Compound Description

ID:   C0192 Common name:   Lipoic Acid
IUPAC:  5-[(3R)-dithiolan-3-yl]pentanoic acid CAS:  CAS:1200-22-2
Chembl ID:   CHEMBL134342 Pubchem ID:   CID:6112
Formula:  C8H14O2S2 TCM-ID:  TCMC1499
Smiles:  C1CSSC1CCCCC(=O)O
Alias:

1,2-Dithiolane-3-pentanoic acid, (R)-;

1,2-Dithiolane-3-valeric acid, (+)-;

(3R)-1,2-Dithiolane-3-pentanoic acid;

(R)-(+)-1,2-Dithiolane-3-pentanoic acid;

(R)-(+)-α-Lipoic acid;

(R)-5-(1,2-Dithiolan-3-yl)pentanoicacid;

(R)-Lipoic acid;

(R)-α-Lipoic acid;

Berlition;

Byodinoral 300;

Destior-R;

Lipoec;

Lipoic acid;

Matris thioctic;

R-(+)-Thioctic acid;

Thioderm;

Thiogamma;

Tiobec;

Tiobec Retard;

alpha-Lipoic acid;

d-Thioctic acid;

α-(+)-Lipoic acid;

α-Lipoic acid
Structure:

Related Targets  (Total: 28)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T32OC4 Aldehyde dehydrogenase, mitochondrialALDH2 P05091
A 2 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
A 1 Reference(s)
T16BEL [Pyruvate dehydrogenasePDK4 Q16654
A 1 Reference(s)
T58XLK Tyrosine-protein phosphatase non-receptor type 1PTPN1 P18031
B 1 Reference(s)
T16A2X CatalaseCAT P04040
B 1 Reference(s)
T06QUL FractalkineCX3CL1 P78423
B 1 Reference(s)
T58K62 Frataxin, mitochondrialFXN Q16595
B 1 Reference(s)
T13KGH TyrosinaseTYR P14679
B 1 Reference(s)
T23P74 Caspase-9CASP9 P55211
B 1 Reference(s)
T88KAD Sphingomyelin phosphodiesterase 2SMPD2 O60906
B 1 Reference(s)
T93WZG G1/S-specific cyclin-D1CCND1 P24385
B 1 Reference(s)
T86ROZ Heme oxygenase 1HMOX1 P09601
B 2 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
B 1 Reference(s)
T83YZD AcetylcholinesteraseACHE P22303
B 1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
B 2 Reference(s)
T89L4V InsulinINS P01308
B 1 Reference(s)
T09AAD NADPH--cytochrome P450 reductasePOR P16435
B 1 Reference(s)
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
B 1 Reference(s)
T83QQX Cytochrome b-245 light chainCYBA P13498
B 1 Reference(s)
T00H7Q Neutrophil cytosol factor 1NCF1 P14598
B 1 Reference(s)
T33OPP Interleukin-6IL6 P05231
B 1 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
B 1 Reference(s)
T59IKQ Vascular cell adhesion protein 1VCAM1 P19320
B 1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
C 1 Reference(s)
T43SM9 Peroxisome proliferator-activated receptor gamma coactivator 1-alphaPPARGC1A Q9UBK2
C 1 Reference(s)
T70SFS Superoxide dismutase [Mn], mitochondrialSOD2 P04179
C 1 Reference(s)
T90XYZ C-reactive proteinCRP P02741
C 2 Reference(s)
T10RDU Patatin-like phospholipase domain-containing protein 2PNPLA2 Q96AD5
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 2)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens