HIT-result

Target Description

Type	Detail
Target ID	T43SM9
Protein Name	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Uniprot ID	Q9UBK2
Protein Name Alias	PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ligand effect modulator 6
Gene ID	10891
Gene Symbol	PPARGC1A
Gene Alias	LEM6; PGC1; PGC1A; PPARGC1
TTD	NA
Pfam	PF00076
GO	0022904:respiratory electron transport chain 1901558:response to metformin 0045333:cellular respiration 1901860:positive regulation of mitochondrial DNA metabolic process 0014850:response to muscle activity 0008134:transcription factor binding 0045820:negative regulation of glycolytic process 1990844:interfibrillar mitochondrion 0003713:transcription coactivator activity 0042975:peroxisome proliferator activated receptor binding 0042594:response to starvation 0035066:positive regulation of histone acetylation 0000422:autophagy of mitochondrion 0071456:cellular response to hypoxia 0097009:energy homeostasis 0003712:transcription coregulator activity 0071333:cellular response to glucose stimulus 0065003:protein-containing complex assembly 1990841:promoter-specific chromatin binding 0042752:regulation of circadian rhythm 0034599:cellular response to oxidative stress 0006367:transcription initiation from RNA polymerase II promoter 0006012:galactose metabolic process 0019395:fatty acid oxidation 0007623:circadian rhythm 0001933:negative regulation of protein phosphorylation 1901857:positive regulation of cellular respiration 0097067:cellular response to thyroid hormone stimulus 0006355:regulation of transcription, DNA-templated 0051091:positive regulation of DNA-binding transcription factor activity 0071354:cellular response to interleukin-6 0097440:apical dendrite 0010822:positive regulation of mitochondrion organization 0043025:neuronal cell body 0001659:temperature homeostasis 2001171:positive regulation of ATP biosynthetic process 0071372:cellular response to follicle-stimulating hormone stimulus 0071332:cellular response to fructose stimulus 0045722:positive regulation of gluconeogenesis 0030900:forebrain development 0050821:protein stabilization 2000272:negative regulation of signaling receptor activity 0014732:skeletal muscle atrophy 0043014:alpha-tubulin binding 0002931:response to ischemia 0003723:RNA binding 0009409:response to cold 0000302:response to reactive oxygen species 0071222:cellular response to lipopolysaccharide 1904640:response to methionine 0071250:cellular response to nitrite 0043524:negative regulation of neuron apoptotic process 0016922:nuclear receptor binding 0008380:RNA splicing 1904637:cellular response to ionomycin 0071560:cellular response to transforming growth factor beta stimulus 0000785:chromatin 0021549:cerebellum development 1904639:cellular response to resveratrol 0060612:adipose tissue development 0007586:digestion 0042493:response to drug 0031625:ubiquitin protein ligase binding 0002021:response to dietary excess 0008209:androgen metabolic process 0007005:mitochondrion organization 0071871:response to epinephrine 0005654:nucleoplasm 0043565:sequence-specific DNA binding 1901215:negative regulation of neuron death 0048661:positive regulation of smooth muscle cell proliferation 0003677:DNA binding 0050873:brown fat cell differentiation 0071392:cellular response to estradiol stimulus 0051552:flavone metabolic process 0045944:positive regulation of transcription by RNA polymerase II 0030331:estrogen receptor binding 0016605:PML body 1904635:positive regulation of glomerular visceral epithelial cell apoptotic process 0005634:nucleus 1990843:subsarcolemmal mitochondrion 0010628:positive regulation of gene expression 0071356:cellular response to tumor necrosis factor 0032922:circadian regulation of gene expression 0071313:cellular response to caffeine 0048662:negative regulation of smooth muscle cell proliferation 0030374:nuclear receptor coactivator activity 0007568:aging 0046321:positive regulation of fatty acid oxidation 0120162:positive regulation of cold-induced thermogenesis 0014912:negative regulation of smooth muscle cell migration 2000310:regulation of NMDA receptor activity 0043201:response to leucine 0006397:mRNA processing 0031490:chromatin DNA binding 1990845:adaptive thermogenesis 0045893:positive regulation of transcription, DNA-templated 0090258:negative regulation of mitochondrial fission 1901863:positive regulation of muscle tissue development 0001678:cellular glucose homeostasis 0022626:cytosolic ribosome 0071873:response to norepinephrine 2000184:positive regulation of progesterone biosynthetic process 0043231:intracellular membrane-bounded organelle 0035865:cellular response to potassium ion 0006094:gluconeogenesis 0014878:response to electrical stimulus involved in regulation of muscle adaptation
PDB	6NWL ; 3B1M ; 6AD9 ; 6KXX ; 3V9T ; 6LN4 ; 6W9K ; 6NWK ; 5Q0I ; 6KXY ; 5Z6S ; 1XB7 ; 6MS7 ; 3CS8 ; 3U9Q ; 5TWO ; 6FZP ; 6IZN ; 5UNJ ; 6K0T ; 4QK4 ; 5Z5S ; 4QJR ; 3D24 ; 6IZM ; 3V9V ; 6FZF ; 6W9L
Drugbank	NA
KEGG	hsa:10891

Type

Detail

Target ID

T43SM9

Protein Name

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Uniprot ID

Q9UBK2

Protein Name Alias

PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ligand effect modulator 6

Gene ID

10891

Gene Symbol

PPARGC1A

Gene Alias

LEM6; PGC1; PGC1A; PPARGC1

TTD

Pfam

PF00076

0022904:respiratory electron transport chain

1901558:response to metformin

0045333:cellular respiration

1901860:positive regulation of mitochondrial DNA metabolic process

0014850:response to muscle activity

0008134:transcription factor binding

0045820:negative regulation of glycolytic process

1990844:interfibrillar mitochondrion

0003713:transcription coactivator activity

0042975:peroxisome proliferator activated receptor binding

0042594:response to starvation

0035066:positive regulation of histone acetylation

0000422:autophagy of mitochondrion

0071456:cellular response to hypoxia

0097009:energy homeostasis

0003712:transcription coregulator activity

0071333:cellular response to glucose stimulus

0065003:protein-containing complex assembly

1990841:promoter-specific chromatin binding

0042752:regulation of circadian rhythm

0034599:cellular response to oxidative stress

0006367:transcription initiation from RNA polymerase II promoter

0006012:galactose metabolic process

0019395:fatty acid oxidation

0007623:circadian rhythm

0001933:negative regulation of protein phosphorylation

1901857:positive regulation of cellular respiration

0097067:cellular response to thyroid hormone stimulus

0006355:regulation of transcription, DNA-templated

0051091:positive regulation of DNA-binding transcription factor activity

0071354:cellular response to interleukin-6

0097440:apical dendrite

0010822:positive regulation of mitochondrion organization

0043025:neuronal cell body

0001659:temperature homeostasis

2001171:positive regulation of ATP biosynthetic process

0071372:cellular response to follicle-stimulating hormone stimulus

0071332:cellular response to fructose stimulus

0045722:positive regulation of gluconeogenesis

0030900:forebrain development

0050821:protein stabilization

2000272:negative regulation of signaling receptor activity

0014732:skeletal muscle atrophy

0043014:alpha-tubulin binding

0002931:response to ischemia

0003723:RNA binding

0009409:response to cold

0000302:response to reactive oxygen species

0071222:cellular response to lipopolysaccharide

1904640:response to methionine

0071250:cellular response to nitrite

0043524:negative regulation of neuron apoptotic process

0016922:nuclear receptor binding

0008380:RNA splicing

1904637:cellular response to ionomycin

0071560:cellular response to transforming growth factor beta stimulus

0000785:chromatin

0021549:cerebellum development

1904639:cellular response to resveratrol

0060612:adipose tissue development

0007586:digestion

0042493:response to drug

0031625:ubiquitin protein ligase binding

0002021:response to dietary excess

0008209:androgen metabolic process

0007005:mitochondrion organization

0071871:response to epinephrine

0005654:nucleoplasm

0043565:sequence-specific DNA binding

1901215:negative regulation of neuron death

0048661:positive regulation of smooth muscle cell proliferation

0003677:DNA binding

0050873:brown fat cell differentiation

0071392:cellular response to estradiol stimulus

0051552:flavone metabolic process

0045944:positive regulation of transcription by RNA polymerase II

0030331:estrogen receptor binding

0016605:PML body

1904635:positive regulation of glomerular visceral epithelial cell apoptotic process

0005634:nucleus

1990843:subsarcolemmal mitochondrion

0010628:positive regulation of gene expression

0071356:cellular response to tumor necrosis factor

0032922:circadian regulation of gene expression

0071313:cellular response to caffeine

0048662:negative regulation of smooth muscle cell proliferation

0030374:nuclear receptor coactivator activity

0007568:aging

0046321:positive regulation of fatty acid oxidation

0120162:positive regulation of cold-induced thermogenesis

0014912:negative regulation of smooth muscle cell migration

2000310:regulation of NMDA receptor activity

0043201:response to leucine

0006397:mRNA processing

0031490:chromatin DNA binding

1990845:adaptive thermogenesis

0045893:positive regulation of transcription, DNA-templated

0090258:negative regulation of mitochondrial fission

1901863:positive regulation of muscle tissue development

0001678:cellular glucose homeostasis

0022626:cytosolic ribosome

0071873:response to norepinephrine

2000184:positive regulation of progesterone biosynthetic process

0043231:intracellular membrane-bounded organelle

0035865:cellular response to potassium ion

0006094:gluconeogenesis

0014878:response to electrical stimulus involved in regulation of muscle adaptation

PDB

6NWL ; 3B1M ; 6AD9 ; 6KXX ; 3V9T ; 6LN4 ; 6W9K ; 6NWK ; 5Q0I ; 6KXY ; 5Z6S ; 1XB7 ; 6MS7 ; 3CS8 ; 3U9Q ; 5TWO ; 6FZP ; 6IZN ; 5UNJ ; 6K0T ; 4QK4 ; 5Z5S ; 4QJR ; 3D24 ; 6IZM ; 3V9V ; 6FZF ; 6W9L

Drugbank

KEGG

hsa:10891

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0094	Gou Qi	枸杞	Chinese wolfberry fruit	Lycium chinense
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H1062	Fu Zi	附子	Prepared common monkshood daughter root	Aconitum carmichaeli
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0095	Gou Qi Zi	枸杞子	Chinese wolfberry fruit	Lycium chinense
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0618	Cao Wu	草乌	Kusnezoff monkshood root	Aconitum carmichaelii
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0416	Shan Shen	山参	NA	Panax ginseng
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0884	Chuan Wu	川乌	root of common monkshood	Radix aconiti

Target Description

Related Compounds (Total: 9)

Related Herbs (Total: 33)