Target Description

Type Detail
Target ID T06QUL
Protein Name Fractalkine
Uniprot ID P78423
Protein Name Alias C-X3-C motif chemokine 1;  CX3C membrane-anchored chemokine;  Neurotactin;  Small-inducible cytokine D1
Gene ID 6376
Gene Symbol CX3CL1
Gene Alias FKN;  NTT;  SCYD1
TTD T34405: Research target
Pfam PF00048
GO
0005178:integrin binding

0002548:monocyte chemotaxis

0032720:negative regulation of tumor necrosis factor production

2001234:negative regulation of apoptotic signaling pathway

0016021:integral component of membrane

0009986:cell surface

0007186:G protein-coupled receptor signaling pathway

0030336:negative regulation of cell migration

0010812:negative regulation of cell-substrate adhesion

0005102:signaling receptor binding

0071346:cellular response to interferon-gamma

0110091:negative regulation of hippocampal neuron apoptotic process

0005576:extracellular region

0001954:positive regulation of cell-matrix adhesion

0019221:cytokine-mediated signaling pathway

0006952:defense response

0006935:chemotaxis

0045237:CXCR1 chemokine receptor binding

0030593:neutrophil chemotaxis

0031664:regulation of lipopolysaccharide-mediated signaling pathway

0032690:negative regulation of interleukin-1 alpha production

0042056:chemoattractant activity

0070098:chemokine-mediated signaling pathway

0016322:neuron remodeling

0043410:positive regulation of MAPK cascade

1900450:negative regulation of glutamate receptor signaling pathway

0043066:negative regulation of apoptotic process

0043025:neuronal cell body

0098883:synapse pruning

0001774:microglial cell activation

0043547:positive regulation of GTPase activity

0050902:leukocyte adhesive activation

0002523:leukocyte migration involved in inflammatory response

0031737:CX3C chemokine receptor binding

0050767:regulation of neurogenesis

0002931:response to ischemia

0051281:positive regulation of release of sequestered calcium ion into cytosol

0048471:perinuclear region of cytoplasm

0048167:regulation of synaptic plasticity

0048245:eosinophil chemotaxis

0050729:positive regulation of inflammatory response

0008284:positive regulation of cell population proliferation

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0007155:cell adhesion

0051092:positive regulation of NF-kappaB transcription factor activity

0051897:positive regulation of protein kinase B signaling

0033622:integrin activation

0016020:membrane

0032715:negative regulation of interleukin-6 production

0060326:cell chemotaxis

2001223:negative regulation of neuron migration

0048247:lymphocyte chemotaxis

0030595:leukocyte chemotaxis

1904141:positive regulation of microglial cell migration

0005886:plasma membrane

0002052:positive regulation of neuroblast proliferation

0050918:positive chemotaxis

0048661:positive regulation of smooth muscle cell proliferation

0045944:positive regulation of transcription by RNA polymerase II

0006955:immune response

1903721:positive regulation of I-kappaB phosphorylation

1903979:negative regulation of microglial cell activation

0010976:positive regulation of neuron projection development

0071356:cellular response to tumor necrosis factor

0006954:inflammatory response

0048020:CCR chemokine receptor binding

0007568:aging

0061518:microglial cell proliferation

0005615:extracellular space

0035425:autocrine signaling

0070050:neuron cellular homeostasis

0051041:positive regulation of calcium-independent cell-cell adhesion

0007267:cell-cell signaling

0008009:chemokine activity

0071347:cellular response to interleukin-1

0042995:cell projection

0098609:cell-cell adhesion

0070374:positive regulation of ERK1 and ERK2 cascade

0032233:positive regulation of actin filament bundle assembly

0032691:negative regulation of interleukin-1 beta production

PDB 4XT1 ; 1B2T ; 5WB2 ; 4XT3 ; 1F2L ; 3ONA
Drugbank NA
KEGG hsa:6376

Related Compounds  (Total: 3)

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C0192
Name: Lipoic Acid
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C0363
Name: Resveratrol
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C0934
Name: Aspirin


Related Herbs  (Total: 32)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0357 Ren Shen人参 GinsengPanax ginseng
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0416 Shan Shen山参 NAPanax ginseng
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin