ; 3F91 ; 3S7A ; 3F8Y ; 4DDR ; 4KAK ; 4KEB ; 5HT4 ; 4G95 ; 3GHW ; 3GHV ; 3GYF ; 1S3U ; 2DHF ; 6DE4 ; 3S3V ; 3NXT ; 1HFP ; 5HQY ; 3NXO ; 5HVE ; 2W3M ; 6A7C ; 5HPB ; 4M6L ; 1DLR ; 1PD9 ; 3NXY ; 1U71 ; 4KBN ; 1KMV ; 5HQZ
Drugbank DB08878 ; DB03987 ; DB06813 ; DB07141 ; DB01157 ; DB03886 ; DB07142 ; DB08642 ; DB00158 ; DB03351 ; DB00205 ; DB06358 ; DB00563 ; DB03461 ; DB08406 ; DB02583 ; DB00642 ; DB03695 ; DB01131 ; DB02559 ; DB00555 ; DB02104 ; DB00157 ; DB03060 ; DB08448 ; DB07140 ; DB00798 ; DB02919 ; DB07144 ; DB03125 ; DB02427 ; DB08234
KEGG hsa:1719

Related Compounds  (Total: 5)

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C0388
Name: Sanguinarium
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C0639
Name: (+/-)Nicotine
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C0840
Name: Sanguinarine
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C1163
Name: Benzamide
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C1241
Name: Cianidanol


Related Herbs  (Total: 149)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H0698 Ya Zao牙皂 Chinese honeylocust abnormal fruitGleditsia sinensis
H1162 Hang Shao杭芍 White peony rootPaeonia albiflora
H0779 Zao Jiao Zhen皂角针 Chinese honeylocust spineGleditsia sinensis
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0043 Jie Zi芥子 India mustard seedBrassica juncea
H1061 Bai He百合 LilyLilium brownii
H0818 Zhi Zi栀子 Cape jasmine fruitGardenia jasminoides
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H0615 Wu Zhi Mao Tao五指毛桃 five-finger fig rootFicus simplicissima
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H0424 Shan Zhi山栀 Cape jasmineGardenia jasminoides
H0457 Shi Er石耳 Rock-EarsUmbilicaria esculenta
H0860 Zong Lv Zi棕榈子 NATrachycarpus fortunei
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0793 Zhao Shan Bai照山白 Manchurian rhododendronRhododendron micranthum
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0989 Ding Kui Cao丁葵草 Herb of twinleaf zorniaKummerowia striata
H1212 Hu Ye Gan Jin Gao槲叶干浸膏 NAQuercus dentata
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0784 Chi Shao赤芍 Red peony rootPaeonia obovata
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0857 Zong Ban Tan棕板炭 NATrachycarpus fortunei
H1068 Bai He Liu Jin Gao百合流浸膏 LilyLilium brownii
H0298 Niu Xi Xi牛西西 Patience dockRumex patientia
H0958 Dang Shen党参 Pilose asiabellCodonopsis pilosula
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0275 Mu Zei木贼 Common scouring rushEquisetum hiemale
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H1225 Huai Mi槐米 NASophora japonica
H1036 Fen Dan Pi粉丹皮 Tree peony barkPaeonia suffruticosa
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H0429 Shao Yao芍药 Red peony rootPaeonia obovata
H1029 Fang Er Cha方儿茶 khair in hindiSenegalia catechu
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0966 Di Ding地丁 All - grass of tokyo violetCorydalis bungeana
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H0925 Da Fu Zi大腹子 Areca palmAreca catechu
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H1133 Gui Jian Yu鬼箭羽 Winged euonymusEuonymus alatus
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H1227 Huai Zhi槐枝 NASophora japonica
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H0120 Ban Bian Qi半边旗 pinnated brake herbPteris semipinnata
H0856 Zong Ban棕板 NATrachycarpus fortunei
H0233 Mao Liang Mian Zhen毛两面针 NAZanthoxylum nitidum
H0660 Xiao Gan Cao小甘草 Root of ural licoriceRadix glycyrrhizae
H0021 Bai Shao白芍 Common peonyPaeonia lactiflora
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0069 Jin Ying Zi Ti Qu Ye金樱子提取液 Cherokee rose seedRosa laevigata
H0181 Luo Bu Ma罗布麻 DogbaneApocynum venetum
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0229 Mao Da Ding Cao毛大丁草 Pilose gerberaGerbera piloselloides
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H0105 Ku Di Ding苦地丁 Bunge corydalisCorydalis bungeana
H0574 Cao Dou Kou草豆蔻 Katsumada galangalAlpinia katsumadai
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H0939 Da Xue Teng大血藤 SargentgloryvineSargentodoxa cuneata
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H1201 Hu Er Cao虎耳草 Creeping rockfoilSaxifraga stolonifera
H1221 Hua Xiang Shu Guo Xu化香树果序 NAPlatycarya strobilacea
H1176 Hei Hu Jiao黑胡椒 Black pepperPiper nigrum
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0519 Suo Yang锁阳 Songaria cynomoriumCynomorium songaricum
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0067 Jin Ying Zi金樱子 Cherokee rose seedRosa laevigata
H0363 Rong Shu Ye榕树叶 BanyanFicus microcarpa
H0256 Ming Dang Shen明党参 Medicinal changiumChangium smyrnioides
H0365 Rou Dou Kou肉豆蔻 Common nutmegMyristica fragrans
H0152 Ling Zhi Jin Gao灵芝浸膏 NAGanoderma lucidum
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H1077 Bai Hu Jiao白胡椒 white pepperPiper nigrum
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0237 Mei Gui Hua玫瑰花 Rugose rose flowerRosa rugosa
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0020 Ji Yan Cao鸡眼草 Striate kummerowiaKummerowia striata
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0601 Wu Mei乌梅 Japanese apricotPrunus mume
H0534 Teng Li Gen藤梨根 NAActinidia arguta
H0248 Mi Ying Su Ke蜜罂粟壳 Opium poppyPapaver somniferum
H1214 Hua Jiao花椒 Bunge pricklyashZanthoxylum bungeanum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H1184 Bai Lian白蔹 Japanese ampelopsisAmpelopsis japonica
H0819 Zhi Zi Jin Gao栀子浸膏 Cape jasmine fruitGardenia jasminoides
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H1204 Hu Jiao胡椒 Black pepperPiper nigrum
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0343 Qing Hao Zi青蒿子 sweet wormwoodArtemisia carvifolia
H0757 Ying Su Ke罂粟壳 Opium poppy pericarpPapaver somniferum
H0959 Dang Shen Lu Tou党参芦头 Rhizome of pilose asiabellRhizoma codonopsis pilosulae
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0361 Ren Zi Cao人字草 Herb of twinleaf zorniaKummerowia striata
H1217 Bai Mei Hua白梅花 Japanese apricot flowerPrunus mume
H0858 Zong Lv Pi棕榈皮 Fortune windmillpalmTrachycarpus fortunei
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H0960 Dang Shen Qing Gao党参清膏 Root of hairy asiabellCodonopsis pilosula
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0118 Kun Ming Shan Hai Tang昆明山海棠 Glaucousback threewingnutTripterygium hypoglaucum
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1099 Gou Teng钩藤 Sharpleaf gambirplantUncaria rhynchophylla
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0777 Zao Jia皂荚 Chinese honeylocustGleditsia sinensis
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0006 Bai Qu Cai白屈菜 Greater celandineChelidonium majus
H0342 Qing Hao青蒿 sweet wormwoodArtemisia carvifolia
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0408 Bing Lang槟榔 BetenutpalmAreca catechu
H0068 Jin Ying Zi Rou金樱子肉 Cherokee rose seedRosa laevigata
H1004 Bai Cha白茶 White teaCamellia sinensis
H0023 Bai Shao Gan Jin Gao白芍干浸膏 Common peonyPaeonia lactiflora
H0764 Yu Xing Cao鱼腥草 Heartleaf houttuyniaHouttuynia cordata
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H1211 Bai Mei白眉 pilose gerbera herbGerbera piloselloides
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0351 Quan Shen拳参 BistortPolygonum bistorta
H0362 Rong Shu Xu榕树须 BanyanFicus microcarpa
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0153 Ling Zhi(1)灵芝 Lucid ganodermaGanoderma lucidum
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0602 Wu Mei Rou乌梅肉 EbonyPrunus mume
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0582 Cao Dou Kou Ren草豆蔻仁 Katsumada galangalAlpinia katsumadai
H1141 Guo Gang Long Jin Gao过岗龙浸膏 NAEntada phaseoloides
H1140 Guo Gang Long过岗龙 NAEntada phaseoloides
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H0007 Huo Xue Teng活血藤 NASargentodoxa cuneata
H0056 Jin Qiao Mai金荞麦 Wild buckwheat rhizomeRhizoma fagopyri cymosi
H1220 Hua Xiang Shu Guo化香树果 NAPlatycarya strobilacea
H0756 Ying Su罂粟 Opium poppyPapaver somniferum
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis