HIT-result

Target Description

Type	Detail
Target ID	T25C2G
Protein Name	Nuclear receptor subfamily 4 group A member 1
Uniprot ID	P22736
Protein Name Alias	Early response protein NAK1; Nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3
Gene ID	3164
Gene Symbol	NR4A1
Gene Alias	GFRP1; HMR; NAK1
TTD	T41119: Research target
Pfam	PF00105 ; PF00104
GO	0005667:transcription regulator complex 0035259:glucocorticoid receptor binding 0035924:cellular response to vascular endothelial growth factor stimulus 1990837:sequence-specific double-stranded DNA binding 0001938:positive regulation of endothelial cell proliferation 0044344:cellular response to fibroblast growth factor stimulus 0002042:cell migration involved in sprouting angiogenesis 0005829:cytosol 0045444:fat cell differentiation 0004879:nuclear receptor activity 0046982:protein heterodimerization activity 0071376:cellular response to corticotropin-releasing hormone stimulus 0001228:DNA-binding transcription activator activity, RNA polymerase II-specific 0061469:regulation of type B pancreatic cell proliferation 0031965:nuclear membrane 0005654:nucleoplasm 0045786:negative regulation of cell cycle 0003677:DNA binding 0008270:zinc ion binding 0000785:chromatin 0005739:mitochondrion 0045944:positive regulation of transcription by RNA polymerase II 0005634:nucleus 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0006367:transcription initiation from RNA polymerase II promoter 0035767:endothelial cell chemotaxis 0007165:signal transduction 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0006357:regulation of transcription by RNA polymerase II
PDB	4RZG ; 4REE ; 4KZM ; 3V3Q ; 4WHG ; 4RZE ; 6LC1 ; 6KZ5 ; 4REF ; 4WHF ; 4KZJ ; 4JGV ; 4RE8 ; 4RZF ; 2QW4 ; 4KZI ; 3V3E
Drugbank	NA
KEGG	hsa:3164

Type

Detail

Target ID

T25C2G

Protein Name

Nuclear receptor subfamily 4 group A member 1

Uniprot ID

P22736

Protein Name Alias

Early response protein NAK1; Nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3

Gene ID

3164

Gene Symbol

NR4A1

Gene Alias

GFRP1; HMR; NAK1

TTD

T41119: Research target

Pfam

PF00105 ; PF00104

0005667:transcription regulator complex

0035259:glucocorticoid receptor binding

0035924:cellular response to vascular endothelial growth factor stimulus

1990837:sequence-specific double-stranded DNA binding

0001938:positive regulation of endothelial cell proliferation

0044344:cellular response to fibroblast growth factor stimulus

0002042:cell migration involved in sprouting angiogenesis

0005829:cytosol

0045444:fat cell differentiation

0004879:nuclear receptor activity

0046982:protein heterodimerization activity

0071376:cellular response to corticotropin-releasing hormone stimulus

0001228:DNA-binding transcription activator activity, RNA polymerase II-specific

0061469:regulation of type B pancreatic cell proliferation

0031965:nuclear membrane

0005654:nucleoplasm

0045786:negative regulation of cell cycle

0003677:DNA binding

0008270:zinc ion binding

0000785:chromatin

0005739:mitochondrion

0045944:positive regulation of transcription by RNA polymerase II

0005634:nucleus

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0006367:transcription initiation from RNA polymerase II promoter

0035767:endothelial cell chemotaxis

0007165:signal transduction

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0006357:regulation of transcription by RNA polymerase II

PDB

4RZG ; 4REE ; 4KZM ; 3V3Q ; 4WHG ; 4RZE ; 6LC1 ; 6KZ5 ; 4REF ; 4WHF ; 4KZJ ; 4JGV ; 4RE8 ; 4RZF ; 2QW4 ; 4KZI ; 3V3E

Drugbank

KEGG

hsa:3164

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0925	Da Fu Zi	大腹子	Areca palm	Areca catechu
H0284	Nan She Teng	南蛇藤	Oriental bittersweet	Celastrus orbiculatus
H0180	Lu Zhu Gen	芦竹根	Giantreed rhizome	Arundo donax
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu
H0130	Lei Gong Teng	雷公藤	Common threewingnut	Tripterygium wilfordii
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0353	Que Mei Teng Gen	雀梅藤根	Hedge sageretia	Sageretia thea
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0314	Pu Gong Ying	蒲公英	Mongolian dandelion	Taraxacum mongolicum
H0315	Pu Gong Ying Jin Gao	蒲公英浸膏	Mongolian dandelion	Taraxacum mongolicum
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0958	Dang Shen	党参	Pilose asiabell	Codonopsis pilosula
H0960	Dang Shen Qing Gao	党参清膏	Root of hairy asiabell	Codonopsis pilosula
H0275	Mu Zei	木贼	Common scouring rush	Equisetum hiemale
H1244	Huang Miao	黄苗	NA	Taraxacum mongolicum
H0258	Mo Han Lian	墨旱莲	Yerbadetajo	Eclipta prostrata

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 19)