Target Description

Type Detail
Target ID T11FH6
Protein Name Phosphatidylinositol 3-kinase regulatory subunit alpha
Uniprot ID P27986
Protein Name Alias PI3-kinase regulatory subunit alpha;  PI3K regulatory subunit alpha;  PtdIns-3-kinase regulatory subunit alpha;  Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha;  PI3-kinase subunit p85-alpha;  PtdIns-3-kinase regulatory subunit p85-alpha
Gene ID 5295
Gene Symbol PIK3R1
Gene Alias GRB1
TTD NA
Pfam PF00017 ; PF16454 ; PF00620
GO
0043559:insulin binding

0005801:cis-Golgi network

0019903:protein phosphatase binding

0008134:transcription factor binding

0006606:protein import into nucleus

0007186:G protein-coupled receptor signaling pathway

0005068:transmembrane receptor protein tyrosine kinase adaptor activity

0060396:growth hormone receptor signaling pathway

0048009:insulin-like growth factor receptor signaling pathway

0051497:negative regulation of stress fiber assembly

0038128:ERBB2 signaling pathway

0043548:phosphatidylinositol 3-kinase binding

0001784:phosphotyrosine residue binding

0008625:extrinsic apoptotic signaling pathway via death domain receptors

0042307:positive regulation of protein import into nucleus

0019221:cytokine-mediated signaling pathway

1903078:positive regulation of protein localization to plasma membrane

0043125:ErbB-3 class receptor binding

0043066:negative regulation of apoptotic process

0032760:positive regulation of tumor necrosis factor production

1900103:positive regulation of endoplasmic reticulum unfolded protein response

0007173:epidermal growth factor receptor signaling pathway

0010592:positive regulation of lamellipodium assembly

0034644:cellular response to UV

0038095:Fc-epsilon receptor signaling pathway

0036312:phosphatidylinositol 3-kinase regulatory subunit binding

0120183:positive regulation of focal adhesion disassembly

0050821:protein stabilization

0005911:cell-cell junction

0048471:perinuclear region of cytoplasm

0046935:1-phosphatidylinositol-3-kinase regulator activity

0014065:phosphatidylinositol 3-kinase signaling

0005943:phosphatidylinositol 3-kinase complex, class IA

0001953:negative regulation of cell-matrix adhesion

0005159:insulin-like growth factor receptor binding

0043551:regulation of phosphatidylinositol 3-kinase activity

0050852:T cell receptor signaling pathway

0034976:response to endoplasmic reticulum stress

0051897:positive regulation of protein kinase B signaling

0006661:phosphatidylinositol biosynthetic process

0008286:insulin receptor signaling pathway

0051491:positive regulation of filopodium assembly

0000165:MAPK cascade

0016020:membrane

0033120:positive regulation of RNA splicing

0008630:intrinsic apoptotic signaling pathway in response to DNA damage

0048010:vascular endothelial growth factor receptor signaling pathway

0005886:plasma membrane

0046854:phosphatidylinositol phosphorylation

0045944:positive regulation of transcription by RNA polymerase II

0005634:nucleus

0046326:positive regulation of glucose import

0007411:axon guidance

1990578:perinuclear endoplasmic reticulum membrane

0005158:insulin receptor binding

0030183:B cell differentiation

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0034446:substrate adhesion-dependent cell spreading

0030168:platelet activation

0038096:Fc-gamma receptor signaling pathway involved in phagocytosis

0045671:negative regulation of osteoclast differentiation

0006468:protein phosphorylation

0050900:leukocyte migration

0031295:T cell costimulation

0005829:cytosol

0046982:protein heterodimerization activity

0046626:regulation of insulin receptor signaling pathway

0005942:phosphatidylinositol 3-kinase complex

0043560:insulin receptor substrate binding

0005737:cytoplasm

0030335:positive regulation of cell migration

0032869:cellular response to insulin stimulus

0048015:phosphatidylinositol-mediated signaling

0005168:neurotrophin TRKA receptor binding

0001678:cellular glucose homeostasis

0016032:viral process

0035014:phosphatidylinositol 3-kinase regulator activity

PDB 4WAF ; 4L2Y ; 4OVU ; 4ZOP ; 5ITD ; 4OVV ; 5SXC ; 5XGI ; 3HIZ ; 1AZG ; 5SX9 ; 5SXA ; 2V1Y ; 5SXK ; 4L23 ; 1A0N ; 5SXI ; 5XGJ ; 5VLR ; 4A55 ; 6NCT ; 7CIO ; 5UKJ ; 5SXB ; 6PYU ; 5SW8 ; 5SXD ; 1PKT ; 5SWT ; 4YKN ; 6PYR ; 5FI4 ; 5SXE ; 5M6U ; 5GJI ; 1PIC ; 5SWG ; 4JPS ; 2IUI ; 5SX8 ; 2IUH ; 5UBT ; 5SXF ; 5SWR ; 5UK8 ; 5XGH ; 4L1B ; 3I5R ; 5AUL ; 1PBW ; 1H9O ; 5SXJ ; 1PKS ; 5SWO ; 1PHT ; 5UL1 ; 3I5S ; 5SWP ; 2RD0 ; 2IUG ; 3HHM
Drugbank DB05210 ; DB01064 ; DB06486 ; DB08059
KEGG hsa:5295

Related Compounds  (Total: 3)

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C0137
Name: Icaritin
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C0865
Name: Aicar
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C0867
Name: Alcohol


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