HIT-result

Target Description

Type	Detail
Target ID	T68M1D
Protein Name	Histone deacetylase 2
Uniprot ID	Q92769
Protein Name Alias	HD2; EC 3.5.1.98
Gene ID	3066
Gene Symbol	HDAC2
Gene Alias	NA
TTD	T51191: Clinical Trial target
Pfam	PF00850
GO	0008134:transcription factor binding 0005634:nucleus 0061029:eyelid development in camera-type eye 0003300:cardiac muscle hypertrophy 0004407:histone deacetylase activity 0043044:ATP-dependent chromatin remodeling 0070301:cellular response to hydrogen peroxide 0061000:negative regulation of dendritic spine development 0043565:sequence-specific DNA binding 0061198:fungiform papilla formation 0033558:protein deacetylase activity 0000118:histone deacetylase complex 0032732:positive regulation of interleukin-1 production 0016581:NuRD complex 1903351:cellular response to dopamine 0003682:chromatin binding 0001103:RNA polymerase II repressing transcription factor binding 0009913:epidermal cell differentiation 0048714:positive regulation of oligodendrocyte differentiation 0035098:ESC/E(Z) complex 0008284:positive regulation of cell population proliferation 0001975:response to amphetamine 0045347:negative regulation of MHC class II biosynthetic process 0071560:cellular response to transforming growth factor beta stimulus 0042733:embryonic digit morphogenesis 0032041:NAD-dependent histone deacetylase activity (H3-K14 specific) 0045892:negative regulation of transcription, DNA-templated 0005737:cytoplasm 1901796:regulation of signal transduction by p53 class mediator 0051059:NF-kappaB binding 0007596:blood coagulation 0019899:enzyme binding 0032922:circadian regulation of gene expression 0070933:histone H4 deacetylation 0000785:chromatin 1990841:promoter-specific chromatin binding 0043392:negative regulation of DNA binding 0042493:response to drug 0042531:positive regulation of tyrosine phosphorylation of STAT protein 0019213:deacetylase activity 0003723:RNA binding 0070932:histone H3 deacetylation 0042475:odontogenesis of dentin-containing tooth 0032967:positive regulation of collagen biosynthetic process 0035094:response to nicotine 0032991:protein-containing complex 0031000:response to caffeine 0031072:heat shock protein binding 0016575:histone deacetylation 0045862:positive regulation of proteolysis 0010718:positive regulation of epithelial to mesenchymal transition 0045893:positive regulation of transcription, DNA-templated 0071300:cellular response to retinoic acid 0070829:heterochromatin maintenance 0043433:negative regulation of DNA-binding transcription factor activity 0048149:behavioral response to ethanol 0000122:negative regulation of transcription by RNA polymerase II 2000273:positive regulation of signaling receptor activity 0032760:positive regulation of tumor necrosis factor production 0060789:hair follicle placode formation 0010977:negative regulation of neuron projection development 0016358:dendrite development 0032496:response to lipopolysaccharide 0005654:nucleoplasm 0006338:chromatin remodeling 0034605:cellular response to heat 2000757:negative regulation of peptidyl-lysine acetylation 0016580:Sin3 complex 0045944:positive regulation of transcription by RNA polymerase II 0055093:response to hyperoxia 0042826:histone deacetylase binding 1902437:positive regulation of male mating behavior 0043066:negative regulation of apoptotic process 0042220:response to cocaine
PDB	5IX0 ; 6WBZ ; 5IWG ; 7KBG ; 7KBH ; 6G3O ; 6WBW ; 4LXZ ; 3MAX ; 6XEB ; 6XEC ; 6XDM ; 4LY1
Drugbank	DB01303 ; DB05015 ; DB00175 ; DB06176 ; DB00227 ; DB05223 ; DB01223 ; DB00641 ; DB00277 ; DB02546 ; DB01076 ; DB11830 ; DB06603 ; DB00313 ; DB09091 ; DB01095
KEGG	hsa:3066

Type

Detail

Target ID

T68M1D

Protein Name

Histone deacetylase 2

Uniprot ID

Q92769

Protein Name Alias

HD2; EC 3.5.1.98

Gene ID

3066

Gene Symbol

HDAC2

Gene Alias

TTD

T51191: Clinical Trial target

Pfam

PF00850

0008134:transcription factor binding

0005634:nucleus

0061029:eyelid development in camera-type eye

0003300:cardiac muscle hypertrophy

0004407:histone deacetylase activity

0043044:ATP-dependent chromatin remodeling

0070301:cellular response to hydrogen peroxide

0061000:negative regulation of dendritic spine development

0043565:sequence-specific DNA binding

0061198:fungiform papilla formation

0033558:protein deacetylase activity

0000118:histone deacetylase complex

0032732:positive regulation of interleukin-1 production

0016581:NuRD complex

1903351:cellular response to dopamine

0003682:chromatin binding

0001103:RNA polymerase II repressing transcription factor binding

0009913:epidermal cell differentiation

0048714:positive regulation of oligodendrocyte differentiation

0035098:ESC/E(Z) complex

0008284:positive regulation of cell population proliferation

0001975:response to amphetamine

0045347:negative regulation of MHC class II biosynthetic process

0071560:cellular response to transforming growth factor beta stimulus

0042733:embryonic digit morphogenesis

0032041:NAD-dependent histone deacetylase activity (H3-K14 specific)

0045892:negative regulation of transcription, DNA-templated

0005737:cytoplasm

1901796:regulation of signal transduction by p53 class mediator

0051059:NF-kappaB binding

0007596:blood coagulation

0019899:enzyme binding

0032922:circadian regulation of gene expression

0070933:histone H4 deacetylation

0000785:chromatin

1990841:promoter-specific chromatin binding

0043392:negative regulation of DNA binding

0042493:response to drug

0042531:positive regulation of tyrosine phosphorylation of STAT protein

0019213:deacetylase activity

0003723:RNA binding

0070932:histone H3 deacetylation

0042475:odontogenesis of dentin-containing tooth

0032967:positive regulation of collagen biosynthetic process

0035094:response to nicotine

0032991:protein-containing complex

0031000:response to caffeine

0031072:heat shock protein binding

0016575:histone deacetylation

0045862:positive regulation of proteolysis

0010718:positive regulation of epithelial to mesenchymal transition

0045893:positive regulation of transcription, DNA-templated

0071300:cellular response to retinoic acid

0070829:heterochromatin maintenance

0043433:negative regulation of DNA-binding transcription factor activity

0048149:behavioral response to ethanol

0000122:negative regulation of transcription by RNA polymerase II

2000273:positive regulation of signaling receptor activity

0032760:positive regulation of tumor necrosis factor production

0060789:hair follicle placode formation

0010977:negative regulation of neuron projection development

0016358:dendrite development

0032496:response to lipopolysaccharide

0005654:nucleoplasm

0006338:chromatin remodeling

0034605:cellular response to heat

2000757:negative regulation of peptidyl-lysine acetylation

0016580:Sin3 complex

0045944:positive regulation of transcription by RNA polymerase II

0055093:response to hyperoxia

0042826:histone deacetylase binding

1902437:positive regulation of male mating behavior

0043066:negative regulation of apoptotic process

0042220:response to cocaine

PDB

5IX0 ; 6WBZ ; 5IWG ; 7KBG ; 7KBH ; 6G3O ; 6WBW ; 4LXZ ; 3MAX ; 6XEB ; 6XEC ; 6XDM ; 4LY1

Drugbank

DB01303 ; DB05015 ; DB00175 ; DB06176 ; DB00227 ; DB05223 ; DB01223 ; DB00641 ; DB00277 ; DB02546 ; DB01076 ; DB11830 ; DB06603 ; DB00313 ; DB09091 ; DB01095

KEGG

hsa:3066

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Name: Diazepam

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Name: Silibinin

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Name: Valproic Acid

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Name: Apicidin

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Name: Alcohol

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis
H0522	Tai Zi Shen	太子参	Heterophylly falsestarwort root	Radix pseudostellariae
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H0095	Gou Qi Zi	枸杞子	Chinese wolfberry fruit	Lycium chinense
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0794	Zhe Bei Mu	浙贝母	Thunberg fritillary	Fritillaria verticillata var. thunbergii
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0094	Gou Qi	枸杞	Chinese wolfberry fruit	Lycium chinense
H0416	Shan Shen	山参	NA	Panax ginseng
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 16)