Target Description

Type Detail
Target ID T25C2G
Protein Name Nuclear receptor subfamily 4 group A member 1
Uniprot ID P22736
Protein Name Alias Early response protein NAK1;  Nuclear hormone receptor NUR/77;  Nur77;  Orphan nuclear receptor HMR;  Orphan nuclear receptor TR3;  ST-59;  Testicular receptor 3
Gene ID 3164
Gene Symbol NR4A1
Gene Alias GFRP1;  HMR;  NAK1
TTD T41119: Research target
Pfam PF00105 ; PF00104
GO
0005667:transcription regulator complex

0035259:glucocorticoid receptor binding

0035924:cellular response to vascular endothelial growth factor stimulus

1990837:sequence-specific double-stranded DNA binding

0001938:positive regulation of endothelial cell proliferation

0044344:cellular response to fibroblast growth factor stimulus

0002042:cell migration involved in sprouting angiogenesis

0005829:cytosol

0045444:fat cell differentiation

0004879:nuclear receptor activity

0046982:protein heterodimerization activity

0071376:cellular response to corticotropin-releasing hormone stimulus

0001228:DNA-binding transcription activator activity, RNA polymerase II-specific

0061469:regulation of type B pancreatic cell proliferation

0031965:nuclear membrane

0005654:nucleoplasm

0045786:negative regulation of cell cycle

0003677:DNA binding

0008270:zinc ion binding

0000785:chromatin

0005739:mitochondrion

0045944:positive regulation of transcription by RNA polymerase II

0005634:nucleus

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0006367:transcription initiation from RNA polymerase II promoter

0035767:endothelial cell chemotaxis

0007165:signal transduction

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0006357:regulation of transcription by RNA polymerase II

PDB 4RZG ; 4REE ; 4KZM ; 3V3Q ; 4WHG ; 4RZE ; 6LC1 ; 6KZ5 ; 4REF ; 4WHF ; 4KZJ ; 4JGV ; 4RE8 ; 4RZF ; 2QW4 ; 4KZI ; 3V3E
Drugbank NA
KEGG hsa:3164

Related Compounds  (Total: 5)

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C0330
Name: Prostaglandin A2
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C0415
Name: Stanolone
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C0639
Name: (+/-)Nicotine
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C0925
Name: Arundine
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C1222
Name: Celastrol


Related Herbs  (Total: 19)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0925 Da Fu Zi大腹子 Areca palmAreca catechu
H1077 Bai Hu Jiao白胡椒 white pepperPiper nigrum
H1204 Hu Jiao胡椒 Black pepperPiper nigrum
H0958 Dang Shen党参 Pilose asiabellCodonopsis pilosula
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0284 Nan She Teng南蛇藤 Oriental bittersweetCelastrus orbiculatus
H0130 Lei Gong Teng雷公藤 Common threewingnutTripterygium wilfordii
H1176 Hei Hu Jiao黑胡椒 Black pepperPiper nigrum
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H0180 Lu Zhu Gen芦竹根 Giantreed rhizomeArundo donax
H0275 Mu Zei木贼 Common scouring rushEquisetum hiemale
H0960 Dang Shen Qing Gao党参清膏 Root of hairy asiabellCodonopsis pilosula
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H0353 Que Mei Teng Gen雀梅藤根 Hedge sageretiaSageretia thea
H0408 Bing Lang槟榔 BetenutpalmAreca catechu