Target Description

Type Detail
Target ID T33OSQ
Protein Name Sterol regulatory element-binding protein 1
Uniprot ID P36956
Protein Name Alias SREBP-1;  Class D basic helix-loop-helix protein 1;  bHLHd1;  Sterol regulatory element-binding transcription factor 1
Gene ID 6720
Gene Symbol SREBF1
Gene Alias BHLHD1;  SREBP1
TTD T47236: Research target
Pfam PF00010
GO
0008203:cholesterol metabolic process

0005634:nucleus

0006629:lipid metabolic process

0007623:circadian rhythm

0005829:cytosol

0046983:protein dimerization activity

0051591:response to cAMP

0003700:DNA-binding transcription factor activity

0032991:protein-containing complex

0030324:lung development

0001228:DNA-binding transcription activator activity, RNA polymerase II-specific

0042789:mRNA transcription by RNA polymerase II

1903146:regulation of autophagy of mitochondrion

0031647:regulation of protein stability

0009267:cellular response to starvation

1990837:sequence-specific double-stranded DNA binding

0010867:positive regulation of triglyceride biosynthetic process

0019216:regulation of lipid metabolic process

0019217:regulation of fatty acid metabolic process

0005654:nucleoplasm

0032526:response to retinoic acid

0032933:SREBP signaling pathway

0004879:nuclear receptor activity

0032810:sterol response element binding

0045944:positive regulation of transcription by RNA polymerase II

0010883:regulation of lipid storage

0033762:response to glucagon

0071398:cellular response to fatty acid

0005789:endoplasmic reticulum membrane

0005783:endoplasmic reticulum

0003682:chromatin binding

0012507:ER to Golgi transport vesicle membrane

0044877:protein-containing complex binding

0030522:intracellular receptor signaling pathway

0008610:lipid biosynthetic process

0045542:positive regulation of cholesterol biosynthetic process

0016021:integral component of membrane

0032094:response to food

0000122:negative regulation of transcription by RNA polymerase II

0000139:Golgi membrane

0006357:regulation of transcription by RNA polymerase II

0045444:fat cell differentiation

1903214:regulation of protein targeting to mitochondrion

0032570:response to progesterone

0005635:nuclear envelope

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0000977:RNA polymerase II transcription regulatory region sequence-specific DNA binding

0046676:negative regulation of insulin secretion

1902895:positive regulation of pri-miRNA transcription by RNA polymerase II

0045471:response to ethanol

0010876:lipid localization

0009749:response to glucose

0031065:positive regulation of histone deacetylation

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0003677:DNA binding

0019901:protein kinase binding

0042493:response to drug

0007568:aging

0003062:regulation of heart rate by chemical signal

0005737:cytoplasm

0008286:insulin receptor signaling pathway

0045540:regulation of cholesterol biosynthetic process

0000785:chromatin

PDB 1AM9
Drugbank DB11133 ; DB09539 ; DB13961 ; DB03756
KEGG hsa:6720

Related Compounds  (Total: 18)

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C0213
Name: Metformin
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C0302
Name: Phloretin
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C0337
Name: Puerarin
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C0399
Name: Sesamin
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C0403
Name: Silibinin


Related Herbs  (Total: 215)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0609 Wu Wei Zi Liu Jin Gao五味子流浸膏 Five-flavor berrySchisandra chinensis
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0613 Wu Yue Ai五月艾 ArtemisiaArtemisia princeps
H0605 Wu Wei Zi五味子 Chinese magnoliavineSchisandra chinensis
H0802 Zhi Geng枳梗 NACitrus aurantium
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H1061 Bai He百合 LilyLilium brownii
H0357 Ren Shen人参 GinsengPanax ginseng
H0002 Hui Xiang茴香 Fennel fruitFoeniculum vulgare
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H0790 Zhang Shu Zi樟树子 Camphor treeCinnamomum camphora
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H0390 Sang Ji Sheng桑寄生 Parasite scurrulaLoranthus parasiticus
H0042 Bai Tou Weng白头翁 Chinese pulsatillaPulsatilla chinensis
H0029 Jiang Huang Lian姜黄连 Coptis deltoideaCoptis chinensis
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1181 Hei Zhi Ma黑芝麻 Oriental sesameSesamum indicum
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium
H1086 Bai Hua Cai Zi白花菜子 Common spiderflower seedCleome gynandra
H0142 Liang Jiang良姜 NAAlpinia officinarum
H0585 Tu Yin Chen Hao土茵陈蒿 Capillary wormwoodArtemisia capillaris
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0674 Xin Yi辛夷 Lily magnolia budsMagnolia liliflora
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0659 Chai Hu Jin Gao柴胡浸膏 Chinese thorowaxBupleurum chinense
H0708 Yuan Hua Gen芫花根 Lilac daphne rootDaphne genkwa
H0989 Ding Kui Cao丁葵草 Herb of twinleaf zorniaKummerowia striata
H0967 Di Er Cao地耳草 Japanese stJohn’swortHypericum japonicum
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H1068 Bai He Liu Jin Gao百合流浸膏 LilyLilium brownii
H0607 Wu Wei Zi Jin Chu Wu五味子浸出物 Five-flavor berrySchisandra chinensis
H0644 Xiang Mao香茅 LemongrassCymbopogon citratus
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H1207 Hu Ma胡麻 white seed of oriental sesameSesamum indicum
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H1225 Huai Mi槐米 NASophora japonica
H0318 Pu Tao(1)蒲桃 SyzygiumSyzygium jambos
H0746 Yin Chen Hao Gan Jin Gao茵陈蒿干浸膏 Capillary wormwoodArtemisia capillaris
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H0300 Nv Zhen Zi女贞子 Glossy privet fruitLigustrum lucidum
H0676 Xin Yi Hua Jin Gao Fen辛夷花浸膏粉 MagnoliaMagnolia liliflora
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H1133 Gui Jian Yu鬼箭羽 Winged euonymusEuonymus alatus
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H0418 Shan Yin Chen山茵陈 Capillary wormwoodArtemisia capillaris
H0762 Yu Li Ren郁李仁 NAPrunus japonica
H0855 Chuan Bei Mu川贝母 Fritillaria unibracteataFritillaria cirrhosa
H1227 Huai Zhi槐枝 NASophora japonica
H0719 Chen Pi陈皮 Dried tangerine peelPericarpium citri reticulatae
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0207 Ma Wei Song Shu Gen马尾松树根 NAPinus massoniana
H0120 Ban Bian Qi半边旗 pinnated brake herbPteris semipinnata
H0024 Jia 蒟ye假蒟叶 Sarmentose pepperPiper sarmentosum
H0788 Zhang Nao Zi樟脑子 CamphorarCinnamomum camphora
H0233 Mao Liang Mian Zhen毛两面针 NAZanthoxylum nitidum
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0289 Niu Bang Zi牛蒡子 Great burdock fruitArctium lappa
H0663 Xiao Ji小蓟 Setose thistleCirsium setosum
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0206 Ma Wei Song Gen马尾松根 NAPinus massoniana
H1215 Hua Ju Hong化橘红 Pummelo peelExocarpium citri grandis
H0022 Jia Ju假蒟 Sarmentose pepperPiper sarmentosum
H0522 Tai Zi Shen太子参 Heterophylly falsestarwort rootRadix pseudostellariae
H0229 Mao Da Ding Cao毛大丁草 Pilose gerberaGerbera piloselloides
H0112 Ku Xing Ren苦杏仁 bitter apricot seedSemen armeniacae amarum
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H0574 Cao Dou Kou草豆蔻 Katsumada galangalAlpinia katsumadai
H0711 Yuan Hua Zhi Tiao芫花枝条 stem of lilac daphneDaphne genkwa
H0604 Wu Wei Teng五味藤 NASecuridaca inappendiculata
H0253 Mian Hua Gen棉花根 Levant cotton rootGossypium herbaceum
H0785 Ze Xi Huang Lian择细黄连 Coptis deltoideaCoptis chinensis
H0060 Jin Si Ku Lian金丝苦楝 NACardiospermum halicacabum
H0580 Tu Si Rou菟丝肉 Dodder seedCuscuta australis
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0581 Tu Si Zi菟丝子 Dodder seedCuscuta australis
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H0678 Xin Yi Ren辛夷仁 MagnoliaMagnolia liliflora
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0652 Xiang Yuan Pi香橼皮 Wilson citronCitrus medica
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H0098 Ju Ye San Qi菊叶三七 NAGynura japonica
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H1231 Huang Bai Tan黄柏炭 Amur corktreePhellodendron amurense
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H1060 Fo Shou佛手 Fleshfingered citronCitrus medica var. sarcodactylis
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H0786 Zhang Mu樟木 Ligum cinmamomi camphoraeCinnamomum camphora
H0918 Cu Yuan Hua醋芫花 Lilac daphneDaphne genkwa
H1242 Huang Lian Gan Jin Gao黄连干浸膏 Coptis deltoideaCoptis chinensis
H0665 Chai Hu Shao柴胡梢 Chinese thorowaxBupleurum chinense
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0848 Zi Jin Niu紫金牛 Japanese ardisiaArdisia japonica
H0706 Yan Hu Suo延胡索 YanhusuoCorydalis yanhusuo
H0507 Song Zhi松脂 RosinPinus massoniana
H0094 Gou Qi枸杞 Chinese wolfberry fruitLycium chinense
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H0805 Zhi Ke Gan Jin Gao枳壳干浸膏 Seville ora nge unripe fruitCitrus aurantium
H0583 Tu Si Zi Teng菟丝子藤 Dodder seedCuscuta australis
H0601 Wu Mei乌梅 Japanese apricotPrunus mume
H0020 Ji Yan Cao鸡眼草 Striate kummerowiaKummerowia striata
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H0130 Lei Gong Teng雷公藤 Common threewingnutTripterygium wilfordii
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1214 Hua Jiao花椒 Bunge pricklyashZanthoxylum bungeanum
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H0829 Zhu Jie Xiang Fu竹节香附 rhizome of radde anemoneAnemone raddeana
H0745 Yin Chen Hao茵陈蒿 Capillary wormwoodArtemisia capillaris
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0903 Ci Cai荠菜 ShepherdspurseCapsella bursa-pastoris
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0093 Ju Pi橘皮 Tangerine pericarpCitrus reticulata
H0827 Zhu Hong Jun竹红菌 Bambusa hypocrella*Hypocrella bambusae
H0760 Yu Huang Lian萸黄连 Coptis deltoideaCoptis chinensis
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0682 Xiong Huang Lian雄黄连 Coptis deltoideaCoptis chinensis
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0361 Ren Zi Cao人字草 Herb of twinleaf zorniaKummerowia striata
H0410 Shan Jiang Zi山姜子 NALitsea cubeba
H1217 Bai Mei Hua白梅花 Japanese apricot flowerPrunus mume
H0859 Chuan Bei Mu Liu Jin Gao川贝母流浸膏 Fritillaria unibracteataFritillaria cirrhosa
H0872 Chuan Huang Lian川黄连 rhizome of chinese goldthreadCoptis chinensis
H0095 Gou Qi Zi枸杞子 Chinese wolfberry fruitLycium chinense
H1243 Huang Lian Xu黄连须 Coptis deltoideaCoptis chinensis
H0710 Yuan Hua Tiao芫花条 stem of lilac daphneDaphne genkwa
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H1232 Huang Cao Wu黄草乌 NAAconitum vilmorinianum
H1165 He Shi鹤虱 Common carpesium fruitFructus carpesii
H0595 Wu Hua Guo无花果 FigFicus carica
H0297 Niu Xi牛膝 Twotooth achyranthesAchyranthes bidentata
H0714 Yan Tai Chai Hu烟台柴胡 Chinese thorowaxBupleurum chinense
H1241 Huang Lian黄连 Coptis deltoideaCoptis chinensis
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H0801 Chong Bai La虫白蜡 Cera chinensis waxEricerus pela
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0082 Jiu Huang Lian酒黄连 Coptis deltoideaCoptis chinensis
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H0707 Yuan Hua芫花 Lilac daphneDaphne genkwa
H0675 Xin Yi Hua辛夷花 MagnoliaMagnolia liliflora
H1178 Hei Jiang黑姜 Prepared gingerRhizoma zingiberis recens preparata
H0306 Pei Lan佩兰 FortuneEupatorium fortunei
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1115 Guan Huang Bai关黄柏 Amur cork treePhellodendron amurense
H0606 Wu Wei Zi Chun Jin Gao五味子醇浸膏 Five-flavor berrySchisandra chinensis
H0006 Bai Qu Cai白屈菜 Greater celandineChelidonium majus
H1005 Dou Chi Jiang豆豉姜 Folium litseae cubebaeLitsea cubeba
H1230 Huang Bai Fen黄柏粉 Amur corktreePhellodendron amurense
H0030 Jiang Pi姜皮 Ginger peelCortex zingiberis
H0685 Xuan Cao Gen萱草根 Orange daylilyHemerocallis fulva
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0373 Bian Luo Bo卞萝卜 carrotDaucus carota var. sativa
H0088 Ju He橘核 Tangerine seedCitrus reticulata
H0938 Da Suan大蒜 GarlicAllium sativum
H0096 Ju San Qi菊三七 NAGynura japonica
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H1004 Bai Cha白茶 White teaCamellia sinensis
H0608 Wu Wei Zi Jin Gao五味子浸膏 Five-flavor berrySchisandra chinensis
H0651 Xiang Yuan香橼 Wilson citronCitrus medica
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0629 Xi Xin细辛 Siebold wildgingerAsarum sieboldii
H0704 Yan Guan Huang Bai盐关黄柏 Amur cork treePhellodendron amurense
H0705 Yan Hu Lu Ba盐胡芦巴 FenugreekTrigonella foenum-graecum
H0764 Yu Xing Cao鱼腥草 Heartleaf houttuyniaHouttuynia cordata
H1211 Bai Mei白眉 pilose gerbera herbGerbera piloselloides
H0139 Lian Qiao连翘 Weeping forsythiaForsythia suspensa
H0403 Shan Cang Zi山苍子 NALitsea cubeba
H0296 Niu Teng牛藤 twotooth achyranthes rootAchyranthes bidentata
H0295 Bi Ba荜茇 Long pepperPiper longum
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0650 Chai Hu柴胡 Chinese thorowaxBupleurum chinense
H0506 Song Xiang松香 ColophonyPinus massoniana
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0602 Wu Mei Rou乌梅肉 EbonyPrunus mume
H1228 Huang Bai黄柏 Amur corktreePhellodendron amurense
H1208 Hu Ma Ren胡麻仁 white seed of oriental sesameSesamum indicum
H0158 Liu Ling Ju六棱菊 NALaggera alata
H0582 Cao Dou Kou Ren草豆蔻仁 Katsumada galangalAlpinia katsumadai
H0527 Tao PeachPrunus persica
H0787 Zhang Nao樟脑 CamphorarCinnamomum camphora
H0789 Zhang Shu Gen樟树根 Camphor treeCinnamomum camphora
H0679 Xing Ren杏仁 Apricot seedPrunus armeniaca
H1037 Fen Ge粉葛 Thomson kudzuvinePueraria thomsonii
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0303 Bi Cheng Qie毕澄茄 Cubeba pepperPiper cubeba
H0416 Shan Shen山参 NAPanax ginseng
H0633 Xia Tian Wu夏天无 Decumbent corydalisCorydalis decumbens
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis