HIT-result

Type	Detail
Target ID	T02Z3O
Protein Name	Low-density lipoprotein receptor-related protein 6
Uniprot ID	O75581
Protein Name Alias	LRP-6
Gene ID	4040
Gene Symbol	LRP6
Gene Alias	NA
TTD	T49755: Clinical Trial target
Pfam	PF00057 ; PF00058
GO	0042802:identical protein binding 0060325:face morphogenesis 0005109:frizzled binding 0017147:Wnt-protein binding 1990851:Wnt-Frizzled-LRP5/6 complex 0006469:negative regulation of protein kinase activity 0015026:coreceptor activity 0060059:embryonic retina morphogenesis in camera-type eye 0043434:response to peptide hormone 0030901:midbrain development 0007268:chemical synaptic transmission 0048596:embryonic camera-type eye morphogenesis 0030326:embryonic limb morphogenesis 0007204:positive regulation of cytosolic calcium ion concentration 0060349:bone morphogenesis 0019210:kinase inhibitor activity 0090245:axis elongation involved in somitogenesis 0046849:bone remodeling 0090118:receptor-mediated endocytosis involved in cholesterol transport 0090244:Wnt signaling pathway involved in somitogenesis 0019534:toxin transmembrane transporter activity 0044335:canonical Wnt signaling pathway involved in neural crest cell differentiation 0014029:neural crest formation 1904886:beta-catenin destruction complex disassembly 0060444:branching involved in mammary gland duct morphogenesis 0014033:neural crest cell differentiation 0071542:dopaminergic neuron differentiation 0021987:cerebral cortex development 0031410:cytoplasmic vesicle 0042813:Wnt-activated receptor activity 0045787:positive regulation of cell cycle 0060021:roof of mouth development 0001843:neural tube closure 0071936:coreceptor activity involved in Wnt signaling pathway 0021794:thalamus development 0005041:low-density lipoprotein particle receptor activity 0071901:negative regulation of protein serine/threonine kinase activity 0060070:canonical Wnt signaling pathway 0005783:endoplasmic reticulum 0005886:plasma membrane 0030917:midbrain-hindbrain boundary development 0016055:Wnt signaling pathway 0035261:external genitalia morphogenesis 0009880:embryonic pattern specification 0045121:membrane raft 0016021:integral component of membrane 1990909:Wnt signalosome 0060026:convergent extension 0001933:negative regulation of protein phosphorylation 1904928:coreceptor activity involved in canonical Wnt signaling pathway 0060535:trachea cartilage morphogenesis 0045202:synapse 0042475:odontogenesis of dentin-containing tooth 1904953:Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 0071397:cellular response to cholesterol 0009986:cell surface 0034392:negative regulation of smooth muscle cell apoptotic process 0044340:canonical Wnt signaling pathway involved in regulation of cell proliferation 0031901:early endosome membrane 0090009:primitive streak formation 0072659:protein localization to plasma membrane 0021587:cerebellum morphogenesis 0003344:pericardium morphogenesis 0005576:extracellular region 0051091:positive regulation of DNA-binding transcription factor activity 0045893:positive regulation of transcription, DNA-templated 0005102:signaling receptor binding 0042803:protein homodimerization activity 0098609:cell-cell adhesion 0090090:negative regulation of canonical Wnt signaling pathway 1904948:midbrain dopaminergic neuron differentiation 0043025:neuronal cell body 0030278:regulation of ossification 0045944:positive regulation of transcription by RNA polymerase II 0034185:apolipoprotein binding
PDB	3S8Z ; 4DG6 ; 5GJE ; 3S8V ; 3S94 ; 6H15 ; 3SOV ; 5AIR ; 4NM7 ; 3SOQ ; 4A0P ; 3S2K ; 6H16 ; 6L6R ; 4NM5 ; 3SOB ; 5FWW
Drugbank	NA
KEGG	hsa:4040

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Name: Silibinin

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Name: Cholesterol

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0095	Gou Qi Zi	枸杞子	Chinese wolfberry fruit	Lycium chinense
H0838	Zhu Zi Shen	珠子参	Largeleaf japanese ginseng rhizome	Rhizoma panacis majoris
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0094	Gou Qi	枸杞	Chinese wolfberry fruit	Lycium chinense