Target Description

Type Detail
Target ID T58K62
Protein Name Frataxin, mitochondrial
Uniprot ID Q16595
Protein Name Alias EC 1.16.3.1;  Friedreich ataxia protein;  Fxn
Gene ID 2395
Gene Symbol FXN
Gene Alias FRDA;  X25
TTD NA
Pfam PF01491
GO
0016226:iron-sulfur cluster assembly

0010722:regulation of ferrochelatase activity

0051537:2 iron, 2 sulfur cluster binding

0016540:protein autoprocessing

0034986:iron chaperone activity

0006783:heme biosynthetic process

0051349:positive regulation of lyase activity

0008198:ferrous iron binding

0070301:cellular response to hydrogen peroxide

0043066:negative regulation of apoptotic process

1904231:positive regulation of succinate dehydrogenase activity

0019230:proprioception

0004322:ferroxidase activity

1904234:positive regulation of aconitate hydratase activity

0006119:oxidative phosphorylation

0040015:negative regulation of multicellular organism growth

0007005:mitochondrion organization

0005829:cytosol

0030307:positive regulation of cell growth

0006811:ion transport

0007628:adult walking behavior

0009060:aerobic respiration

0018283:iron incorporation into metallo-sulfur cluster

0046621:negative regulation of organ growth

0008199:ferric iron binding

0090201:negative regulation of release of cytochrome c from mitochondria

0005739:mitochondrion

0009792:embryo development ending in birth or egg hatching

0008284:positive regulation of cell population proliferation

0005759:mitochondrial matrix

1990221:L-cysteine desulfurase complex

0006879:cellular iron ion homeostasis

0010039:response to iron ion

0043085:positive regulation of catalytic activity

PDB 1LY7 ; 3T3K ; 3T3T ; 1EKG ; 6NZU ; 3S5E ; 3S5F ; 3T3J ; 5KZ5 ; 3S4M ; 3S5D ; 3T3L ; 3T3X
Drugbank DB01592 ; DB14489 ; DB14491 ; DB14488 ; DB14501 ; DB14490
KEGG hsa:2395

Related Compounds  (Total: 3)

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C0024
Name: Dimethylformamide
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C0192
Name: Lipoic Acid
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C0363
Name: Resveratrol


Related Herbs  (Total: 27)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0357 Ren Shen人参 GinsengPanax ginseng
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0416 Shan Shen山参 NAPanax ginseng
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena