HIT-result

Target Description

Type	Detail
Target ID	T42O1D
Protein Name	Delta-type opioid receptor
Uniprot ID	P41143
Protein Name Alias	D-OR-1; DOR-1
Gene ID	4985
Gene Symbol	OPRD1
Gene Alias	OPRD
TTD	T58992: Successful target
Pfam	PF00001
GO	0010629:negative regulation of gene expression 0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 0033138:positive regulation of peptidyl-serine phosphorylation 0099061:integral component of postsynaptic density membrane 0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 0008344:adult locomotory behavior 0007186:G protein-coupled receptor signaling pathway 0032590:dendrite membrane 0071456:cellular response to hypoxia 0042277:peptide binding 0098992:neuronal dense core vesicle 0043679:axon terminus 0005886:plasma membrane 0042923:neuropeptide binding 0004930:G protein-coupled receptor activity 0043005:neuron projection 0051924:regulation of calcium ion transport 0005887:integral component of plasma membrane 0038003:opioid receptor signaling pathway 0038046:enkephalin receptor activity 0033612:receptor serine/threonine kinase binding 0097237:cellular response to toxic substance 0004985:opioid receptor activity 0007218:neuropeptide signaling pathway 0042755:eating behavior 0051930:regulation of sensory perception of pain 0031226:intrinsic component of plasma membrane 0071363:cellular response to growth factor stimulus 0019221:cytokine-mediated signaling pathway 0006955:immune response 0032793:positive regulation of CREB transcription factor activity 0045121:membrane raft 0031333:negative regulation of protein-containing complex assembly 0099056:integral component of presynaptic membrane 0007200:phospholipase C-activating G protein-coupled receptor signaling pathway 0030285:integral component of synaptic vesicle membrane 0097444:spine apparatus 0051881:regulation of mitochondrial membrane potential
PDB	4N6H ; 1OZC ; 4RWD ; 4RWA ; 6PT3 ; 6PT2 ; 2IQM
Drugbank	DB00497 ; DB01439 ; DB01192 ; DB00611 ; DB00854 ; DB01183 ; DB00318 ; DB00844 ; DB05050 ; DB09061 ; DB06738 ; DB11691 ; DB00327 ; DB11130 ; DB00708 ; DB00193 ; DB01535 ; DB09209 ; DB00704 ; DB00333 ; DB01444 ; DB06409 ; DB09272 ; DB14011 ; DB01548 ; DB00647 ; DB00956 ; DB00921 ; DB06274 ; DB00899 ; DB00321 ; DB06230 ; DB06204 ; DB01497 ; DB09173 ; DB01565 ; DB01452 ; DB14009 ; DB12668 ; DB01081 ; DB00836 ; DB01221 ; DB00295 ; DB01238 ; DB01571 ; DB00813 ; DB00514 ; DB14146
KEGG	hsa:4985

Type

Detail

Target ID

T42O1D

Protein Name

Delta-type opioid receptor

Uniprot ID

P41143

Protein Name Alias

D-OR-1; DOR-1

Gene ID

4985

Gene Symbol

OPRD1

Gene Alias

OPRD

TTD

T58992: Successful target

Pfam

PF00001

0010629:negative regulation of gene expression

0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

0033138:positive regulation of peptidyl-serine phosphorylation

0099061:integral component of postsynaptic density membrane

0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

0008344:adult locomotory behavior

0007186:G protein-coupled receptor signaling pathway

0032590:dendrite membrane

0071456:cellular response to hypoxia

0042277:peptide binding

0098992:neuronal dense core vesicle

0043679:axon terminus

0005886:plasma membrane

0042923:neuropeptide binding

0004930:G protein-coupled receptor activity

0043005:neuron projection

0051924:regulation of calcium ion transport

0005887:integral component of plasma membrane

0038003:opioid receptor signaling pathway

0038046:enkephalin receptor activity

0033612:receptor serine/threonine kinase binding

0097237:cellular response to toxic substance

0004985:opioid receptor activity

0007218:neuropeptide signaling pathway

0042755:eating behavior

0051930:regulation of sensory perception of pain

0031226:intrinsic component of plasma membrane

0071363:cellular response to growth factor stimulus

0019221:cytokine-mediated signaling pathway

0006955:immune response

0032793:positive regulation of CREB transcription factor activity

0045121:membrane raft

0031333:negative regulation of protein-containing complex assembly

0099056:integral component of presynaptic membrane

0007200:phospholipase C-activating G protein-coupled receptor signaling pathway

0030285:integral component of synaptic vesicle membrane

0097444:spine apparatus

0051881:regulation of mitochondrial membrane potential

PDB

4N6H ; 1OZC ; 4RWD ; 4RWA ; 6PT3 ; 6PT2 ; 2IQM

Drugbank

DB00497 ; DB01439 ; DB01192 ; DB00611 ; DB00854 ; DB01183 ; DB00318 ; DB00844 ; DB05050 ; DB09061 ; DB06738 ; DB11691 ; DB00327 ; DB11130 ; DB00708 ; DB00193 ; DB01535 ; DB09209 ; DB00704 ; DB00333 ; DB01444 ; DB06409 ; DB09272 ; DB14011 ; DB01548 ; DB00647 ; DB00956 ; DB00921 ; DB06274 ; DB00899 ; DB00321 ; DB06230 ; DB06204 ; DB01497 ; DB09173 ; DB01565 ; DB01452 ; DB14009 ; DB12668 ; DB01081 ; DB00836 ; DB01221 ; DB00295 ; DB01238 ; DB01571 ; DB00813 ; DB00514 ; DB14146

KEGG

hsa:4985

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0925	Da Fu Zi	大腹子	Areca palm	Areca catechu
H0757	Ying Su Ke	罂粟壳	Opium poppy pericarp	Papaver somniferum
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0958	Dang Shen	党参	Pilose asiabell	Codonopsis pilosula
H0960	Dang Shen Qing Gao	党参清膏	Root of hairy asiabell	Codonopsis pilosula
H0275	Mu Zei	木贼	Common scouring rush	Equisetum hiemale
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0248	Mi Ying Su Ke	蜜罂粟壳	Opium poppy	Papaver somniferum
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H0756	Ying Su	罂粟	Opium poppy	Papaver somniferum
H1226	Huai Shan Yao	淮山药	rhizome of biglcaf yam	Rhizoma dioscoreae
H0258	Mo Han Lian	墨旱莲	Yerbadetajo	Eclipta prostrata
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 16)