HIT-result

Type	Detail
Target ID	T71PTC
Protein Name	Protein kinase C iota type
Uniprot ID	P41743
Protein Name Alias	EC 2.7.11.13; Atypical protein kinase C-lambda/iota; PRKC-lambda/iota; aPKC-lambda/iota; nPKC-iota
Gene ID	5584
Gene Symbol	PRKCI
Gene Alias	DXS1179E
TTD	T83174: Research target
Pfam	PF00564 ; PF00069 ; PF00130 ; PF00433
GO	0005634:nucleus 0045747:positive regulation of Notch signaling pathway 0070062:extracellular exosome 0035556:intracellular signal transduction 0004672:protein kinase activity 0004698:calcium-dependent protein kinase C activity 0106310:protein serine kinase activity 0043524:negative regulation of neuron apoptotic process 0010976:positive regulation of neuron projection development 0005829:cytosol 0004674:protein serine/threonine kinase activity 0015630:microtubule cytoskeleton 0048194:Golgi vesicle budding 0106311:protein threonine kinase activity 0016324:apical plasma membrane 0098978:glutamatergic synapse 0045216:cell-cell junction organization 0035089:establishment of apical/basal cell polarity 0070830:bicellular tight junction assembly 2000353:positive regulation of endothelial cell apoptotic process 0045171:intercellular bridge 0061024:membrane organization 0018105:peptidyl-serine phosphorylation 0051092:positive regulation of NF-kappaB transcription factor activity 0000139:Golgi membrane 0043220:Schmidt-Lanterman incisure 0005543:phospholipid binding 0099072:regulation of postsynaptic membrane neurotransmitter receptor levels 0070555:response to interleukin-1 0006612:protein targeting to membrane 0005524:ATP binding 0005886:plasma membrane 0034351:negative regulation of glial cell apoptotic process 0098685:Schaffer collateral - CA1 synapse 0004697:protein kinase C activity 0031252:cell leading edge 0060252:positive regulation of glial cell proliferation 0043066:negative regulation of apoptotic process 0016192:vesicle-mediated transport 1903078:positive regulation of protein localization to plasma membrane 0006468:protein phosphorylation 0032869:cellular response to insulin stimulus 0042462:eye photoreceptor cell development 0005923:bicellular tight junction 0046326:positive regulation of glucose import 0016477:cell migration 0005654:nucleoplasm 0046872:metal ion binding 0045197:establishment or maintenance of epithelial cell apical/basal polarity 0007010:cytoskeleton organization 0007015:actin filament organization 0005768:endosome 0046903:secretion
PDB	5LI9 ; 1VD2 ; 1WMH ; 5LI1 ; 6ILZ ; 3ZH8 ; 1ZRZ ; 5LIH ; 3A8W ; 3A8X
Drugbank	DB12010 ; DB03777 ; DB00675
KEGG	hsa:5584

Go to browser

Name: Metformin

Go to browser

Name: Aicar

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens