Compound Description

ID:   C0865 Common name:   Aicar
IUPAC:  [(2R,3S,4R,5R)-5-(5-amino-4-carbamoylimidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate CAS:  CAS:3031-94-5
Chembl ID:   CHEMBL483849 Pubchem ID:   CID:65110
Formula:  C9H15N4O8P TCM-ID:  TCMC643
Smiles:  O[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc(c1N)C(=N)O)COP(=O)(O)O
Alias:

Imidazole-4-carboxamide, 5-amino-1-β-D-ribofuranosyl-, 5'-(dihydrogen phosphate);

Imidazole-4-carboxamide, 5-amino-1-β-D-ribofuranosyl-, 5'-phosphate;

5-Amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazole-4-carboxamide;

(2R,3 S,4R,5R)-5-(4-Carbam0yl-5-aminoimidazol-1-yl)-3,4-dihydroxyoxolan-2-yljmethyl dihydrogen phosphate;

5-Amino-1-(5'-phosphofuranoribosyl)-4-imidazolecarboxamide;

5-Amino-1β-D-ribofuranosylimidazole-4-carboxamide 5'-phosphate;

5-Amino-4-imidazolecarboxamide ribonucleoside 5'-monophosphate;

5-Amino-4-imidazolecarboxamide ribonucleotide;

5-Amino-4-imidazolecarboxamide riboside 5'-monophosphate;

5-Amino-4-imidazolecarboxamide ribotide;

5-Aminoimidazole-4-carboxamide ribonucleotide;

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate;

5'-Phospho-β-D-ribosyl-5-amino-4-imidazolecarboxamide;

5'-Phosphoribosyl-5-amino-4-imidazolecarboxamide;

AICA Ribotide;

AICA-Ribonucleotide;

AICAR;

AICAR (5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5'-monophosphate);

Acadesine 5'-monophosphate;

Aminoimidazolecarboxamide ribonucleotide;

NSC 283955;

NSC 292227;

ZMP;

ZMP (alarmone)
Structure:

Related Targets  (Total: 26)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T81I4T 5'-AMP-activated protein kinase catalytic subunit alpha-1PRKAA1 Q13131
A 29 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
A 1 Reference(s)
T43SM9 Peroxisome proliferator-activated receptor gamma coactivator 1-alphaPPARGC1A Q9UBK2
A 2 Reference(s)
T71PTC Protein kinase C iota typePRKCI P41743
A 1 Reference(s)
T85H5E N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylaseOGG1 O15527
A 1 Reference(s)
T67LL5 Regulatory-associated protein of mTORRPTOR Q8N122
B 1 Reference(s)
T74QXI Serine/threonine-protein kinase mTORMTOR P42345
C 1 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
C 1 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
C 1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
C 1 Reference(s)
T38ILG Zinc finger protein PLAGL1PLAGL1 Q9UM63
C 1 Reference(s)
T11FH6 Phosphatidylinositol 3-kinase regulatory subunit alphaPIK3R1 P27986
C 1 Reference(s)
T37VPC Homeobox protein NANOGNANOG Q9H9S0
C 1 Reference(s)
T79RG1 Myosin-2MYH2 Q9UKX2
C 1 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
C 1 Reference(s)
T26EZU Myc proto-oncogene proteinMYC P01106
C 1 Reference(s)
T51WGR Pancreas/duodenum homeobox protein 1PDX1 P52945
C 1 Reference(s)
T39FBA Thioredoxin-interacting proteinTXNIP Q9H3M7
C 1 Reference(s)
T32IXS Integrin alpha-MITGAM P11215
C 1 Reference(s)
T16A8U ELAV-like protein 1ELAVL1 Q15717
C 1 Reference(s)
T93WZG G1/S-specific cyclin-D1CCND1 P24385
C 1 Reference(s)
T49ORJ Peroxisome proliferator-activated receptor alphaPPARA Q07869
C 1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
C 1 Reference(s)
T17AMT NAMIR34A NA
C 1 Reference(s)
T18USV NAMIR34B NA
C 1 Reference(s)
T87GZ4 NAMIR34C NA
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 2)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens