Compound Description

ID:   C0456 Common name:   Tretinoin
IUPAC:  (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid CAS:  CAS:302-79-4
Chembl ID:   CHEMBL38 Pubchem ID:   CID:444795
Formula:  C20H28O2 TCM-ID:  TCMC2184
Smiles:  C/C(=C\C=C\C(=C\C(=O)O)\C)/C=C/C1=C(C)CCCC1(C)C
Alias:

Retinoic acid, all-trans-;

(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid;

2,4,6,8-Nonatetraenoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-;

3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid;

AGN 100335;

ATRA;

Aberel;

Airol;

Aknoten;

Atragen;

Cordes Vas;

Dermairol;

Epi-Aberel;

Eudyna;

NSC 122578;

NSC 122758;

Renova;

Retacnyl;

Retin A;

Ro 1-5488;

Tretin M;

Tretinoin;

Vesanoid;

Vesnaroid;

Vitamin A acid;

Vitamin A acid, all-trans-;

Vitamin A1 acid, all-trans-;

all-(E)-Retinoic acid;

all-trans-Retinoic acid;

all-trans-Tretinoin;

all-trans-Vitamin A acid;

all-trans-β-Retinoic acid;

trans-Retinoic acid;

β-Retinoic acid
Structure:

Related Targets  (Total: 75)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T20OEM Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1PIN1 Q13526
A 2 Reference(s)
T62USB Tumor necrosis factor receptor superfamily member 10ATNFRSF10A O00220
A 2 Reference(s)
T77UWH CCAAT/enhancer-binding protein betaCEBPB P17676
A 1 Reference(s)
T45JE9 Alpha-fetoproteinAFP P02771
A 2 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
A 1 Reference(s)
T11ZYR Cytochrome P450 2D6CYP2D6 P10635
A 1 Reference(s)
T82D5L Fibroblast growth factor 21FGF21 Q9NSA1
A 1 Reference(s)
T36P6G Deoxycytidine kinaseDCK P27707
A 1 Reference(s)
T84D97 Growth/differentiation factor 2GDF2 Q9UK05
A 2 Reference(s)
T53S43 Homeobox protein CDX-2CDX2 Q99626
A 1 Reference(s)
T70YKV Baculoviral IAP repeat-containing protein 3BIRC3 Q13489
A 1 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
A 1 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
A 1 Reference(s)
T27U96 Granulocyte-macrophage colony-stimulating factorCSF2 P04141
A 1 Reference(s)
T20PL2 Neutrophil cytosol factor 2NCF2 P19878
A 1 Reference(s)
T33VZN Retinoic acid receptor betaRARB P10826
A 3 Reference(s)
T05SMP Folate receptor betaFOLR2 P14207
A 1 Reference(s)
T46E53 Retinoic acid receptor alphaRARA P10276
A 5 Reference(s)
T29B10 Interleukin-17AIL17A Q16552
A 2 Reference(s)
T93WZG G1/S-specific cyclin-D1CCND1 P24385
A 2 Reference(s)
T09S1E Tumor necrosis factor alpha-induced protein 3TNFAIP3 P21580
A 1 Reference(s)
T53BUI Pro-interleukin-16 [Cleaved into: Interleukin-16IL16 Q14005
A 1 Reference(s)
T38T1U Caspase-8CASP8 Q14790
A 1 Reference(s)
T10S5F Cyclin-dependent kinase 4CDK4 P11802
A 2 Reference(s)
T97FEF Broad substrate specificity ATP-binding cassette transporter ABCG2ABCG2 Q9UNQ0
B 1 Reference(s)
T80LLJ ProhibitinPHB P35232
B 1 Reference(s)
T78ZF2 Protein kinase C alpha typePRKCA P17252
C 1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
C 1 Reference(s)
T26EZU Myc proto-oncogene proteinMYC P01106
C 1 Reference(s)
T11HTL ApelinAPLN Q9ULZ1
C 1 Reference(s)
T26CFB DNA damage-inducible transcript 3 proteinDDIT3 P35638;P0DPQ6
C 1 Reference(s)
T19VO1 Peroxiredoxin-6PRDX6 P30041
C 1 Reference(s)
T13DHC Disintegrin and metalloproteinase domain-containing protein 10ADAM10 O14672
C 1 Reference(s)
T30L86 Tumor necrosis factor receptor superfamily member 10BTNFRSF10B O14763
C 1 Reference(s)
T51U51 Neurogenic locus notch homolog protein 2NOTCH2 Q04721
C 1 Reference(s)
T49CBW Class E basic helix-loop-helix protein 40BHLHE40 O14503
C 1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
C 2 Reference(s)
T13R1V Antigen-presenting glycoprotein CD1dCD1D P15813
C 1 Reference(s)
T65T2J Iron-responsive element-binding protein 2IREB2 P48200
C 1 Reference(s)
T03BE3 Chloride anion exchangerSLC26A3 P40879
C 2 Reference(s)
T29H73 Collagen alpha-1(IX) chainCOL9A1 P20849
C 1 Reference(s)
T32IXS Integrin alpha-MITGAM P11215
C 1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
C 1 Reference(s)
T80D9C Retinoic acid receptor gammaRARG P13631
C 1 Reference(s)
T40JZG GPI-anchor transamidasePIGK Q92643
C 1 Reference(s)
T67X1L Eukaryotic translation initiation factor 2 subunit 1EIF2S1 P05198
C 1 Reference(s)
T47HTN Prostaglandin E synthasePTGES O14684
C 1 Reference(s)
T49XW3 Protein S100-A10S100A10 P60903
C 1 Reference(s)
T22QHE Fibronectin type III domain-containing protein 5FNDC5 Q8NAU1
C 1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
C 1 Reference(s)
T09KQF Proliferating cell nuclear antigenPCNA P12004
C 1 Reference(s)
T94WJB Endothelial transcription factor GATA-2GATA2 P23769
C 1 Reference(s)
T19Q7Y Polycomb group RING finger protein 1PCGF1 Q9BSM1
C 1 Reference(s)
T55H1Y Cytochrome P450 26A1CYP26A1 O43174
C 1 Reference(s)
T41AH6 Proto-oncogene vavVAV1 P15498
C 1 Reference(s)
T73V21 Transcription factor SOX-2SOX2 P48431
C 2 Reference(s)
T97ESI Apolipoprotein EAPOE P02649
C 1 Reference(s)
T10CQU NEDD8-activating enzyme E1 regulatory subunitNAE1 Q13564
C 1 Reference(s)
T98RXH Focal adhesion kinase 1PTK2 Q05397
C 1 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
C 1 Reference(s)
T92LK2 Tumor necrosis factor ligand superfamily member 10TNFSF10 P50591
C 1 Reference(s)
T50V79 Interleukin-4IL4 P05112
C 1 Reference(s)
T99ARN Forkhead box protein P3FOXP3 Q9BZS1
C 1 Reference(s)
T02SEH Homeobox protein Hox-B13HOXB13 Q92826
C 1 Reference(s)
T39JB4 Annexin A1ANXA1 P04083
C 1 Reference(s)
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
C 1 Reference(s)
T54G8J Protein kinase C delta typePRKCD Q05655
C 1 Reference(s)
T15JRW Interferon alpha-inducible protein 27, mitochondrialIFI27 P40305
C 1 Reference(s)
T06JXV CD44 antigenCD44 P16070
C 1 Reference(s)
T40Q1D Retinal dehydrogenase 1ALDH1A1 P00352
C 1 Reference(s)
T33OPP Interleukin-6IL6 P05231
C 1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
C 1 Reference(s)
T37VLU Interferon gammaIFNG P01579
C 1 Reference(s)
T57R3V Proliferation marker protein Ki-67MKI67 P46013
C 1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 2)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens