| ID: C0403 | Common name: Silibinin | 
| IUPAC: 3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one | CAS: CAS:22888-70-6 | 
| Chembl ID: CHEMBL1401508 | Pubchem ID: CID:5213 | 
| Formula: C25H22O10 | TCM-ID: TCMC2079 | 
| Smiles: OCC1Oc2ccc(cc2OC1c1ccc(c(c1)OC)O)C1Oc2cc(O)cc(c2C(=O)C1O)O | |
| Alias: 
                        
                        4-Chromanone, 3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxan-6-yl]-; 4H-1-Benzopyran-4-one, 2-[2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, [2R-[2α,3β,6(2R*,3R*)]]-; Silybin; (2R,3R)-2-[(2R,3R)-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one; 1,4-Benzodioxin, 4H-1-benzopyran-4-one deriv.; 7C3MT; Mepasil; Realsil; Silibinin; Silibinin A; Silliver; Silybin A; Silybin b1; Silybine; Silybum substance E6; Silymarin I; Silymarin MZ 80; Silymarine I | Structure:   | 
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence | 
|---|---|---|---|---|---|
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 | P40763 | A | 2 Reference(s) | 
| T05O6O | Estrogen receptor beta | ESR2 | Q92731 | A | 2 Reference(s) | 
| T64X48 | C-X-C chemokine receptor type 4 | CXCR4 | P61073 | A | 2 Reference(s) | 
| T47H3O | Heat shock protein HSP 90-alpha | HSP90AA1 | P07900 | A | 1 Reference(s) | 
| T09H2Z | Nitric oxide synthase, inducible | NOS2 | P35228 | A | 2 Reference(s) | 
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 | P31749 | A | 1 Reference(s) | 
| T27LA6 | DNA | DNMT1 | P26358 | A | 1 Reference(s) | 
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA | Q07869 | C | 1 Reference(s) | 
| T43SM9 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | PPARGC1A | Q9UBK2 | C | 1 Reference(s) | 
| T02Z3O | Low-density lipoprotein receptor-related protein 6 | LRP6 | O75581 | C | 1 Reference(s) | 
| T10H9X | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | OGT | O15294 | C | 1 Reference(s) | 
| T82JWE | Cellular tumor antigen p53 | TP53 | P04637 | C | 1 Reference(s) | 
| T43N2D | Epidermal growth factor receptor | EGFR | P00533 | C | 1 Reference(s) | 
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 | P35354 | C | 1 Reference(s) | 
| T87F4H | Insulin-induced gene 1 protein | INSIG1 | O15503 | C | 1 Reference(s) | 
| T40JZG | GPI-anchor transamidase | PIGK | Q92643 | C | 1 Reference(s) | 
| T93SFQ | NAD-dependent protein deacetylase sirtuin-1 | SIRT1 | Q96EB6 | C | 1 Reference(s) | 
| T33OSQ | Sterol regulatory element-binding protein 1 | SREBF1 | P36956 | C | 1 Reference(s) | 
| T68M1D | Histone deacetylase 2 | HDAC2 | Q92769 | C | 1 Reference(s) | 
| T57HGP | Tumor necrosis factor receptor superfamily member 6 | FAS | P25445 | C | 1 Reference(s) |