Target Description

Type Detail
Target ID T68M1D
Protein Name Histone deacetylase 2
Uniprot ID Q92769
Protein Name Alias HD2;  EC 3.5.1.98
Gene ID 3066
Gene Symbol HDAC2
Gene Alias NA
TTD T51191: Clinical Trial target
Pfam PF00850
GO
0008134:transcription factor binding

0005634:nucleus

0061029:eyelid development in camera-type eye

0003300:cardiac muscle hypertrophy

0004407:histone deacetylase activity

0043044:ATP-dependent chromatin remodeling

0070301:cellular response to hydrogen peroxide

0061000:negative regulation of dendritic spine development

0043565:sequence-specific DNA binding

0061198:fungiform papilla formation

0033558:protein deacetylase activity

0000118:histone deacetylase complex

0032732:positive regulation of interleukin-1 production

0016581:NuRD complex

1903351:cellular response to dopamine

0003682:chromatin binding

0001103:RNA polymerase II repressing transcription factor binding

0009913:epidermal cell differentiation

0048714:positive regulation of oligodendrocyte differentiation

0035098:ESC/E(Z) complex

0008284:positive regulation of cell population proliferation

0001975:response to amphetamine

0045347:negative regulation of MHC class II biosynthetic process

0071560:cellular response to transforming growth factor beta stimulus

0042733:embryonic digit morphogenesis

0032041:NAD-dependent histone deacetylase activity (H3-K14 specific)

0045892:negative regulation of transcription, DNA-templated

0005737:cytoplasm

1901796:regulation of signal transduction by p53 class mediator

0051059:NF-kappaB binding

0007596:blood coagulation

0019899:enzyme binding

0032922:circadian regulation of gene expression

0070933:histone H4 deacetylation

0000785:chromatin

1990841:promoter-specific chromatin binding

0043392:negative regulation of DNA binding

0042493:response to drug

0042531:positive regulation of tyrosine phosphorylation of STAT protein

0019213:deacetylase activity

0003723:RNA binding

0070932:histone H3 deacetylation

0042475:odontogenesis of dentin-containing tooth

0032967:positive regulation of collagen biosynthetic process

0035094:response to nicotine

0032991:protein-containing complex

0031000:response to caffeine

0031072:heat shock protein binding

0016575:histone deacetylation

0045862:positive regulation of proteolysis

0010718:positive regulation of epithelial to mesenchymal transition

0045893:positive regulation of transcription, DNA-templated

0071300:cellular response to retinoic acid

0070829:heterochromatin maintenance

0043433:negative regulation of DNA-binding transcription factor activity

0048149:behavioral response to ethanol

0000122:negative regulation of transcription by RNA polymerase II

2000273:positive regulation of signaling receptor activity

0032760:positive regulation of tumor necrosis factor production

0060789:hair follicle placode formation

0010977:negative regulation of neuron projection development

0016358:dendrite development

0032496:response to lipopolysaccharide

0005654:nucleoplasm

0006338:chromatin remodeling

0034605:cellular response to heat

2000757:negative regulation of peptidyl-lysine acetylation

0016580:Sin3 complex

0045944:positive regulation of transcription by RNA polymerase II

0055093:response to hyperoxia

0042826:histone deacetylase binding

1902437:positive regulation of male mating behavior

0043066:negative regulation of apoptotic process

0042220:response to cocaine

PDB 5IX0 ; 6WBZ ; 5IWG ; 7KBG ; 7KBH ; 6G3O ; 6WBW ; 4LXZ ; 3MAX ; 6XEB ; 6XEC ; 6XDM ; 4LY1
Drugbank DB01303 ; DB05015 ; DB00175 ; DB06176 ; DB00227 ; DB05223 ; DB01223 ; DB00641 ; DB00277 ; DB02546 ; DB01076 ; DB11830 ; DB06603 ; DB00313 ; DB09091 ; DB01095
KEGG hsa:3066

Related Compounds  (Total: 5)

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C0012
Name: Diazepam
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C0403
Name: Silibinin
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C0477
Name: Valproic Acid
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C0803
Name: Apicidin
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C0867
Name: Alcohol


Related Herbs  (Total: 16)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0794 Zhe Bei Mu浙贝母 Thunberg fritillaryFritillaria verticillata var. thunbergii
H0357 Ren Shen人参 GinsengPanax ginseng
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0095 Gou Qi Zi枸杞子 Chinese wolfberry fruitLycium chinense
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0094 Gou Qi枸杞 Chinese wolfberry fruitLycium chinense
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0938 Da Suan大蒜 GarlicAllium sativum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0522 Tai Zi Shen太子参 Heterophylly falsestarwort rootRadix pseudostellariae
H0416 Shan Shen山参 NAPanax ginseng
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera