HIT-result

Type	Detail
Target ID	T32IXS
Protein Name	Integrin alpha-M
Uniprot ID	P11215
Protein Name Alias	CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD antigen CD11b
Gene ID	3684
Gene Symbol	ITGAM
Gene Alias	CD11B; CR3A
TTD	T95616: Clinical Trial target
Pfam	PF00092 ; PF00357 ; PF01839 ; PF08441
GO	0090314:positive regulation of protein targeting to membrane 0110090:positive regulation of hippocampal neuron apoptotic process 0005178:integrin binding 0034142:toll-like receptor 4 signaling pathway 0001540:amyloid-beta binding 0046872:metal ion binding 0098742:cell-cell adhesion via plasma-membrane adhesion molecules 0010668:ectodermal cell differentiation 0050900:leukocyte migration 0001774:microglial cell activation 0038024:cargo receptor activity 0005886:plasma membrane 0001851:complement component C3b binding 0150062:complement-mediated synapse pruning 0070062:extracellular exosome 0034688:integrin alphaM-beta2 complex 1901216:positive regulation of neuron death 0150064:vertebrate eye-specific patterning 0043315:positive regulation of neutrophil degranulation 0032930:positive regulation of superoxide anion generation 0045087:innate immune response 0007155:cell adhesion 0045963:negative regulation of dopamine metabolic process 0044853:plasma membrane raft 0007229:integrin-mediated signaling pathway 0097190:apoptotic signaling pathway 0006911:phagocytosis, engulfment 0043312:neutrophil degranulation 0009986:cell surface 0097242:amyloid-beta clearance 0070821:tertiary granule membrane 0009897:external side of plasma membrane 1905114:cell surface receptor signaling pathway involved in cell-cell signaling 0030198:extracellular matrix organization 2000363:positive regulation of prostaglandin-E synthase activity 0006898:receptor-mediated endocytosis 0005615:extracellular space 0019221:cytokine-mediated signaling pathway 0031072:heat shock protein binding 0030900:forebrain development 0035579:specific granule membrane 1904151:positive regulation of microglial cell mediated cytotoxicity 0008305:integrin complex
PDB	2LKJ ; 1IDO ; 1JLM ; 2LKE ; 4XW2 ; 1BHO ; 1NA5 ; 1N9Z ; 1MF7 ; 3QA3 ; 6RHW ; 3Q3G ; 4M76 ; 1IDN ; 1M1U ; 1BHQ ; 1A8X
Drugbank	NA
KEGG	hsa:3684

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0004	Huo Xiang	藿香	Patchouli	Pogostemon cablin
H0437	She Xiang	麝香	Abelmusk	Moschus moschiferus
H0416	Shan Shen	山参	NA	Panax ginseng
H0235	Mao She Xiang	毛麝香	Abelmusk	Moschus moschiferus
H0329	Qian Niu Zi	牵牛子	Lobedleaf pharbitis seed	Pharbitis nil
H0236	Mao She Xiang Jin Gao	毛麝香浸膏	Abelmusk	Moschus moschiferus
H0590	Wei Ling	威灵	Chinese clematis	Clematis chinensis
H0520	Tai Pan Fen	胎盘粉	Fetus powder	Human placenta
H0832	Zhu Sha Gen	朱砂根	Coral ardisia	Ardisia crenata
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0385	San Qi Ye Jing	三七叶茎	Sanchi	Panax notoginseng
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H1011	Bai Chou	白丑	Pharbitis seed	Semen pharbitidis
H0258	Mo Han Lian	墨旱莲	Yerbadetajo	Eclipta prostrata
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H0356	Ren Gong She Xiang	人工麝香	Abelmusk	Moschus moschiferus
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0925	Da Fu Zi	大腹子	Areca palm	Areca catechu
H0382	San Qi Hua	三七花	Sanchi	Panax notoginseng
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H0958	Dang Shen	党参	Pilose asiabell	Codonopsis pilosula
H0848	Zi Jin Niu	紫金牛	Japanese ardisia	Ardisia japonica
H1102	Gu Sui Bu	骨碎补	Fortune’s drynaria rhizome	Drynaria fortunei
H0077	Jiu	酒	Ethanol	Vinum
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0522	Tai Zi Shen	太子参	Heterophylly falsestarwort root	Radix pseudostellariae
H0005	Huo Xiang Ye	藿香叶	Patchouli	Pogostemon cablin
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0521	Tai Pan Zu Zhi Fen	胎盘组织粉	NA	Human placenta
H0572	Tu Huo Xiang	土藿香	Patchouli	Pogostemon cablin
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H1120	Guang Huo Xiang	广藿香	Patchouli	Pogostemon cablin
H1173	Hei Chou	黑丑	Pharbitis seed	Semen pharbitidis
H0661	Xiao Hei Dou	小黑豆	Black turtle bean	Phaseolus vulgaris
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu
H0383	San Qi Jing Ye	三七茎叶	Sanchi	Panax notoginseng
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis
H0384	San Qi Ye	三七叶	Folium panax notoginseng	Panax notoginseng
H0275	Mu Zei	木贼	Common scouring rush	Equisetum hiemale
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0380	San Qi Gan Jin Gao	三七干浸膏	Sanchi	Panax notoginseng
H0592	Wei Ling Xian	威灵仙	Chinese clematis	Clematis chinensis
H1010	Du Huo Xiang	杜藿香	Patchouli	Pogostemon cablin
H0960	Dang Shen Qing Gao	党参清膏	Root of hairy asiabell	Codonopsis pilosula
H0381	San Qi Gao Fen	三七膏粉	Sanchi	Panax notoginseng
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum

Target Description

Related Compounds (Total: 11)

Related Herbs (Total: 55)